The Puzzle of Aspirin and Iron Deficiency: The Vital Missing Link of the Iron-Chelating Metabolites

Autor: George J. Kontoghiorghes

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 10, p 5150 (2024)

Acetylsalicylic acid or aspirin is the most commonly used drug in the world and is taken daily by millions of people. There is increasing evidence that chronic administration of low-dose aspirin of about 75–100 mg/day can cause iron deficiency anae

Externí odkaz: https://doaj.org/article/82fc1c6ec243486e9701fc79cf107dd5

Personalization of Aspirin Therapy Ex Vivo in Patients with Atherosclerosis Using Light Transmission Aggregometry

Autor: Reid C. Gallant, Philip Britz-McKibbin, Hamzah Khan, Muzammil H. Syed, Mohammad Qadura, Meera Shanmuganathan, Shubha Jain, Sherri Afxentiou, Margaret L. Rand, Mohammed Al-Omran, Zachary Kroezen, Abdelrahman Zamzam, Heyu Ni

Publikováno v: Diagnostics
Diagnostics, Vol 10, Iss 871, p 871 (2020)
Volume 10
Issue 11

Acetylsalicylic acid (ASA), also known as aspirin, appears to be ineffective in inhibiting platelet aggregation in 20&ndash
30% of patients. Light transmission aggregometry (LTA) is a gold standard platelet function assay. In this pilot study, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ab2fd795e231162b0c8c8c60ec4047
https://pubmed.ncbi.nlm.nih.gov/33114560

A Novel NF‐κB Inhibitor, Edasalonexent (CAT‐1004), in Development as a Disease‐Modifying Treatment for Patients With Duchenne Muscular Dystrophy: Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics in Adult Subjects

Autor: Michael R. Jirousek, Michael Zimmer, Elliot Offman, Joanne M. Donovan, Toni Grant

Publikováno v: Journal of Clinical Pharmacology

In Duchenne muscular dystrophy (DMD), NF‐κB is activated in skeletal muscle from infancy regardless of the underlying dystrophin mutation and drives inflammation and muscle degeneration while inhibiting muscle regeneration. Edasalonexent (CAT‐10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce430eb5c36dd129e0de446a149da4f
http://europepmc.org/articles/PMC5412838

Dietary protein source and butyrylated high-amylose maize starch included in a high-protein diet determines the urinary metabolome of rats

Autor: Mette Skou Hedemann, Tina Skau Nielsen, Zahra Sattari Najafabadi

Publikováno v: Sattari Najafabadi, Z, Nielsen, T S & Hedemann, M S 2019, ' Dietary protein source and butyrylated high-amylose maize starch included in a high-protein diet determines the urinary metabolome of rats ', International Journal of Food Sciences and Nutrition, vol. 70, no. 3, pp. 255-266 . https://doi.org/10.1080/09637486.2018.1499711

Intake of red and processed meat increases the risk of colorectal cancer (CRC), whereas dairy product consumption and the intake of dietary fibre are negatively associated with this risk. We investigated the effect of (i) low-protein diets with eithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb109b40b27bd65fdb5cd9c518e83b49

Determination of acetylsalicylic acid and its major metabolites in bovine urine using ultra performance liquid chromatography

Autor: Agustina Gómez-Hens, M.P. Aguilar-Caballos, M.L. Castillo-García

Publikováno v: Journal of Chromatography B. 985:85-90

A new method based on ultra high performance liquid chromatography (UPLC) with photometric and fluorometric detection for the determination of acetylsalicylic acid and its main metabolites, namely gentisic, salicylic and salicyluric acids, in bovine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22b3e5f0ed15ce05fc8ceea152adb64
https://doi.org/10.1016/j.jchromb.2015.01.026