Production Process Optimization of Recombinant Erwinia carotovora l-Asparaginase II in Escherichia coli Fed-Batch Cultures and Analysis of Antileukemic Potential.

Autor: de Andrade BC; National Institute of Science and Technology in Tuberculosis, Research Center for Molecular and Functional Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.; Graduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil., Renard G; Quatro G Pesquisa & Desenvolvimento Ltd., Porto Alegre, Rio Grande do Sul 90619-900, Brazil., Gennari A; Food Biotechnology Laboratory, Biotechnology Graduate Program, University of Vale do Taquari (UNIVATES), Lajeado, Rio Grande do Sul 95914-014, Brazil., Artico LL; Centro Infantil Boldrini, Campinas, São Paulo 13083-210, Brazil.; Graduate Program in Genetics and Molecular Biology, Biology Institute, State University of Campinas, Campinas, São Paulo 13083-970, Brazil., Júnior JRT; Centro Infantil Boldrini, Campinas, São Paulo 13083-210, Brazil.; Graduate Program in Genetics and Molecular Biology, Biology Institute, State University of Campinas, Campinas, São Paulo 13083-970, Brazil., Kuhn D; Food Biotechnology Laboratory, Biotechnology Graduate Program, University of Vale do Taquari (UNIVATES), Lajeado, Rio Grande do Sul 95914-014, Brazil., Salles PPZ; Centro Infantil Boldrini, Campinas, São Paulo 13083-210, Brazil.; Graduate Program in Genetics and Molecular Biology, Biology Institute, State University of Campinas, Campinas, São Paulo 13083-970, Brazil., Volken de Souza CF; Food Biotechnology Laboratory, Biotechnology Graduate Program, University of Vale do Taquari (UNIVATES), Lajeado, Rio Grande do Sul 95914-014, Brazil., Roth G; Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil., Chies JM; Quatro G Pesquisa & Desenvolvimento Ltd., Porto Alegre, Rio Grande do Sul 90619-900, Brazil., Yunes JA; Centro Infantil Boldrini, Campinas, São Paulo 13083-210, Brazil.; Department of Medical Genetics, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo 13083-970, Brazil., Basso LA; National Institute of Science and Technology in Tuberculosis, Research Center for Molecular and Functional Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.; Graduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.; Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.

Publikováno v: ACS omega [ACS Omega] 2024 Aug 03; Vol. 9 (32), pp. 34951-34963. Date of Electronic Publication: 2024 Aug 03 (Print Publication: 2024).