PrPres in placental tissue following experimental transmission of atypical scrapie in ARR/ARR sheep is not infectious by Tg338 mouse bioassay

Autor: Robert B. Piel, Valerie R. McElliott, James B. Stanton, Dongyue Zhuang, Sally A. Madsen-Bouterse, Linda K. Hamburg, Robert D. Harrington, David A. Schneider

Publikováno v: PLoS ONE, Vol 17, Iss 1 (2022)

Nor98-like atypical scrapie is a sporadic disease that affects the central nervous system of sheep and goats that, in contrast to classical scrapie, is not generally regarded as naturally transmissible. However, infectivity has been demonstrated via

Externí odkaz: https://doaj.org/article/19f61a61cac545cdaf83eb446475511c

Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC

Autor: Paula Stewart, Sally A. Madsen-Bouterse, Helen Williamson, David A. Schneider, Wilfred Goldmann

Publikováno v: Genetics, Selection, Evolution : GSE
Genetics Selection Evolution, Vol 53, Iss 1, Pp 1-8 (2021)
Madsen-Bouterse, S A, Stewart, P, Williamson, H, Schneider, D A & Goldmann, W 2021, ' Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC ', Genetics Selection Evolution, vol. 53, no. 1, 52 . https://doi.org/10.1186/s12711-021-00646-x

Expression of the cellular prion protein (PrPC) is crucial for the development of prion diseases. Amino acid changes in PrPC or a reduced amount of PrPC may modulate disease resistance. The relative abundance of C1, a natural α-cleavage fragment of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2584fdae96e9fb8bf02020d6ae4d64b7
https://doi.org/10.1186/s12711-021-00646-x

Pathogen-mediated selection in free-ranging elk populations infected by chronic wasting disease

Autor: Katherine I. O'Rourke, William H Edwards, Ryan J. Monello, Mary E Wood, Nathan L. Galloway, Jenny G. Powers, Sally A. Madsen-Bouterse, Margaret A. Wild

Publikováno v: Proceedings of the National Academy of Sciences. 114:12208-12212

Pathogens can exert a large influence on the evolution of hosts via selection for alleles or genotypes that moderate pathogen virulence. Inconsistent interactions between parasites and the host genome, such as those resulting from genetic linkages an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51430453998a0ab8d31a3a1c665b087
https://doi.org/10.1073/pnas.1707807114

Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein

Autor: Rohana P. Dassanayake, Katherine I. O'Rourke, Sally A. Madsen-Bouterse, Dongyue Zhuang, Aru Balachandran, Gordon Mitchell, David A. Schneider

Publikováno v: The Journal of General Virology

Development of mice expressing either ovine (Tg338) or cervid (TgElk) prion protein (PrP) have aided in characterization of scrapie and chronic wasting disease (CWD), respectively. Experimental inoculation of sheep with CWD prions has demonstrated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9d97975d160e040aefdbcb02ae1c03
http://europepmc.org/articles/PMC5042132

Up-regulated expression of spherical body protein 2 truncated copy 11 in Babesia bovis is associated with reduced cytoadhesion to vascular endothelial cells

Autor: Daiane Patrícia Oldiges, Telmo Graça, Jacob M. Laughery, Carlos E. Suarez, Brian M. Cooke, David R. Allred, Massaro W. Ueti, Roberta M. O'Connor, Gina M Gallego-Lopez, Sally A. Madsen-Bouterse, Audrey O.T. Lau

Publikováno v: International journal for parasitology. 49(2)

The factors involved in gain or loss of virulence in Babesia bovis are unknown. Spherical body protein 2 truncated copy 11 (sbp2t11) transcripts in B. bovis were recently reported to be a marker of attenuation for B. bovis strains. Increased cytoadhe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003c63541f82e48ccc72b094ace27430
https://pubmed.ncbi.nlm.nih.gov/30367864