Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Saleh M Ibrahim"'
Autor:
Shauni Doms, Hanna Fokt, Malte Christoph Rühlemann, Cecilia J Chung, Axel Kuenstner, Saleh M Ibrahim, Andre Franke, Leslie M Turner, John F Baines
Publikováno v:
eLife, Vol 11 (2022)
Determining the forces that shape diversity in host-associated bacterial communities is critical to understanding the evolution and maintenance of metaorganisms. To gain deeper understanding of the role of host genetics in shaping gut microbial trait
Externí odkaz:
https://doaj.org/article/a417e3f8a7ef41e8bd7a5e56be9977f9
Autor:
Dan Vodo, Ofer Sarig, Shamir Geller, Edna Ben-Asher, Tsviya Olender, Ron Bochner, Ilan Goldberg, Judith Nosgorodsky, Anna Alkelai, Pavel Tatarskyy, Alon Peled, Sharon Baum, Aviv Barzilai, Saleh M Ibrahim, Detlef Zillikens, Doron Lancet, Eli Sprecher
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006008 (2016)
Pemphigus vulgaris (PV) is a life-threatening autoimmune mucocutaneous blistering disease caused by disruption of intercellular adhesion due to auto-antibodies directed against epithelial components. Treatment is limited to immunosuppressive agents,
Externí odkaz:
https://doaj.org/article/a12a4bbe1ad744ff8c325b9792779ab8
Autor:
Julia Bischof, Saleh M Ibrahim
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161569 (2016)
Immunoglobulins, as well as T cell receptors, play a key role in adaptive immune responses because of their ability to recognize antigens. Recent advances in next generation sequencing improved also the quality and quantity of individual B cell recep
Externí odkaz:
https://doaj.org/article/94f8631e4f224bee8b4f892a4efe8919
Autor:
Anuradha Chauhan, Heike Weiss, Franziska Koch, Saleh M Ibrahim, Julio Vera, Olaf Wolkenhauer, Markus Tiedge
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0140858 (2015)
Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in glucose metabolism. Nutrient excess and mitochondrial imbalance are implicated in dysfunctional glucose metabolism with age. We used conplastic mouse strains with
Externí odkaz:
https://doaj.org/article/c8ab847ecc244fc1b3a128c5a007e668
Autor:
Julia Bischof, Sarah Müller, Luise Borufka, Farahnaz Asghari, Steffen Möller, Stephanie-Anna Holzhüter, Horst Nizze, Saleh M Ibrahim, Robert Jaster
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136298 (2015)
The mouse strain MRL/MpJ is prone to spontaneously develop autoimmune pancreatitis (AIP). To elucidate the genetic control towards the development of the phenotype and to characterize contributions of immunocompetent cell types, MRL/MpJ mice were int
Externí odkaz:
https://doaj.org/article/4e032575d43347e9a1c70ae7174f749e
Autor:
Florian Bär, Bandik Föh, René Pagel, Torsten Schröder, Heidi Schlichting, Misa Hirose, Susanne Lemcke, Antje Klinger, Peter König, Christian M Karsten, Jürgen Büning, Hendrik Lehnert, Klaus Fellermann, Saleh M Ibrahim, Christian Sina
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102347 (2014)
Enteroendocrine cells (EEC) produce neuropeptides, which are crucially involved in the maintenance of the intestinal barrier. Hence, EEC dysfunction is suggested to be involved in the complex pathophysiology of inflammatory bowel disease (IBD), which
Externí odkaz:
https://doaj.org/article/d91c14fc92564a9aab5180ab655ceb89
Autor:
Sarah Müller, Hannah Kaiser, Burkhard Krüger, Brit Fitzner, Falko Lange, Cristin N Bock, Horst Nizze, Saleh M Ibrahim, Georg Fuellen, Olaf Wolkenhauer, Robert Jaster
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94494 (2014)
Reactive oxygen species (ROS) have been implicated in the pathogenesis of acute pancreatitis (AP) for many years but experimental evidence is still limited. Uncoupling protein 2 (UCP2)-deficient mice are an accepted model of age-related oxidative str
Externí odkaz:
https://doaj.org/article/b77fc67812b84bc0a31087d63ec73987
Autor:
Sarah Müller, Burkhard Krüger, Falko Lange, Cristin N Bock, Horst Nizze, Änne Glass, Saleh M Ibrahim, Robert Jaster
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102266 (2014)
A polymorphism in the ATP synthase 8 (ATP8) gene of the murine mitochondrial genome, G-to-T transversion at position 7778, has been suggested to increase susceptibility to multiple autoimmune diseases, including autoimmune pancreatitis (AIP). The pol
Externí odkaz:
https://doaj.org/article/22dfae1a7a804c18a7d859ec3029c2b0
Autor:
Michael Olbrich, Adina-Malin Hartmann, Sven Künzel, Zouhair Aherrahrou, Paul Schilf, John F. Baines, Saleh M. Ibrahim, Misa Hirose
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107231- (2024)
We previously demonstrated that mice carrying natural mtDNA variants of the FVB/NJ strain (m.7778 G>T in the mt-Atp8 gene in mitochondrial complex V), namely C57BL/6 J-mtFVB/NJ (B6-mtFVB), exhibited (i) partial protection from experimental skin infla
Externí odkaz:
https://doaj.org/article/1a81fe206ac04aa69c9a82cb18c3724c
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75611 (2013)
Identifying the genetic basis of complex diseases, such as rheumatoid arthritis, remains a challenge that requires experimental models to reduce the genetic and environmental variability. Numerous loci for arthritis have been identified in induced an
Externí odkaz:
https://doaj.org/article/88bce52f021240e5b4ed68bb17920f41