Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming

Autor: Potts, MB, Siu, JJ, Price, JD, Salinas, RD, Cho, MJ, Ramos, AD, Hahn, J, Margeta, M, Oldham, MC, Lim, DA

Publikováno v: Neurosurgery, vol 75, iss 4
Potts, MB; Siu, JJ; Price, JD; Salinas, RD; Cho, MJ; Ramos, AD; et al.(2014). Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and brn4 as a factor for direct astrocyte-to-neuron reprogramming. Neurosurgery, 75(4), 472-482. doi: 10.1227/NEU.0000000000000452. UCSF: Retrieved from: http://www.escholarship.org/uc/item/935888z8

Copyright © 2014 by the Congress of Neurological Surgeons. BACKGROUND: Mixed lineage leukemia-1 (Mll1) epigenetically regulates gene expression patterns that specify cellular identity in both embryonic development and adult stem cell populations. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f1c722c8b683633143b36fdef5c01e7a
https://escholarship.org/uc/item/935888z8

Ventilation back ramp designed to prevent supperative donor sites and accelerate healing time.

Autor: Salinas RD, Hedman TL, Quick CD, Wolf SE, Holcomb JB

Publikováno v: Journal of Burn Care & Research; 2007 Mar Supplement, Vol. 28 Issue 2, pS109-S109, 1p

Molecular landscapes of human hippocampal immature neurons across lifespan.

Autor: Zhou Y; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Su Y; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li S; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China., Kennedy BC; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhang DY; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bond AM; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sun Y; Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jacob F; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lu L; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hu P; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Viaene AN; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Helbig I; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; The Epilepsy NeuroGenetics Initiative (ENGIN), Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biomedical and Health Informatics (DBHi), Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kessler SK; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lucas T; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Salinas RD; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gu X; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China., Chen HI; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wu H; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA.; The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kleinman JE; Lieber Institute for Brain Development, The Solomon H. Snyder Department of Neuroscience, Department of Neurology, and Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Hyde TM; Lieber Institute for Brain Development, The Solomon H. Snyder Department of Neuroscience, Department of Neurology, and Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Nauen DW; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Weinberger DR; Lieber Institute for Brain Development, The Solomon H. Snyder Department of Neuroscience, Department of Neurology, and Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Ming GL; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. gming@pennmedicine.upenn.edu.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA. gming@pennmedicine.upenn.edu.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. gming@pennmedicine.upenn.edu.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. gming@pennmedicine.upenn.edu., Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. shongjun@pennmedicine.upenn.edu.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA. shongjun@pennmedicine.upenn.edu.; The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. shongjun@pennmedicine.upenn.edu.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. shongjun@pennmedicine.upenn.edu.

Publikováno v: Nature [Nature] 2022 Jul; Vol. 607 (7919), pp. 527-533. Date of Electronic Publication: 2022 Jul 06.

Invited Review: Epigenetics in neurodevelopment.

Autor: Salinas RD; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA., Connolly DR; Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA, USA., Song H; Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; The Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2020 Feb; Vol. 46 (1), pp. 6-27. Date of Electronic Publication: 2020 Mar 09.

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.

Autor: Jacob F; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Salinas RD; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhang DY; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Nguyen PTT; Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Schnoll JG; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Wong SZH; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Thokala R; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA., Sheikh S; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Saxena D; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Prokop S; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Liu DA; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA., Qian X; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Bioengineering Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Petrov D; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA., Lucas T; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA., Chen HI; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA., Dorsey JF; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA., Christian KM; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Binder ZA; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA., Nasrallah M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA., Brem S; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA., O'Rourke DM; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: donald.orourke@pennmedicine.upenn.edu., Ming GL; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: ming@pennmedicine.upenn.edu., Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: shongjun@pennmedicine.upenn.edu.

Publikováno v: Cell [Cell] 2020 Jan 09; Vol. 180 (1), pp. 188-204.e22. Date of Electronic Publication: 2019 Dec 26.