Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Salil S. Bhate"'
Autor:
Michael Y. Lee, Jacob S. Bedia, Salil S. Bhate, Graham L. Barlow, Darci Phillips, Wendy J. Fantl, Garry P. Nolan, Christian M. Schürch
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Algorithmic cellular segmentation is an essential step for the quantitative analysis of highly multiplexed tissue images. Current segmentation pipelines often require manual dataset annotation and additional training, significant
Externí odkaz:
https://doaj.org/article/347f6e2534b248438390ec26d6ecd71e
Autor:
Darci Phillips, Magdalena Matusiak, Belén Rivero Gutierrez, Salil S. Bhate, Graham L. Barlow, Sizun Jiang, Janos Demeter, Kimberly S. Smythe, Robert H. Pierce, Steven P. Fling, Nirasha Ramchurren, Martin A. Cheever, Yury Goltsev, Robert B. West, Michael S. Khodadoust, Youn H. Kim, Christian M. Schürch, Garry P. Nolan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
PD-1 blockade is effective for only a subset of patients with cutaneous T cell lymphomas. Here, the authors report a spatial biomarker that uses immune and cancer cell topography to predict response to PD-1 blockade in this disease.
Externí odkaz:
https://doaj.org/article/185b95b3ae0241efb2f75ef0ed8fba8c
Autor:
Aaron T. Mayer, Derek R. Holman, Anav Sood, Utkarsh Tandon, Salil S. Bhate, Sunil Bodapati, Graham L. Barlow, Jeff Chang, Sarah Black, Erica C. Crenshaw, Alexander N. Koron, Sarah E. Streett, Sanjiv S. Gambhir, William J. Sandborn, Brigid S. Boland, Trevor Hastie, Robert Tibshirani, John T. Chang, Garry P. Nolan, Christian M. Schürch, Stephan Rogalla
Publikováno v:
Science Advances. 9
Although literature suggests that resistance to TNF inhibitor (TNFi) therapy in patients with ulcerative colitis (UC) is partially linked to immune cell populations in the inflamed region, there is still substantial uncertainty underlying the relevan
We develop a mathematical theory proposing that complex molecular phenotypes (CMPs, e.g., single-cell gene expression distributions and tissue organization) are produced from templates in the genome. We validate our theory using a procedure termed Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a988562b1aaed4e6229b91b659801de3
https://doi.org/10.1101/2022.08.15.503769
https://doi.org/10.1101/2022.08.15.503769
Autor:
Tala Shekarian, Carl P. Zinner, Ewelina M. Bartoszek, Wandrille Duchemin, Anna T. Wachnowicz, Sabrina Hogan, Manina M. Etter, Julia Flammer, Chiara Paganetti, Tomás A. Martins, Philip Schmassmann, Steven Zanganeh, Francois Le Goff, Manuele G. Muraro, Marie-Françoise Ritz, Darci Phillips, Salil S. Bhate, Graham L. Barlow, Garry P. Nolan, Christian M. Schürch, Gregor Hutter
Publikováno v:
Science advances. 8(26)
Recent therapeutic strategies for glioblastoma (GBM) aim at targeting immune tumor microenvironment (iTME) components to induce antitumoral immunity. A patient-tailored, ex vivo drug testing and response analysis platform for GBM would facilitate per
Autor:
Gustavo Vazquez, Salil S. Bhate, Yury Goltsev, Garry P. Nolan, Sarah Black, Christian M. Schürch, Nikolay Samusik, Graham L. Barlow, Julia Kennedy-Darling, John W. Hickey, Vishal G. Venkataraaman
Publikováno v:
European Journal of Immunology
Multiparameter tissue imaging enables analysis of cell‐cell interactions in situ, the cellular basis for tissue structure, and novel cell types that are spatially restricted, giving clues to biological mechanisms behind tissue homeostasis and disea
Autor:
Kimberly S. Smythe, Darci J. Phillips, Robert H. Pierce, Salil S. Bhate, Yury Goltsev, Youn H. Kim, Magdalena Matusiak, Christian M. Schürch, Steven P. Fling, Garry P. Nolan, Martin A. Cheever, Janos Demeter, Graham L. Barlow, Sizun Jiang, Nirasha Ramchurren, Robert West, Michael S. Khodadoust, Belén Rivero Gutierrez
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically unmet need for predictive biomarkers of response. Herein, we perform C
Autor:
Garry P. Nolan, Chin-Min Kimmy Ho, Ahmet F. Coskun, Graham L. Barlow, Chuck Hitzman, Guojun Han, Sizun Jiang, Shih-Yu Chen, Xavier Rovira-Clavé, Felice-Alessio Bava, Bokai Zhu, Salil S. Bhate, Yunhao Bai
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Simultaneous visualization of the relationship between multiple biomolecules and their ligands or small molecules at the nanometer scale in cells will enable greater understanding of how biological processes operate. We present here high-definition m
Autor:
Utkarsh Tandon, Sarah Black, Erica Crenshaw, Christian M. Schürch, Garry P. Nolan, Derek R Holman, Sarah Streett, Brigid S. Boland, Sanjiv S. Gambhir, John T. Chang, Stephan Rogalla, William J. Sandborn, Sunil Bodapati, Salil S. Bhate, Jeff Chang, Graham L. Barlow, Aaron T. Mayer
Ulcerative colitis is a chronic-relapsing inflammatory disease of the large intestine with a complex, multifactorial pathogenesis. TNF inhibitors are widely used to suppress immune-mediated tissue damage in ulcerative colitis patients; however, thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e302fd9585da9af8eee495804476530f
https://doi.org/10.21203/rs.3.rs-167888/v1
https://doi.org/10.21203/rs.3.rs-167888/v1
Autor:
Gustavo Vazquez, Yury Goltsev, Salil S. Bhate, Garry P. Nolan, Sarah Black, Christian M. Schürch, John W. Hickey, Nikolay Samusik, Vishal G. Venkataraaman, Graham L. Barlow, Julia Kennedy-Darling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c82f37146ea42204614a733904b7710
https://doi.org/10.1002/eji.202048891/v2/response1
https://doi.org/10.1002/eji.202048891/v2/response1