Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sally A. McCreedy"'
Autor:
Sally A. McCreedy, Kris E. Kucera, David J. Triggle, Matthew Marler, Roberta Mihut, E. S. C. Wu, Jack Gordon, Mary L. Stagnitto, Dan Widzowski, Andrew Howell, Anthony C. Machulskis, John Zongrone, Paul Bialobok, George B. Mullen, Marilyn K. Knowles, Shawn Sitar, James C. Blosser
Publikováno v:
Drug Development Research. 40:117-132
The purpose of these studies was to determine the levels of intrinsic activity in vitro at muscarinic receptor pharmacological subtypes (M1, M2, and M3) that would optimize cognitive activity while minimizing acute adverse cholinergic effects in vivo
Autor:
Alexander Rochester New York Us Kover, James T. Loch, L.Paul Rosenberg, Simon F. Semus, John Zongrone, Anthony C. Machulskis, James C. Blosser, John C. Gordon, Patrick R. Verhoest, Sally A. McCreedy, Edwin S. C. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2525-2530
To improve receptor binding affinity and to investigate functional selectivity of 2,8-dimethyl-1-oxa-8-azaspiro[4.5]decan-3-one acetylhydrazone 2 at muscarinic receptor subtypes, a series of acylhydrazones A was synthesized. The SAR indicates that th
Autor:
Alex Kover, Robert J. Murray, James C. Blosser, R. A. Mack, George B. Mullen, Sally A. McCreedy, James T. Loch, Anthony C. Machulskis, E. S. C. Wu, John C. Gordon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1813-1818
A short and efficient synthesis of both enantiomers of 2,8-dimethyl-1-oxa-8-azaspiro[4.5]-decan-3-one is described. The biological activity of the racemate resides predominantly in the S-enantiomer. While the S-isomer is a full M2-agonist, the R-isom
Autor:
James T. Loch, Robert J. Murray, James C. Blosser, Sally A. McCreedy, E. S. C. Wu, R. A. Mack, Anthony C. Machulskis, George B. Mullen, John C. Gordon, Alexander Rochester New York Us Kover
Publikováno v:
ChemInform. 26
Autor:
Louis R. Freedman, H. Steve White, Ranjit Ray, James C. Blosser, Sally A. McCreedy, Gene C. Palmer, George E. Garske, Ronald C. Griffith, Jose H. Woodhead, Eric W. Harris, Ewart A. Swinyard, Napier James J
Publikováno v:
Epilepsy Research. 9:161-174
Studies conducted by Fisons Pharmaceuticals and the Antiepileptic Drug Development Program (ADD Program) of the Epilepsy Branch (NINDS, NIH) revealed that ‘remacemide’ (FPL 12924, formerly PR 934-423) was effective orally in the prevention of max
Autor:
Ronald C. Griffith, Robert J. Murray, George B. Mullen, Anthony C. Machulskis, Sally A. McCreedy, James C. Blosser, Edwin S. C. Wu, James T. Loch, Alex Kover
Publikováno v:
Journal of medicinal chemistry. 38(9)
The cholinergic hypothesis of Alzheimer's disease suggests that cholinergic agonists may have therapeutic potential for treating the attendant memory deficits of the disease. As part of a program aimed at preparing metabolically stable, nonquaternary
Autor:
Roger L. Papke, J. Blosser, Lynn Wecker, Scott C. Harvey, Anthony C. Machulskis, Michael W. Quick, Elena Battaglioli, Z. I. Yu, Norman Davidson, T. L. Lentz, Henry A. Lester, Ana Belén Elgoyhen, D. C. Chiara, Antonio Figl, M. Hartley, James Richard Boulter, Charles W. Luetje, Floyd N. Maddox, Jishnu Mukerji, Éric Dumont, D. G. Morgan, David S. Johnson, Cesar Labarca, Steve Heinemann, Sally A. McCreedy, Diego Fornasari, Edwin M. Meyer, Francesco Clementi, J. Gordon, C M de Fiebre, Bruce N. Cohen, Roberta Allen, Stephen F. Heinemann, Philippe Séguéla, Jonathan B. Cohen, P. Vetter, Yu Xie
Publikováno v:
Experientia Supplementum ISBN: 9783764350871
Molecular cloning studies have demonstrated structural and functional diversity in neuronal nicotinic acetylcholine receptors. To date, seven a subunits (a2 to a8) and three α subunits (α2 to α4) have been characterised in the nervous system of ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e469eacc881a921fc4eaeea39a49627
https://doi.org/10.1007/978-3-0348-7416-8_8
https://doi.org/10.1007/978-3-0348-7416-8_8
Publikováno v:
Regulatory Mechanisms of Neuron to Vessel Communication in the Brain ISBN: 9783642741548
The central microvasculature consisting of capillaries and pia arachnoid is innervated by adrenergic and peptide neurons acting to regulate local blood flow, promote transport of substances into the brain, control permeability of small molecules and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb525816e6e6360f1aaf55b115ce786
https://doi.org/10.1007/978-3-642-74152-4_7
https://doi.org/10.1007/978-3-642-74152-4_7
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 18(3)
1. Chlorpromazine (CPZ) is a unique molecule which has many potential sites of action, as well as a propensity to be transformed into a host of metabolites possessing varying degrees of pharmacological and/or toxic reactions. This investigation exami