Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Autor: Robson, Samuel C., Loman, Nicholas J., Connor, Thomas R., Golubchik, Tanya, Martinez Nunez, Rocio T., Ludden, Catherine, Corden, Sally, Johnston, Ian, Bonsall, David, Smith, Colin P., Awan, Ali R., Bucca, Giselda, Torok, M. Estee, Saeed, Kordo, Prieto, Jacqui A., Jackson, David K., Hamilton, William L., Snell, Luke B., Moore, Catherine, Harrison, Ewan M., Goncalves, Sonia, Fairley, Derek J., Loose, Matthew W., Watkins, Joanne, Livett, Rich, Moses, Samuel, Amato, Roberto, Nicholls, Sam, Bull, Matthew, Smith, Darren L., Barrett, Jeff, Aanensen, David M., Curran, Martin D., Parmar, Surendra, Aggarwal, Dinesh, Shepherd, James G., Parker, Matthew D., Glaysher, Sharon, Bashton, Matthew, Underwood, Anthony P., Pacchiarini, Nicole, Loveson, Katie F., Templeton, Kate E., Langford, Cordelia F., Sillitoe, John, de Silva, Thushan I., Wang, Dennis, Kwiatkowski, Dominic, Rambaut, Andrew, O’Grady, Justin, Cottrell, Simon, Holden, Matthew T.G., Thomson, Emma C., Osman, Husam, Andersson, Monique, Chauhan, Anoop J., Hassan-Ibrahim, Mohammed O., Lawniczak, Mara, Alderton, Alex, Chand, Meera, Constantinidou, Chrystala, Unnikrishnan, Meera, Darby, Alistair C., Hiscox, Julian A., Paterson, Steve, Martincorena, Inigo, Volz, Erik M., Page, Andrew J., Pybus, Oliver G., Bassett, Andrew R., Ariani, Cristina V., Chapman, Michael H. Spencer, Li, Kathy K., Shah, Rajiv N., Jesudason, Natasha G., Taha, Yusri, McHugh, Martin P., Dewar, Rebecca, Jahun, Aminu S., McMurray, Claire, Pandey, Sarojini, McKenna, James P., Nelson, Andrew, Young, Gregory R., McCann, Clare M., Elliott, Scott, Lowe, Hannah, Temperton, Ben, Roy, Sunando, Price, Anna, Rey, Sara, Wyles, Matthew, Rooke, Stefan, Shaaban, Sharif, de Cesare, Mariateresa, Letchford, Laura, Silveira, Siona, Pelosi, Emanuela, Wilson-Davies, Eleri, Hosmillo, Myra, O’Toole, Áine, Hesketh, Andrew R., Stark, Richard, du Plessis, Louis, Ruis, Chris, Adams, Helen, Bourgeois, Yann, Michell, Stephen L., Grammatopoulos, Dimitris, Edgeworth, Jonathan, Breuer, Judith, Todd, John A., Fraser, Christophe, Buck, David, John, Michaela, Kay, Gemma L., Palmer, Steve, Peacock, Sharon J., Heyburn, David, Weldon, Danni, Robinson, Esther, McNally, Alan, Muir, Peter, Vipond, Ian B., Boyes, John, Sivaprakasam, Venkat, Salluja, Tranprit, Dervisevic, Samir, Meader, Emma J., Park, Naomi R., Oliver, Karen, Jeffries, Aaron R., Ott, Sascha, da Silva Filipe, Ana, Simpson, David A., Williams, Chris, Masoli, Jane A.H., Knight, Bridget A., Jones, Christopher R., Koshy, Cherian, Ash, Amy, Casey, Anna, Bosworth, Andrew, Ratcliffe, Liz, Xu-McCrae, Li, Pymont, Hannah M., Hutchings, Stephanie, Berry, Lisa, Jones, Katie, Halstead, Fenella, Davis, Thomas, Holmes, Christopher, Iturriza-Gomara, Miren, Lucaci, Anita O., Randell, Paul Anthony, Cox, Alison, Madona, Pinglawathee, Harris, Kathryn Ann, Brown, Julianne Rose, Mahungu, Tabitha W., Irish-Tavares, Dianne, Haque, Tanzina, Hart, Jennifer, Witele, Eric, Fenton, Melisa Louise, Liggett, Steven, Graham, Clive, Swindells, Emma, Collins, Jennifer, Eltringham, Gary, Campbell, Sharon, McClure, Patrick C., Clark, Gemma, Sloan, Tim J., Jones, Carl, Lynch, Jessica, Warne, Ben, Leonard, Steven, Durham, Jillian, Williams, Thomas, Haldenby, Sam T., Storey, Nathaniel, Alikhan, Nabil-Fareed, Holmes, Nadine, Moore, Christopher, Carlile, Matthew, Perry, 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Laia, Gilbert, Lauren, Graham, Lee, Cronin, Michelle, Kumziene-Summerhayes, Sara, Taylor, Sarah, Jones, Sophie, Groves, Danielle C., Zhang, Peijun, Gallis, Marta, Louka, Stavroula F., Starinskij, Igor, Jackson, Chris, Gourtovaia, Marina, Tonkin-Hill, Gerry, Lewis, Kevin, Tovar-Corona, Jaime M., James, Keith, Baxter, Laura, Alam, Mohammad T., Orton, Richard J., Hughes, Joseph, Vattipally, Sreenu, Ragonnet-Cronin, Manon, Nascimento, Fabricia F., Jorgensen, David, Boyd, Olivia, Geidelberg, Lily, Zarebski, Alex E., Raghwani, Jayna, Kraemer, Moritz U.G., Southgate, Joel, Lindsey, Benjamin B., Freeman, Timothy M., Keatley, Jon-Paul, Singer, Joshua B., de Oliveira Martins, Leonardo, Yeats, Corin A., Abudahab, Khalil, Taylor, Ben E.W., Menegazzo, Mirko, Danesh, John, Hogsden, Wendy, Eldirdiri, Sahar, Kenyon, Anita, Mason, Jenifer, Robinson, Trevor I., Holmes, Alison, Price, James, Hartley, John A., Curran, Tanya, Mather, Alison E., Shankar, Giri, Jones, Rachel, Howe, Robin, Morgan, Sian, 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Redshaw, Nicholas M., Lensing, Stefanie V., McCarthy, Shane, Makunin, Alex, Balcazar, Carlos E., Gallagher, Michael D., Williamson, Kathleen A., Stanton, Thomas D., Michelsen, Michelle L., Warwick-Dugdale, Joanna, Manley, Robin, Farbos, Audrey, Harrison, James W., Sambles, Christine M., Studholme, David J., Lackenby, Angie, Mbisa, Tamyo, Platt, Steven, Miah, Shahjahan, Bibby, David, Manso, Carmen, Hubb, Jonathan, Dabrera, Gavin, Ramsay, Mary, Bradshaw, Daniel, Schaefer, Ulf, Groves, Natalie, Gallagher, Eileen, Lee, David, Williams, David, Ellaby, Nicholas, Hartman, Hassan, Manesis, Nikos, Patel, Vineet, Ledesma, Juan, Twohig, Katherine A., Allara, Elias, Pearson, Clare, Cheng, Jeffrey K.J., Bridgewater, Hannah E., Frost, Lucy R., Taylor-Joyce, Grace, Brown, Paul E., Tong, Lily, Broos, Alice, Mair, Daniel, Nichols, Jenna, Carmichael, Stephen N., Smollett, Katherine L., Nomikou, Kyriaki, Aranday-Cortes, Elihu, Johnson, Natasha, Nickbakhsh, Seema, Vamos, Edith E., Hughes, Margaret, Rainbow, Lucille, Eccles, Richard, Nelson, Charlotte, Whitehead, Mark, Gregory, Richard, Gemmell, Matthew, Wierzbicki, Claudia, Webster, Hermione J., Fisher, Chloe L., Signell, Adrian W., Betancor, Gilberto, Wilson, Harry D., Nebbia, Gaia, Flaviani, Flavia, Cerda, Alberto C., Merrill, Tammy V., Wilson, Rebekah E., Cotic, Marius, Bayzid, Nadua, Thompson, Thomas, Acheson, Erwan, Rushton, Steven, O’Brien, Sarah, Baker, David J., Rudder, Steven, Aydin, Alp, Sang, Fei, Debebe, Johnny, Francois, Sarah, Vasylyeva, Tetyana I., Zamudio, Marina Escalera, Gutierrez, Bernardo, Marchbank, Angela, Maksimovic, Joshua, Spellman, Karla, McCluggage, Kathryn, Morgan, Mari, Beer, Robert, Afifi, Safiah, Workman, Trudy, Fuller, William, Bresner, Catherine, Angyal, Adrienn, Green, Luke R., Parsons, Paul J., Tucker, Rachel M., Brown, Rebecca, Whiteley, Max, Bonfield, James, Puethe, Christoph, Whitwham, Andrew, Liddle, Jennifier, Rowe, Will, Siveroni, Igor, Le-Viet, Thanh, Gaskin, Amy, Johnson, Rob, Abnizova, Irina, Ali, Mozam, Allen, Laura, Anderson, Ralph, Ariani, Cristina, Austin-Guest, Siobhan, Bala, Sendu, Barrett, Jeffrey, Bassett, Andrew, Battleday, Kristina, Beal, James, Beale, Mathew, Bellany, Sam, Bellerby, Tristram, Bellis, Katie, Berger, Duncan, Berriman, Matt, Bevan, Paul, Binley, Simon, Bishop, Jason, Blackburn, Kirsty, Boughton, Nick, Bowker, Sam, Brendler-Spaeth, Timothy, Bronner, Iraad, Brooklyn, Tanya, Buddenborg, Sarah Kay, Bush, Robert, Caetano, Catarina, Cagan, Alex, Carter, Nicola, Cartwright, Joanna, Monteiro, Tiago Carvalho, Chapman, Liz, Chillingworth, Tracey-Jane, Clapham, Peter, Clark, Richard, Clarke, Adrian, Clarke, Catriona, Cole, Daryl, Cook, Elizabeth, Coppola, Maria, Cornell, Linda, Cornwell, Clare, Corton, Craig, Crackett, Abby, Cranage, Alison, Craven, Harriet, Craw, Sarah, Crawford, Mark, Cutts, Tim, Dabrowska, Monika, Davies, Matt, Dawson, Joseph, Day, Callum, Densem, Aiden, Dibling, Thomas, Dockree, Cat, Dodd, David, Dogga, Sunil, Dorman, Matthew, Dougan, Gordon, Dougherty, Martin, Dove, Alexander, Drummond, Lucy, Dudek, Monika, Durrant, Laura, Easthope, Elizabeth, Eckert, Sabine, Ellis, Pete, Farr, Ben, Fenton, Michael, Ferrero, Marcella, Flack, Neil, Fordham, Howerd, Forsythe, Grace, Francis, Matt, Fraser, Audrey, Freeman, Adam, Galvin, Anastasia, Garcia-Casado, Maria, Gedny, Alex, Girgis, Sophia, Glover, James, Gould, Oliver, Gray, Andy, Gray, Emma, Griffiths, Coline, Gu, Yong, Guerin, Florence, Hamilton, Will, Hanks, Hannah, Harrison, Ewan, Harrott, Alexandria, Harry, Edward, Harvison, Julia, Heath, Paul, Hernandez-Koutoucheva, Anastasia, Hobbs, Rhiannon, Holland, Dave, Holmes, Sarah, Hornett, Gary, Hough, Nicholas, Huckle, Liz, Hughes-Hallet, Lena, Hunter, Adam, Inglis, Stephen, Iqbal, Sameena, Jackson, Adam, Jackson, David, Verdejo, Carlos Jimenez, Jones, Matthew, Kallepally, Kalyan, Kay, Keely, Keatley, Jon, Keith, Alan, King, Alison, Kitchin, Lucy, Kleanthous, Matt, Klimekova, Martina, Korlevic, Petra, Krasheninnkova, Ksenia, Lane, Greg, Langford, Cordelia, Laverack, Adam, Law, Katharine, Lensing, Stefanie, Lewis-Wade, Amanah, Liddle, Jennifer, Lin, Quan, Lindsay, Sarah, Linsdell, Sally, Long, Rhona, Lovell, Jamie, Lovell, Jon, Mack, James, Maddison, Mark, Makunin, Aleksei, Mamun, Irfan, Mansfield, Jenny, Marriott, Neil, Martin, Matt, Mayho, Matthew, McClintock, Jo, McHugh, Sandra, MapcMinn, Liz, Meadows, Carl, Mobley, Emily, Moll, Robin, Morra, Maria, Morrow, Leanne, Murie, Kathryn, Nash, Sian, Nathwani, Claire, Naydenova, Plamena, Neaverson, Alexandra, Nerou, Ed, Nicholson, Jon, Nimz, Tabea, Noell, Guillaume G., O’Meara, Sarah, Ohan, Valeriu, Olney, Charles, Ormond, Doug, Oszlanczi, Agnes, Pang, Yoke Fei, Pardubska, Barbora, Park, Naomi, Parmar, Aaron, Patel, Gaurang, Payne, Maggie, Peacock, Sharon, Petersen, Arabella, Plowman, Deborah, Preston, Tom, Quail, Michael, Rance, Richard, Rawlings, Suzannah, Redshaw, Nicholas, Reynolds, Joe, Reynolds, Mark, Rice, Simon, Richardson, Matt, Roberts, Connor, Robinson, Katrina, Robinson, Melanie, Robinson, David, Rogers, Hazel, Rojo, Eduardo Martin, Roopra, Daljit, Rose, Mark, Rudd, Luke, Sadri, Ramin, Salmon, Nicholas, Saul, David, Schwach, Frank, Seekings, Phil, Simms, Alison, Sinnott, Matt, Sivadasan, Shanthi, Siwek, Bart, Sizer, Dale, Skeldon, Kenneth, Skelton, Jason, Slater-Tunstill, Joanna, Sloper, Lisa, Smerdon, Nathalie, Smith, Chris, Smith, Christen, Smith, James, Smith, Katie, Smith, Michelle, Smith, Sean, Smith, Tina, Sneade, Leighton, Soria, Carmen Diaz, Sousa, Catarina, Souster, Emily, Sparkes, Andrew, Spencer-Chapman, Michael, Squares, Janet, Stanley, Robert, Steed, Claire, Stickland, Tim, Still, Ian, Stratton, Mike, Strickland, Michelle, Swann, Allen, Swiatkowska, Agnieszka, Sycamore, Neil, Swift, Emma, Symons, Edward, Szluha, Suzanne, Taluy, Emma, Tao, Nunu, Taylor, Katy, Taylor, Sam, Thompson, Stacey, Thompson, Mark, Thomson, Mark, Thomson, Nicholas, Thurston, Scott, Toombs, Dee, Topping, Benjamin, Tovar-Corona, Jaime, Ungureanu, Daniel, Uphill, James, Urbanova, Jana, Van, Philip Jansen, Vancollie, Valerie, Voak, Paul, Walker, Danielle, Walker, Matthew, Waller, Matt, Ward, Gary, Weatherhogg, Charlie, Webb, Niki, Wells, Alan, Wells, Eloise, Westwood, Luke, Whipp, Theo, Whiteley, Thomas, Whitton, Georgia, Widaa, Sara, Williams, Mia, Wilson, Mark, Wright, Sean, Meng, Bo, Kemp, Steven A., Papa, Guido, Datir, Rawlings, Ferreira, Isabella A.T.M., Marelli, Sara, Harvey, William T., Lytras, Spyros, Mohamed, Ahmed, Gallo, Giulia, Thakur, Nazia, Collier, Dami A., Mlcochova, Petra, Duncan, Lidia M., Carabelli, Alessandro M., Kenyon, Julia C., Lever, Andrew M., De Marco, Anna, Saliba, Christian, Culap, Katja, Cameroni, Elisabetta, Matheson, Nicholas J., Piccoli, Luca, Corti, Davide, James, Leo C., Robertson, David L., Bailey, Dalan, Gupta, Ravindra K.

Publikováno v: In Cell Reports 29 June 2021 35(13)