Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Salil D. Desai"'
Autor:
Nicholas A. Meanwell, Ravi Kumar Trivedi, Tatyana Zvyaga, Richard Rampulla, Sarkunam Kandhasamy, Debarati Mazumder Tagore, Sureshbabu Vishwakrishnan, Arvind Mathur, Sunitha Puttaswamy, Abhijith Rao, Hua Fang, Sankar Sivaprasad, Susan Jenkins, Eric Mull, Kathy Mosure, Kaushik Ghosh, Barbara Zheng, Subba Reddy, Fiona McPhee, Chaoqun Chen, Bowsher Michael S, James Loy, Ying-Kai Wang, Amit Kumar, Ramkumar Rajamani, Kishore Rendunchintala, Paul Michael Scola, Gillis Eric P, Salil D. Desai, Li-Qiang Sun, Rushith Kumar Anumula, Nagalakshmi Pulicharla, Sheldon Hiebert, Venkata Rao Baratam, Paul Falk, Sarmistha Sinha, Stanley D'andrea
Publikováno v:
Journal of Medicinal Chemistry. 63:14740-14760
The discovery of a pan-genotypic hepatitis C virus (HCV) NS3/4A protease inhibitor based on a P1–P3 macrocyclic tripeptide motif is described. The all-carbon tether linking the P1–P3 subsites of 21...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fae1c3f9b157cd2f44f9613c2d3455
https://doi.org/10.1021/acs.jmedchem.0c01296
https://doi.org/10.1021/acs.jmedchem.0c01296
Autor:
Priyadeep Bhutani, John F. Kadow, Rambabu Arla, Sarmistha Sinha, Murugaiah A. M. Subbaiah, Susan Jenkins, Murali Subramanian, Salil D. Desai, Shweta Padmanabhan, Sandhya Mandlekar, Nicholas A. Meanwell, Lakshumanan Subramani, Srikanth Sridhar, Mark Krystal, Thangeswaran Ramar
Publikováno v:
European Journal of Medicinal Chemistry. 207:112749
We describe the design, synthesis and pharmacokinetic (PK) evaluation of a series of amino acid-based prodrugs of the HIV-1 protease inhibitor atazanavir (1) derivatized on the pharmacophoric secondary alcohol using a (carbonyl)oxyalkyl linker. Prodr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a522cc716bcd54b1c2ca6d46ed62051
https://doi.org/10.1016/j.ejmech.2020.112749
https://doi.org/10.1016/j.ejmech.2020.112749
Autor:
George Crull, Ipsit Kundu, Balvinder S. Vig, Varia Sailesh Amilal, Salil D. Desai, Hemant Bhutani, Narayana P. Swamy, Ravi P. Shah, Chiranjeevi Venkatesh, Sridhar Desikan, Sherif Badawy, Duohai Pan, Junshu Zhao
Publikováno v:
European Journal of Pharmaceutical Sciences. 152:105429
Poly (vinyl alcohol), PVA, a commonly used excipient to coat tablets, forms insoluble films in the presence of acids and thermal stress. This may lead to drug products failing to meet dissolution specifications over time. Studies were conducted to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7342bd600a26df6c2dc7dfdf4415bb3f
https://doi.org/10.1016/j.ejps.2020.105429
https://doi.org/10.1016/j.ejps.2020.105429
Autor:
Mathiazhagan Annadurai, Ramakanth Sarabu, Salil D. Desai, John F. Kadow, Nicholas A. Meanwell, Sarmistha Sinha, Susan Jenkins, Murali Subramanian, Rambabu Arla, Murugaiah A. M. Subbaiah, Thangeswaran Ramar, Shweta Padmanabhan, Priyadeep Bhutani, Mark Krystal, Chunfu Wang, Sandhya Mandlekar, Lakshumanan Subramani, Srikanth Sridhar
Publikováno v:
Journal of medicinal chemistry. 61(9)
HIV-1 protease inhibitors (PIs), which include atazanavir (ATV, 1), remain important medicines to treat HIV-1 infection. However, they are characterized by poor oral bioavailability and a need for boosting with a pharmacokinetic enhancer, which resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beaa0a404d060cc9d65f37630c6cc8b4
https://pubmed.ncbi.nlm.nih.gov/29693401
https://pubmed.ncbi.nlm.nih.gov/29693401
Autor:
Salil D. Desai, Lee E. Kirsch
Publikováno v:
International Journal of Chemical Kinetics. 47:471-488
The kinetics of formanilides hydrolysis were determined under first-order conditions in hydrochloric acid (0.01–8 M, 20–60°C) and in hydroxide solutions (0.01–3 M, 25 and 40°C). Under acidic conditions, second-order specific acid catalytic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cf8c419085ae1bad405dd6427338b05
https://doi.org/10.1002/kin.20925
https://doi.org/10.1002/kin.20925
Autor:
Zhixin Zong, Lee E. Kirsch, Salil D. Desai, Aditya Mohan Kaushal, Eric J. Munson, Raj Suryanarayanan, Dewey H. Barich, Kassibla Elodie Dempah
Publikováno v:
AAPS PharmSciTech. 14:19-28
Solid-state NMR spectroscopy (SSNMR), coupled with powder X-ray diffraction (PXRD), was used to identify the physical forms of gabapentin in samples prepared by recrystallization, spray drying, dehydration, and milling. Four different crystalline for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1956019abb180b09cbf4e36cda7852c3
https://doi.org/10.1208/s12249-012-9879-z
https://doi.org/10.1208/s12249-012-9879-z
Autor:
Lee E. Kirsch, Hong Shian Huang, Raj Suryanarayanan, Eric J. Munson, Salil D. Desai, Dewey H. Barich, Zhixin Zong, Aditya Mohan Kaushal
Publikováno v:
AAPS PharmSciTech. 12
Gabapentin is known to undergo intramolecular cyclization to form a lactam (gaba-L) with concomitant loss of water. Gabapentin was milled in a planetary mill for 15-60 min. Unmilled and milled gabapentin were stored at 50°C with relative humidity ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b2fd4f33c666c954b5f3c5621870ec
https://doi.org/10.1208/s12249-011-9652-8
https://doi.org/10.1208/s12249-011-9652-8
Autor:
Hong Shian Huang, Eric J. Munson, Lee E. Kirsch, Aditya Mohan Kaushal, Zhixin Zong, Salil D. Desai, Raj Suryanarayanan, Dewey H. Barich
Publikováno v:
AAPS PharmSciTech. 12:1465-1465
Erratum to: AAPS PharmSciTech DOI 10.1208/s12249-011-9652-8 ACKNOWLEDGEMENTS We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6160614137ac461f92a100de8eed4188
https://doi.org/10.1208/s12249-011-9692-0
https://doi.org/10.1208/s12249-011-9692-0