Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Saleha Omarjee"'
Autor:
One B. Dintwe, Lamar Ballweber Fleming, Valentin Voillet, John McNevin, Aaron Seese, Anneta Naidoo, Saleha Omarjee, Linda-Gail Bekker, James G. Kublin, Stephen C. De Rosa, Evan W. Newell, Andrew Fiore-Gartland, Erica Andersen-Nissen, M. Juliana McElrath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M.tb). In a companion phase 1b trial, HVTN 602/Aeras A-042, we cha
Externí odkaz:
https://doaj.org/article/2df45c22cd2240a5b3efbdb7bbd386ce
Autor:
Avi Kenny, Janine van Duijn, One Dintwe, Jack Heptinstall, Randy Burnham, Sheetal Sawant, Lu Zhang, Dieter Mielke, Sharon Khuzwayo, Faatima Laher Omar, Sherry Stanfield-Oakley, Taylor Keyes, Brooke Dunn, Derrick Goodman, Youyi Fong, David Benkeser, Rodger Zou, John Hural, Ollivier Hyrien, Michal Juraska, Alex Luedtke, Lars van der Laan, Elena E. Giorgi, Craig Magaret, Lindsay N. Carpp, Laura Pattacini, Tom van de Kerkhof, Bette Korber, Wouter Willems, Leigh H. Fisher, Hanneke Schuitemaker, Edith Swann, James G. Kublin, Maria G. Pau, Susan Buchbinder, Frank Tomaka, Steven Nijs, Ludo Lavreys, Huub C. Gelderblom, Lawrence Corey, Kathryn Mngadi, Glenda E. Gray, Erica Borducchi, Jenny Hendriks, Kelly E. Seaton, Susan Zolla-Pazner, Dan H. Barouch, Guido Ferrari, Stephen C. De Rosa, M Juliana McElrath, Erica Andersen-Nissen, Daniel J. Stieh, Georgia D. Tomaras, Peter B. Gilbert, Jon Allagappen, Jessica Andriesen, Alison Ayres, Saman Baral, Linda-Gail Bekker, Asiphe Besethi, Caroline Borremans, Esmee Braams, Caroline Brackett, William Brumskine, Roma Chilengi, Rachel Choi, Thozama Dubula, Jaiden Seongmi Dumas, Radhika Etikala, Zelda Euler, Sarah Everett, Nigel Garrett, Huub Gelderblom, Katherine Gill, Kevin Gillespie, Dimitri Goedhart, Erik Goosmann, Shannon Grant, Ellie Hands, Barton Haynes, Bronwill Herringer, Zaheer Hoosain, Mina Hosseinipour, Portia Hunidzarira, Julia Hutter, Mubiana Inambao, Craig Innes, William Kilembe, Philippus Kotze, Sheena Kotze, Fatima Laher, Imre Laszlo, Erica Lazarus, Hua-Xin Liao, Yong Lin, Helen Lu, Judith Lucas, Mookho Malahleha, Tara McNair, Peter Meerts, Zinhle Mgaga, Mahlodi Montlha, Boitumelo Mosito, Andrew Moultrie, Sarah Mudrak, Valérie Oriol-Mathieu, Marcella Sarzotti-Kelsoe, Matson Tso Mathebula, Mitch Matoga, Rachael McClennen, Pamela Mda, Vimla Naicker, Logashvari Naidoo, Cindy-Ann Okkers, Saleha Omarjee, Hella Pasmans, Tricia Philip, Abraham Pinter, Annah Pitsi, Ornelia Ramos, April Randhawa, Sanne Roels, Shamiska Rohith, Lucy Rutten, Jerald Sadoff, Gabriela Salinas, Yvonne Salzgeber, Lorenz Scheppler, Katharine Schwedhelm, Nicolette Schuller, Angelina Sharak, Carrie Sopher, Terence Tafatatha, Simbarashe G. Takuva, Chan Tang, An Vandebosch, Edna Viegas, Valentin Voillet, Frank Wegmann, Mo Weijtens, Stephany Wilcox, Anthony Williams, Chenchen Yu, Pei-Chun Yu, Olive Yuan, Xuehan Zhang
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105320- (2024)
Summary: Background: The HVTN 705 Imbokodo trial of 2636 people without HIV and assigned female sex at birth, conducted in southern Africa, evaluated a heterologous HIV-1 vaccine regimen: mosaic adenovirus 26-based vaccine (Ad26.Mos4.HIV) at Months 0
Externí odkaz:
https://doaj.org/article/f41b2bdf77344ddab5c165f46025f8a4
Autor:
Jaclyn K Mann, John P Barton, Andrew L Ferguson, Saleha Omarjee, Bruce D Walker, Arup Chakraborty, Thumbi Ndung'u
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 8, p e1003776 (2014)
Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape of HIV-1 proteins in orde
Externí odkaz:
https://doaj.org/article/40606355a56a42c4afdd328651f88042
Autor:
Denis R Chopera, Jaclyn K Mann, Philip Mwimanzi, Saleha Omarjee, Xiaomei T Kuang, Nonkululeko Ndabambi, Sarah Goodier, Eric Martin, Vivek Naranbhai, Salim Abdool Karim, Quarraisha Abdool Karim, Zabrina L Brumme, Thumbi Ndung'u, Carolyn Williamson, Mark A Brockman, CAPRISA 004 TRAPS Team
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71758 (2013)
Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections. To investigate this, we assessed the in vitro funct
Externí odkaz:
https://doaj.org/article/0beb17d4573a4c7a973a67afa52ef387
Autor:
Katlego Sojane, Martyn A. French, Saleha Omarjee, Bernadett I Gosnell, Keshni Hiramen, Thumbi Ndung'u, Christina C. Chang, Sharon R Lewin, Richard T. Kangethe, Mohamed-Yunus S Moosa
Publikováno v:
Open Forum Infectious Diseases
We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal
Autor:
Mahomed-Yunus S. Moosa, Julian H. Elliot, William H. Carr, Martyn A. French, Vivek Naranbhai, Andrew Lim, Christina C. Chang, Thumbi Ndung'u, Sharon R Lewin, Raveshni Durgiah, Saleha Omarjee
Publikováno v:
AIDS. 28:657-666
OBJECTIVE: The role of innate immunity in the pathogenesis of cryptococcal meningitis is unclear. We hypothesized that natural killer (NK) cell and monocyte responses show central nervous system (CNS) compartment-specific profiles, and are altered by
Autor:
Sharon R Lewin, Saleha Omarjee, Martyn A. French, Tim Spelman, Bernadett I Gosnell, Julian Elliott, Vivek Naranbhai, Christina C. Chang, Thumbi Ndung'u, Afton Dorasamy, Yacoob Coovadia, Mohamed-Yunus S Moosa
Publikováno v:
AIDS. 27:2089-2099
Objective HIV-infected patients with treated cryptococcal meningitis are at risk for further neurological deterioration after commencing combination antiretroviral therapy (cART), mostly because of cryptococcosis-associated immune reconstitution infl
Autor:
William H Carr, Bernadett I Gosnell, Martyn A. French, Saleha Omarjee, Christina C. Chang, Julian Elliott, Tim Spelman, Thumbi Ndung'u, Andrew Lim, Sharon R Lewin, Mohamed-Yunus S Moosa
Publikováno v:
The Journal of Infectious Diseases. 208:1604-1612
Background. Human immunodeficiency virus–infected patients with treated cryptococcal meningitis who start combination antiretroviral therapy (cART) are at risk of further neurological deterioration, in part caused by paradoxical cryptococcosis-asso
Autor:
Bruce D. Walker, Guinevere Q. Lee, P. Richard Harrigan, Zabrina L. Brumme, Conrad Muzoora, Mark A. Brockman, Chanson J. Brumme, Anh Q. Le, Rosemary M. McCloskey, Peter W. Hunt, Philip Mwimanzi, Bemuluyigza Baraki, Thumbi Ndung'u, Xiaomei T. Kuang, Jaclyn K. Mann, Helen Byakwaga, David R. Bangsberg, Philip J. R. Goulder, Saleha Omarjee, Ryan Danroth, Jeffrey N. Martin, Eric Martin
Publikováno v:
Retrovirology
Mann, Jaclyn K; Byakwaga, Helen; Kuang, Xiaomei T; Le, Anh Q; Brumme, Chanson J; Mwimanzi, Philip; et al.(2013). Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. Retrovirology, 10(1), 100. doi: http://dx.doi.org/10.1186/1742-4690-10-100. Retrieved from: http://www.escholarship.org/uc/item/1w64j6zj
Mann, Jaclyn K; Byakwaga, Helen; Kuang, Xiaomei T; Le, Anh Q; Brumme, Chanson J; Mwimanzi, Philip; et al.(2013). Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. Retrovirology, 10(1), 100. doi: http://dx.doi.org/10.1186/1742-4690-10-100. Retrieved from: http://www.escholarship.org/uc/item/1w64j6zj
Background The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison of Nef in vitro function has n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d8242bd78b3a1cf30e5638c630f145
https://ora.ox.ac.uk/objects/uuid:29f6c0e1-91a6-4f19-9371-47ca0ba3349b
https://ora.ox.ac.uk/objects/uuid:29f6c0e1-91a6-4f19-9371-47ca0ba3349b
Publikováno v:
Virology Journal
Background HIV-1 subtype C Nef sequences have a significantly lower ability overall to down-regulate CD4 and HLA-I than subtype B Nef sequences. Here we investigated whether Nef amino acids differing in frequency between HIV-1 subtypes B and C explai