Sterile production of interferons in the thymus affects T cell repertoire selection.

Autor: Ashby KM; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Vobořil M; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Salgado OC; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Lee ST; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Martinez RJ; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., O'Connor CH; Research Informatics Solutions, Laboratory Medicine and Pathology Group, Minnesota Supercomputing Institute, Minneapolis, MN 55455, USA., Breed ER; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Xuan S; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Roll CR; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Bachigari S; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Heiland H; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Stetson DB; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.; Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 98109, USA., Kotenko SV; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.; Center for Cell Signaling, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.; Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA., Hogquist KA; Center for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Publikováno v: Science immunology [Sci Immunol] 2024 Jul 26; Vol. 9 (97), pp. eadp1139. Date of Electronic Publication: 2024 Jul 26.

Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells.

Autor: Sjaastad FV; Department of Urology, University of Minnesota, Minneapolis, MN.; Microbiology, Immunology, and Cancer Biology Ph.D. Program, University of Minnesota, Minneapolis, MN., Huggins MA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN., Lucas ED; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN., Skon-Hegg C; Department of Urology, University of Minnesota, Minneapolis, MN., Swanson W; Department of Urology, University of Minnesota, Minneapolis, MN., Martin MD; Department of Urology, University of Minnesota, Minneapolis, MN., Salgado OC; Microbiology, Immunology, and Cancer Biology Ph.D. Program, University of Minnesota, Minneapolis, MN.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN., Xu J; Department of Urology, University of Minnesota, Minneapolis, MN., Pierson M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN., Dileepan T; Center for Immunology, University of Minnesota, Minneapolis, MN.; Department of Microbiology & Immunology, University of Minnesota, Minneapolis, MN., Kucaba TA; Department of Urology, University of Minnesota, Minneapolis, MN., Hamilton SE; Microbiology, Immunology, and Cancer Biology Ph.D. Program, University of Minnesota, Minneapolis, MN.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.; Center for Immunology, University of Minnesota, Minneapolis, MN.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN; and., Griffith TS; Department of Urology, University of Minnesota, Minneapolis, MN.; Microbiology, Immunology, and Cancer Biology Ph.D. Program, University of Minnesota, Minneapolis, MN.; Center for Immunology, University of Minnesota, Minneapolis, MN.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN; and.; Minneapolis VA Health Care System, Minneapolis, MN.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Dec 01; Vol. 209 (11), pp. 2149-2159.

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.

Autor: Zhang Z; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States., Salgado OC; Center for Immunology, University of Minnesota, Minneapolis, MN, United States., Liu B; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States., Moazzami Z; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States.; Department of Food Science and Nutrition, University of Minnesota, Minneapolis, MN, United States., Hogquist KA; Center for Immunology, University of Minnesota, Minneapolis, MN, United States.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States., Farrar MA; Center for Immunology, University of Minnesota, Minneapolis, MN, United States.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States., Ruan HB; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, Minneapolis, MN, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Jul 08; Vol. 13, pp. 874863. Date of Electronic Publication: 2022 Jul 08 (Print Publication: 2022).

Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.

Autor: Zhao M; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Ren K; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; College of Medicine, Hunan Normal University, Changsha, Hunan, China., Xiong X; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Xin Y; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Zou Y; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Maynard JC; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA., Kim A; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Battist AP; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Koneripalli N; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Wang Y; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Chen Q; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Xin R; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Yang C; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Huang R; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Yu J; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Huang Z; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Zhang Z; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Wang H; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Wang D; College of Medicine, Hunan Normal University, Changsha, Hunan, China., Xiao Y; College of Medicine, Hunan Normal University, Changsha, Hunan, China., Salgado OC; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Jarjour NN; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Hogquist KA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Revelo XS; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Burlingame AL; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA., Gao X; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., von Moltke J; Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA., Lin Z; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China. Electronic address: linzy@nju.edu.cn., Ruan HB; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address: hruan@umn.edu.

Publikováno v: Immunity [Immunity] 2022 Apr 12; Vol. 55 (4), pp. 623-638.e5. Date of Electronic Publication: 2022 Apr 05.

Early childhood education is critical for T reg cells.

Autor: Salgado OC; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Hogquist KA; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. hogqu001@umn.edu.

Publikováno v: Nature immunology [Nat Immunol] 2019 Aug; Vol. 20 (8), pp. 952-954.