Data from Oncogenic B-RAF Signaling in Melanoma Impairs the Therapeutic Advantage of Autophagy Inhibition

Autor: Penny E. Lovat, Mauro Piacentini, Gian Maria Fimia, Christopher P.F. Redfern, Salim Al Sabah, Nicola Ellis, David S. Hill, Laura Falasca, Vittoria Pagliarini, Shaun Martin, Marco Corazzari, Jane L. Armstrong

Purpose: Metastatic melanoma is characterized by extremely poor survival rates and hence novel therapies are urgently required. The ability of many anticancer drugs to activate autophagy, a lysosomal-mediated catabolic process which usually promotes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d0cd1d4a9abe45d1cc6ca995ba2b2e
https://doi.org/10.1158/1078-0432.c.6519183

Exceptional preservation of a prehistoric human brain from Heslington, Yorkshire, UK

Autor: Stephen Buckley, Keri A. Brown, Terry O'Connor, Konrad M. Dorling, Axel Petzold, Andy Gledhill, Salim Al-Sabah, Brendan J. Keely, Jane Thomas-Oates, Esam M. A. Ali, Jo Buckberry, J. Denton, Danish Anwar, Phil Duffey, David King, Robert C. Janaway, Ed Bergström, Peter Gardner, Sonia O'Connor, Adam Dowle, Jerry Thomas, Elsa Correia Faria, Matthew J. Collins, Andrew Wilson, Kimberley A. Shackleton, Karl Heaton, Martin G. Rumsby, Maria-Raimonda Usai, Anthony Masinton, Carl Heron, Howell G. M. Edwards, Kirsty Penkman, Holger Schutkowski, Matthew D. Pickering

Publikováno v: O'Connor, S, Ali, E, Al-Sabah, S, Anwar, D, Bergstrom, E, Brown, K A, Buckberry, J, Buckley, S, Collins, M, Denton, J, Dorling, K M, Dowle, A, Duffey, P, Edwards, H G M, Faria, E C, Gardner, P, Gledhill, A, Heaton, K, Heron, C, Janaway, R, Keely, B J, King, D, Masinton, A, Penkman, K, Petzold, A F S, Pickering, M D, Rumsby, M, Schutkowski, H, Shackleton, K A, Thomas, J, Thomas-Oates, J, Usai, M R, Wilson, A S & O'Connor, T 2011, ' Exceptional preservation of a prehistoric human brain from Heslington, Yorkshire, UK ', Journal of Archaeological Science, vol. 38, no. 7, pp. 1641-1654 . https://doi.org/10.1016/j.jas.2011.02.030
Journal of Archaeological Science, 38(7), 1641-1654. Academic Press Inc.

Archaeological work in advance of construction at a site on the edge of York, UK, yielded human remains of prehistoric to Romano-British date. Amongst these was a mandible and cranium, the intra-cranial space of which contained shrunken but macroscop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f1588be2f19dfa53e26e27579a8c9c
https://hdl.handle.net/1871/37560