Výsledky vyhledávání - "Saleh ALKarim"

Akademický článek

Pharmacophore-Model-Based Virtual-Screening Approaches Identified Novel Natural Molecular Candidates for Treating Human Neuroblastoma

Autor: F A Dain Md Opo, Saleh Alkarim, Ghadeer I. Alrefaei, Mohammad Habibur Rahman Molla, Nouf H. Alsubhi, Faisal Alzahrani, Foysal Ahammad

Publikováno v: Current Issues in Molecular Biology, Vol 44, Iss 10, Pp 4838-4858 (2022)

The mortality of cancer patients with neuroblastoma is increasing due to the limited availability of specific treatment options. Few drug candidates for combating neuroblastoma have been developed, and identifying novel therapeutic candidates against

Externí odkaz: https://doaj.org/article/12505fcdfe3c4f4a8a914f1554363dd5

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Akademický článek

Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies

Autor: F A Dain Md Opo, Mohammed Moulay, Ali Zari, Afnan Alqaderi, Saleh Alkarim, Talal Zari, Mohiuddin Ahmed Bhuiyan, Maged Mostafa Mahmoud, Fadwa Aljoud, Mohd Suhail, Sherif Edris, Wafaa S. Ramadan, Mohammad Amjad Kamal, Saïd Nemmiche, Foysal Ahammad

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Alterations to the EGFR (epidermal growth factor receptor) gene, which primarily occur in the axon 18–21 position, have been linked to a variety of cancers, including ovarian, breast, colon, and lung cancer. The use of TK inhibitors (gefitinib, erl

Externí odkaz: https://doaj.org/article/7cb9b879bdc148ee923908fd1c3ea0f6

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Akademický článek

Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders

Autor: Mohamed A. Zayed, Samar Sultan, Hashem O. Alsaab, Shimaa Mohammad Yousof, Ghadeer I. Alrefaei, Nouf H. Alsubhi, Saleh Alkarim, Kholoud S. Al Ghamdi, Sali Abubaker Bagabir, Ankit Jana, Badrah S. Alghamdi, Hazem M. Atta, Ghulam Md Ashraf

Publikováno v: Cells, Vol 11, Iss 21, p 3476 (2022)

Stem cells are a versatile source for cell therapy. Their use is particularly significant for the treatment of neurological disorders for which no definitive conventional medical treatment is available. Neurological disorders are of diverse etiology

Externí odkaz: https://doaj.org/article/fbe0816fa7ef44f6b149b3f7d4edba02

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Akademický článek

Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer’s Model

Autor: Wafaa S. Ramadan, Saleh Alkarim

Publikováno v: Cells, Vol 10, Iss 12, p 3511 (2021)

Patients suffering from Alzheimer’s disease (AD) are still increasing worldwide. The development of (AD) is related to oxidative stress and genetic factors. This study investigated the therapeutic effects of ellagic acid (EA) on the entorhinal cort

Externí odkaz: https://doaj.org/article/b8f073cc06c643ce97f5ec36548ecff1

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Akademický článek

from Inhibits Metastasis and Induces Apoptosis by Downregulating Gene in MCF7 Cell Line

Autor: Waqas Iqbal, Saleh Alkarim, Tahseen Kamal, Hani Choudhry, Jamal Sabir, Roop S. Bora, Kulvinder S. Saini

Publikováno v: Integrative Cancer Therapies, Vol 18 (2019)

Background: The role of alkaloids isolated from Rhazya stricta Decne (Apocynaceae family) (RS) in targeting genes involved in cancer and metastasis remains to be elucidated. Objective: Identify and characterize new compounds from RS, which inhibit ge

Externí odkaz: https://doaj.org/article/e9679c6298a54e3b9a3d0bdea5bf5630

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Akademický článek

Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats

Autor: Faisal A. Alzahrani, Mohammed A. El-Magd, Ahmed Abdelfattah-Hassan, Ayman A. Saleh, Islam M. Saadeldin, Eman S. El-Shetry, Abdelnaser A. Badawy, Saleh Alkarim

Publikováno v: Stem Cells International, Vol 2018 (2018)

Cross talk, mediated by exosomes, between normal stem cells and cancer stem cells (CSCs) in the tumor microenvironment has been given less attention so far. In addition, no publications are available in the literature that address the in vivo impact

Externí odkaz: https://doaj.org/article/48eec57c77f24be0b6f38273cc2c2cd4

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Akademický článek

Effects of low dose acrylamide on the rat reproductive organs structure, fertility and gene integrity

Autor: Saleh ALKarim, Sufyan ElAssouli, Soad Ali, Nasra Ayuob, Zaki ElAssouli

Publikováno v: Asian Pacific Journal of Reproduction, Vol 4, Iss 3, Pp 179-187 (2015)

Objectives: To assesses the effects of long term exposure to low dose of acrylamide (0.4 μg/g) in post-weaning Sprague–Dawley rats on the structure of the reproductive organ as well as DNA integrity. Methods: The histological changes in the male a

Externí odkaz: https://doaj.org/article/438f6e47dd364218a8fdbefa52a2c3cb

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