Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Salina, Chan"'
Autor:
Chien‐Kuang Cornelia Ding, Salina Chan, Julie Mak, Sarah E Umetsu, Jeffry P Simko, Roberto Ruiz‐Cordero, Tara Saunders, Emily Chan
Publikováno v:
HistopathologyReferences. 81(2)
Mutations and epimutations in genes encoding the succinate dehydrogenase complex (SDHx) are associated with multiple tumour types in which identification of SDH-deficiency has significant management implications. Immunohistochemistry (IHC) for the su
Autor:
Taylor Sittler, O Leitner, E Gil, SB Adams, Lauren Ryan, Beth Crawford, L.J. van 't Veer, J. van den Akker, Salina Chan
Publikováno v:
Cancer Research. 77:P3-08
Background Among women with an elevated risk of hereditary breast and ovarian cancer who previously tested negative for pathogenic mutations in BRCA1 and BRCA2, a subset remain at increased risk of having hereditary breast, ovarian or other cancers,
Autor:
Margaret A. Tempero, Amie Blanco, Salina Chan, Evan J. Walker, Eric A. Collisson, Julia Carnevale, Christina Pedley, Andrew H. Ko
Publikováno v:
Familial cancer. 18(2)
Hereditary predisposition is estimated to account for 10% of all pancreatic cancer cases. However, referral patterns and clinical workflow for germline testing in this disease differ significantly by institution, and many at-risk patients may not und
Autor:
Laura van 't Veer, Lauren Ryan, Taylor Sittler, Ofri Leitner, Sophie B. Adams, Beth Crawford, Salina Chan, Jeroen van den Akker, Elad Gil
Publikováno v:
Breast cancer research and treatment, vol 163, iss 2
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment
Purpose Many women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738ff5fb7ed050249334f6fb66882aa8
https://escholarship.org/uc/item/04j9x65s
https://escholarship.org/uc/item/04j9x65s
Autor:
Keelia Rhoads, Rachel A. Greenup, E. Shelley Hwang, Robin H. King, Salina Chan, Jane McLennan, Tracey Leedom, Adam H. Buchanan, Beth Crawford, P. Kelly Marcom, Wendy Lorizio
Publikováno v:
Annals of Surgical Oncology. 20:3254-3258
Revised NCCN guidelines recommend that women ≤60 years with triple-negative breast cancer (TNBC) be referred for consideration of genetic counseling. Small, homogeneous samples have limited evaluation of BRCA mutation prevalence among different eth
Autor:
Christina Pedley, Andrew H. Ko, Julia Carnevale, Amie Blanco, Eric A. Collisson, Salina Chan, Evan J. Walker
Publikováno v:
Journal of Clinical Oncology. 36:1591-1591
1591Background: Hereditary predisposition is estimated to account for 10% of all PC cases. Identification of pathogenic germline mutations can inform not only screening recommendations for family m...
Autor:
Nobuhiko Kayagaki, Yan Qu, Thomas Henry, Salina Chan, Petr Broz, Jonathan W. Jones, Denise M. Monack, Jennifer Dong, Kim Newton, Meron Roose-Girma, Vishva M. Dixit, Karen O'Rourke
Publikováno v:
Proceedings of the National Academy of Sciences. 107:9771-9776
Macrophages respond to cytosolic nucleic acids by activating cysteine protease caspase-1 within a complex called the inflammasome. Subsequent cleavage and secretion of proinflammatory cytokines IL-1β and IL-18 are critical for innate immunity. Here,
Autor:
Julia Whitman, Salina Chan, Emily K. Bergsland, Mallika Sachdev Dhawan, Li Zhang, Amie Blanco, Alan Paciorek, Jacqueline T. DesJardin, Brandon E. Shih
Publikováno v:
Journal of Clinical Oncology. 36:226-226
226 Background: Neuroendocrine tumors (NETs) are known to be associated with hereditary syndromes stemming from MEN1, VHL, SDH or TSC mutations. Recent data suggest that additional germline mutations may be relevant, implying a role of germline testi
Autor:
Genhong Cheng, Nobuhiko Kayagaki, Eric M. Pietras, Zemin Zhang, David Arnott, Qui Phung, Ruchir Chaudhari, Salina Chan, Vishva M. Dixit, Karen O'Rourke, J. Fernando Bazan, Michael Eby, Casey Quan
Publikováno v:
Science. 318:1628-1632
Production of type I interferon (IFN-I) is a critical host defense triggered by pattern-recognition receptors (PRRs) of the innate immune system. Deubiquitinating enzyme A (DUBA), an ovarian tumor domain-containing deubiquitinating enzyme, was discov
Autor:
Kelly L, Bolton, Georgia, Chenevix-Trench, Cindy, Goh, Siegal, Sadetzki, Susan J, Ramus, Beth Y, Karlan, Diether, Lambrechts, Evelyn, Despierre, Daniel, Barrowdale, Lesley, McGuffog, Sue, Healey, Douglas F, Easton, Olga, Sinilnikova, Javier, Benítez, María J, García, Susan, Neuhausen, Mitchell H, Gail, Patricia, Hartge, Susan, Peock, Debra, Frost, D Gareth, Evans, Rosalind, Eeles, Andrew K, Godwin, Mary B, Daly, Ava, Kwong, Edmond S K, Ma, Conxi, Lázaro, Ignacio, Blanco, Marco, Montagna, Emma, D'Andrea, Maria Ornella, Nicoletto, Sharon E, Johnatty, Susanne Krüger, Kjær, Allan, Jensen, Estrid, Høgdall, Ellen L, Goode, Brooke L, Fridley, Jennifer T, Loud, Mark H, Greene, Phuong L, Mai, Angela, Chetrit, Flora, Lubin, Galit, Hirsh-Yechezkel, Gord, Glendon, Irene L, Andrulis, Amanda E, Toland, Leigha, Senter, Martin E, Gore, Charlie, Gourley, Caroline O, Michie, Honglin, Song, Jonathan, Tyrer, Alice S, Whittemore, Valerie, McGuire, Weiva, Sieh, Ulf, Kristoffersson, Håkan, Olsson, Åke, Borg, Douglas A, Levine, Linda, Steele, Mary S, Beattie, Salina, Chan, Robert L, Nussbaum, Kirsten B, Moysich, Jenny, Gross, Ilana, Cass, Christine, Walsh, Andrew J, Li, Ronald, Leuchter, Ora, Gordon, Montserrat, Garcia-Closas, Simon A, Gayther, Stephen J, Chanock, Antonis C, Antoniou, Paul D P, Pharoah, Roger, Milne
Publikováno v:
JAMA. 307(4)
Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 rema