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Synthetic viability genomic screening defines Sae2 function in DNA repair

Autor: Puddu, Fabio, Oelschlaegel, Tobias, Guerini, Ilaria, Geisler, Nicola J, Niu, Hengyao, Herzog, Mareike, Salguero, Israel, Ochoa-Montaño, Bernardo, Viré, Emmanuelle, Sung, Patrick, Adams, David J, Keane, Thomas M, Jackson, Stephen P

Publikováno v: The EMBO Journal

DNA double-strand break (DSB) repair by homologous recombination (HR) requires 3' single-stranded DNA (ssDNA) generation by 5' DNA-end resection. During meiosis, yeast Sae2 cooperates with the nuclease Mre11 to remove covalently bound Spo11 from DSB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5a49f22cbb0e3e8a61fcf11cc2501dde
http://europepmc.org/articles/PMC4474527

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Autor: Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M, Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Almeida, Estrella Guarino, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Thomas, Huw J W, Maher, Eamonn, Evans, Gareth, Lucassen, Anneke, Cummings, Carole, Stevens, Margaret, Walker, Lisa, Halliday, Dorothy, Armstrong, Ruth, Paterson, Joan, Hodgson, Shirley, Homfray, Tessa, Side, Lucy, Izatt, Louise, Donaldson, Alan, Tomkins, Susan, Morrison, Patrick, Goodman, Selina, Brewer, Carole, Henderson, Alex, Davidson, Rosemarie, Murday, Victoria, Cook, Jaqueline, Haites, Neva, Bishop, Timothy, Sheridan, Eamonn, Green, Andrew, Marks, Christopher, Carpenter, Sue, Broughton, Mary, Greenhalge, Lynn, Suri, Mohnish, Donnelly, Peter, Bell, John, Bentley, David, McVean, Gilean, Ratcliffe, Peter, Taylor, Jenny, Wilkie, Andrew, Broxholme, John, Buck, David, Cornall, Richard, Gregory, Lorna, Knight, Julian, Lunter, Gerton, Tomlinson, Ian, Kingsbury, Zoya, Grocock, Russell, Hatton, Edouard, Holmes, Christopher C, Hughes, Linda, Humburg, Peter, Kanapin, Alexander, Murray, Lisa, Rimmer, Andy, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J, Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Houlston, Richard S

Publikováno v: Nature Genetics; Vol 45
Nature genetics, vol 45, iss 2
Nature genetics
Nature Genetics

Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer (CRC) have no detectable germline mutations in the known cancer predisposition genes. Using whole-genome sequencing, supplemented by linkage and association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c2f35147b75323a3ef58abfb3296e3

Genome architecture and stability in the Saccharomyces cerevisiaeknockout collection

Autor: Puddu, Fabio, Herzog, Mareike, Selivanova, Alexandra, Wang, Siyue, Zhu, Jin, Klein-Lavi, Shir, Gordon, Molly, Meirman, Roi, Millan-Zambrano, Gonzalo, Ayestaran, Iñigo, Salguero, Israel, Sharan, Roded, Li, Rong, Kupiec, Martin, Jackson, Stephen P.

Publikováno v: Nature; September 2019, Vol. 573 Issue: 7774 p416-420, 5p

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