Data from HER2-Targeted Polyinosine/Polycytosine Therapy Inhibits Tumor Growth and Modulates the Tumor Immune Microenvironment

Autor: Alexander Levitzki, Mark X. Sliwkowski, Anat Globerson Levin, Gabriel Mizraji, Shang-Fan Yu, Jeffrey Lau, Nufar Edinger, Shoshana Klein, Anna Sagalov, Salim Joubran, Alexei Shir, Maya Zigler

The development of targeted therapies that affect multiple signaling pathways and stimulate antitumor immunity is greatly needed. About 20% of patients with breast cancer overexpress HER2. Small molecules and antibodies targeting HER2 convey some sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e4fb8c734f4b546b57e4f28878440a6
https://doi.org/10.1158/2326-6066.c.6548633.v1

Supplementary Figure S3 from HER2-Targeted Polyinosine/Polycytosine Therapy Inhibits Tumor Growth and Modulates the Tumor Immune Microenvironment

Autor: Alexander Levitzki, Mark X. Sliwkowski, Anat Globerson Levin, Gabriel Mizraji, Shang-Fan Yu, Jeffrey Lau, Nufar Edinger, Shoshana Klein, Anna Sagalov, Salim Joubran, Alexei Shir, Maya Zigler

Supplementary Figure demonstrating the effect of pIC/PPHAffibody treatment on RENCA HER2 cell survival in vitro and in vivo by immunohistochemistry staining for c-caspase-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c327d560c5eb757ca4aa54cf6e444d
https://doi.org/10.1158/2326-6066.22538003.v1

Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing

Autor: Dolev Zamir, Israel Alshanski, Shir Zorsky, Moshe Bentolila, Salim Joubran, Chaim Gilon, Agata Gitlin-Domagalska, Mattan Hurevich

Publikováno v: Organic Process Research & Development. 22:1318-1322

The brittle nature of the polymer beads used in SPPS dictates mild mixing techniques with low mass transfer. We demonstrate that vigorous overhead mechanical stirring with superior mass transfer properties kept the beads intact and significantly acce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fe2fb663a7902c5973fa691e79e52bb
https://doi.org/10.1021/acs.oprd.8b00225

HER2-Targeted Polyinosine/Polycytosine Therapy Inhibits Tumor Growth and Modulates the Tumor Immune Microenvironment

Autor: Mark X. Sliwkowski, Alexander Levitzki, Nufar Edinger, Anna Sagalov, Gabriel Mizraji, Shoshana Klein, Shang-Fan Yu, Anat Levin, Alexei Shir, Jeffrey Lau, Maya Zigler, Salim Joubran

Publikováno v: Cancer Immunology Research. 4:688-697

The development of targeted therapies that affect multiple signaling pathways and stimulate antitumor immunity is greatly needed. About 20% of patients with breast cancer overexpress HER2. Small molecules and antibodies targeting HER2 convey some sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59652d5197df25f5584870e809bd783a
https://doi.org/10.1158/2326-6066.cir-15-0203

Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: The HIV-1 CD4:gp120 paradigm

Autor: Salim Joubran, Laurence Briant-Longuet, Noam S. Freeman, Mattan Hurevich, Martine Bardy, Amnon Hoffman, Christian Devaux, Elena Britan-Rosich, Chaim Gilon, Avi Swed, Moshe Kotler, Shira Cohen

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2010, 18 (15), pp.5754-5761. ⟨10.1016/j.bmc.2010.04.053⟩

International audience; Rational conversion of noncontinuous active regions of proteins into a small orally bioavailable molecule is crucial for the discovery of new drugs based on inhibition of protein-protein interactions. We developed a method tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509709cec96f1ac268e954364040c634
https://hal.archives-ouvertes.fr/hal-00505767