Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Autor: Andrew Filer, Michael H Weisman, Judith A James, Kenneth Kalunian, Michelle A Petri, Chaim Putterman, H Michael Belmont, Ilfita Sahbudin, Karim Raza, Maria Dall'Era, Jill P Buyon, Diane L Kamen, Karen Salomon-Escoto, Kazuyoshi Ishigaki, Patrick Dunn, David Wofsy, Michele Bombardieri, Vivian Bykerk, Myles Lewis, Ming Wu, Soumya Raychaudhuri, Hemant Suryawanshi, Thomas Tuschl, Christopher Ritchlin, Maureen McMahon, Jennifer Grossman, Philip M Carlucci, Alessandra Nerviani, Peter M Izmirly, Fan Zhang, Felice Rivellese, Joan Bathon, Zhu Zhu, Qian Xiao, Jessica Li, Holden Maecker, Nir Hacohen, Rong Mao, Jennifer Anolik, Javier Rangel-Moreno, Nida Meednu, Susan Goodman, Lindsy Forbess, Mariko Ishimori, Kevin Deane, David Hildeman, Yuhong Li, Laura Hughes, Robert Clancy, ANNE DAVIDSON, Matthias Kretzler, Larry Moreland, Harris Perlman, Peter Gregersen, Celine C Berthier, Andrea Fava, David Boyle, Derek M Fine, Ami Ben-Artzi, P J Utz, Melanie Smith, Beatrice Goilav, Carla Cuda, Andrew McDavid, Deepak A Rao, Joshua Keegan, Ilya Korsunsky, Joel Guthridge, Kevin Wei, Arnon Arazi, Thomas Eisenhaure, Michael Brenner, Susan Macwana, Pavel Morozov, Manjunath Kustagi, Gerald Watts, Kristina K Deonaraine, Jose Monroy-Trujillo, Mohamed G Atta, Kristin Haag, William Apruzzese, Sean Connery, Fernanda Payan-Schober, Kerry Cho, Jennifer Goff, Aparna Nathan, Joseph Mears, Nghia Millard, Kathryn Weinand, Saori Sakaue, Bill Robinson, Wade DeJager, Louis Bridges, Laura Donlin, Edward DiCarlo, Amit Lakhanpal, Heather Sherman, Anvita Singaraju, Lorien Shakib, Brendan Boyce, Darren Tabechian, Jen Albrecht, James Lederer, A Helena Jonsson, Daimon Simmons, Gregory Keras, Adam Chicoine, Zhihan Jian Li, Mandy McGeachy, Gary Firestein, Arnold Ceponis, Diane Horowitz, Salina Dominguez, Arthur Mandelin, Anjali Thakrar, Mike Holers, Jennifer Seifert, Constanino Pitzalis, Ellen Gravallese, Jennifer Barnas, Raymond Hsu, Steven Woodle, Paul Hoover, Michael Peters, Tony Jones, David Lieb, Jeffrey Hodgin, Raji Menon

Publikováno v: Lupus Science and Medicine, Vol 8, Iss 1 (2021)

Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating i

Externí odkaz: https://doaj.org/article/e3722c73b6ce45bba6e56c13af3b5745

The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response

Autor: Salina Dominguez, Anna B. Montgomery, G. Kenneth Haines, Christina L. Bloomfield, Carla M. Cuda

Publikováno v: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-16 (2017)

Abstract Background Caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, but maintains functions beyond cell death that involve suppression of receptor-interacting serine-threonine kinases (RIPKs). A genome-wide assoc

Externí odkaz: https://doaj.org/article/e1109fb24c404460a63bae8ca6cc6799

Tissue-resident, extravascular CD64-Ly6C- population forms a critical barrier for inflammation in the synovium

Autor: Harris Perlman, Salina Dominguez, Ankit Bharat, G. R. S. Bundinger, Deborah R. Winter, M. G. Gurra, Carla M. Cuda, Alexander V. Misharin, Mahzad Akbarpour, G. Gadhvi, M. G. Mayr, Anna B. Montgomery, Hadijat M. Makinde, Shang Yang Chen

Monocytes are one of the most abundant immune cells infiltrating the inflamed organs. However, the majority of studies on monocytes focus on circulating cells, rather than those in the tissue. Here, we identify and characterize an intravascular (i.v.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b24a3ad25104b9ce060c51fbd43a4cd4
https://doi.org/10.1101/2021.02.25.432850

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis

Autor: Salina Dominguez, Elizabeth T. Bartom, E. Bacalao, Mary Carns, S. Louis Bridges, Laura B. Hughes, Anna B. Montgomery, John P. Atkinson, Monique Hinchcliff, Eric Ruderman, Robert W. Ike, Kristine Phillips, G. R. Scott Budinger, Kerry Wright, Deborah Parks, Arthur M. Mandelin, Vince K. Morgan, Richard M. Pope, Alexander V. Misharin, Philip J. Homan, Kathleen Aren, Alexander M. Shaffer, Carla M. Cuda, Anjali Thakrar, Christopher D. Buckley, Joan M. Bathon, Harris Perlman, Stephen Kelly, Eric L. Matteson, David A. Fox, Costantino Pitzalis, Andrew Filer, Laura Geraldino-Pardilla, Hiam Abdala-Valencia, Deborah R. Winter, Jongmin Lee

Publikováno v: Arthritis & Rheumatology. 70:841-854

Objective Currently, there are no reliable biomarkers for predicting therapeutic response in patients with rheumatoid arthritis (RA). The synovium may unlock critical information for determining efficacy, since a reduction in the numbers of sublining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b17ff90942cc5ac239dcc034843fd7
https://doi.org/10.1002/art.40453

Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model

Autor: Pierre Duffau, Carla M. Cuda, Harris Perlman, Lisa M. Rice, G. Kenneth Haines, Ian R. Rifkin, Ellen M. Gravallese, Tamar Aprahamian, Paul A. Monach, Salina Dominguez, Rebecca Baum, Kei Yasuda, Hanni Menn-Josephy, Robert Lafyatis, Christophe Richez, Ramon G. Bonegio, Amanda A. Watkins

Publikováno v: Arthritis & Rheumatology. 67:3146-3157

Objective Polymorphisms in the transcription factor interferon regulatory factor 5 (IRF5) are associated with an increased risk of developing rheumatoid arthritis (RA). This study was undertaken to determine the role of IRF5 in a mouse model of arthr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38f575b7af6607bae3aed6d32af42edc
https://doi.org/10.1002/art.39321