Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.

Autor: Herpers B; OcellO BV, Leiden, The Netherlands.; Crown Bioscience Netherlands BV, Leiden, The Netherlands., Eppink B; Merus NV, Utrecht, The Netherlands., James MI; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain., Cortina C; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBERONC, Madrid, Spain., Cañellas-Socias A; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBERONC, Madrid, Spain., Boj SF; Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands., Hernando-Momblona X; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBERONC, Madrid, Spain., Glodzik D; Wellcome Sanger Institute, Hinxton, UK.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Roovers RC; Merus NV, Utrecht, The Netherlands., van de Wetering M; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands., Bartelink-Clements C; Merus NV, Utrecht, The Netherlands., Zondag-van der Zande V; Merus NV, Utrecht, The Netherlands., Mateos JG; OcellO BV, Leiden, The Netherlands.; Crown Bioscience Netherlands BV, Leiden, The Netherlands., Yan K; OcellO BV, Leiden, The Netherlands.; Crown Bioscience Netherlands BV, Leiden, The Netherlands., Salinaro L; OcellO BV, Leiden, The Netherlands., Basmeleh A; Merus NV, Utrecht, The Netherlands., Fatrai S; Merus NV, Utrecht, The Netherlands., Maussang D; Merus NV, Utrecht, The Netherlands., Lammerts van Bueren JJ; Merus NV, Utrecht, The Netherlands., Chicote I; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Serna G; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Cabellos L; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Medical Oncology Department, Vall d'Hebron University Hospital (HUVH), Barcelona, Spain., Ramírez L; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Medical Oncology Department, Vall d'Hebron University Hospital (HUVH), Barcelona, Spain., Nuciforo P; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Salazar R; Department of Medical Oncology, Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL)-CIBERONC, L'Hospitalet de Llobregat, Barcelona, Spain., Santos C; Department of Medical Oncology, Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL)-CIBERONC, L'Hospitalet de Llobregat, Barcelona, Spain., Villanueva A; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.; Xenopat SL, Parc Cientific de Barcelona (PCB), Barcelona, Spain., Stephan-Otto Attolini C; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain., Sancho E; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBERONC, Madrid, Spain., Palmer HG; CIBERONC, Madrid, Spain.; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Medical Oncology Department, Vall d'Hebron University Hospital (HUVH), Barcelona, Spain., Tabernero J; CIBERONC, Madrid, Spain.; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Medical Oncology Department, Vall d'Hebron University Hospital (HUVH), Barcelona, Spain., Stratton MR; Wellcome Sanger Institute, Hinxton, UK., de Kruif J; Merus NV, Utrecht, The Netherlands., Logtenberg T; Merus NV, Utrecht, The Netherlands., Clevers H; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands., Price LS; OcellO BV, Leiden, The Netherlands.; Crown Bioscience Netherlands BV, Leiden, The Netherlands., Vries RGJ; Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands., Batlle E; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain. eduard.batlle@irbbarcelona.org.; CIBERONC, Madrid, Spain. eduard.batlle@irbbarcelona.org.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. eduard.batlle@irbbarcelona.org., Throsby M; Merus NV, Utrecht, The Netherlands. M.Throsby@merus.nl.

Publikováno v: Nature cancer [Nat Cancer] 2022 Apr; Vol. 3 (4), pp. 418-436. Date of Electronic Publication: 2022 Apr 25.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Stem Cell Markers LGR5, LGR4 and Their Immediate Signalling Partners are Dysregulated in Preeclampsia.

Autor: Wong GP; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia. gpwong@student.unimelb.edu.au.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. gpwong@student.unimelb.edu.au., Hartmann S; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia.; Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association and Charitè Campus Buch, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; DZHK (German Center for Cardiovascular Research), partner site, Berlin, Germany., Nonn O; Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association and Charitè Campus Buch, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; DZHK (German Center for Cardiovascular Research), partner site, Berlin, Germany.; Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Cannon P; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Nguyen TV; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Kandel M; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., de Alwis N; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Murphy CN; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Pritchard N; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Dechend R; Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association and Charitè Campus Buch, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; DZHK (German Center for Cardiovascular Research), partner site, Berlin, Germany.; Department of Cardiology and Nephrology, HELIOS Klinikum, Berlin Buch, Germany., Hannan NJ; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Tong S; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Simmons DG; School of Biomedical Sciences, University of Queensland, Brisbane, Australia., Kaitu'u-Lino TJ; The Department of Obstetrics, Gynaecology and Newborn Health/Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia.; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia.

Publikováno v: Stem cell reviews and reports [Stem Cell Rev Rep] 2024 Dec 17. Date of Electronic Publication: 2024 Dec 17.

Glutathione: Role in Oxidative/Nitrosative Stress, Antioxidant Defense, and Treatments.

Autor: Raj Rai, Sristi¹ (AUTHOR), Bhattacharyya, Camelia¹ (AUTHOR), Sarkar, Anwita¹ (AUTHOR), Chakraborty, Surupa¹ (AUTHOR), Sircar, Esha¹ (AUTHOR), Dutta, Sreejita¹ (AUTHOR), Sengupta, Rajib¹ (AUTHOR) rajib4042@gmail.com

Publikováno v: ChemistrySelect. May2021, Vol. 6 Issue 18, p4566-4590. 25p.

Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants.

Autor: Jardi, F., Kelly, C., Teague, C., Fowler-Williams, H., Sevin, D. C., Rodrigues, D., Jo, H., Ferreira, S., Herpers, B., Van Heerden, M., de Kok, T., Pin, C., Lynch, A., Duckworth, C. A., De Jonghe, S., Lammens, L., Pritchard, D. M.

Publikováno v: Archives of Toxicology; Jan2023, Vol. 97 Issue 1, p235-254, 20p