Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Saleet Jafri"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12886-12910 (2024)
Mutations in the ryanodine receptor (RyR2) gene have been linked to arrhythmia and possibly sudden cardiac death (SCD) during acute emotional stress, physical activities, or catecholamine perfusion. The most prevalent disorder is catecholaminergic po
Externí odkaz:
https://doaj.org/article/0ed7a3531f41424a83dd8f259c23d152
Autor:
Leena Nezamuldeen, Mohsin Saleet Jafri
Publikováno v:
Knowledge, Vol 4, Iss 3, Pp 422-443 (2024)
Variations in the genetic code for proteins are considered to confer traits and underlying disease. Identifying the functional consequences of these genetic variants is a challenging endeavor. There are online databases that contain variant informati
Externí odkaz:
https://doaj.org/article/105fa0078f434c65ac06c77a73200d80
Publikováno v:
BioMedInformatics, Vol 4, Iss 2, Pp 1396-1424 (2024)
Background: Ovarian cancer (OC) is the most lethal gynecological cancer in the United States. Among the different types of OC, serous ovarian cancer (SOC) stands out as the most prevalent. Transcriptomics techniques generate extensive gene expression
Externí odkaz:
https://doaj.org/article/240b1378309247688c56729c1a1cb1e8
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1371 (2024)
Previous studies have observed alterations in excitation–contraction (EC) coupling during end-stage heart failure that include action potential and calcium (Ca2+) transient prolongation and a reduction of the Ca2+ transient amplitude. Underlying th
Externí odkaz:
https://doaj.org/article/06a1d2fc0b2b40e39addabbf52512765
Autor:
Leena Nezamuldeen, Mohsin Saleet Jafri
Publikováno v:
Biology, Vol 13, Iss 8, p 606 (2024)
Cellular molecules interact with one another in a structured manner, defining a regulatory network topology that describes cellular mechanisms. Genetic mutations alter these networks’ pathways, generating complex disorders such as autism spectrum d
Externí odkaz:
https://doaj.org/article/dd503ad0ef7147b29e300570664aa837
Autor:
Raquel A. Adams, Zheng Liu, Chongere Hsieh, Michael Marko, W. Jonathan Lederer, M. Saleet Jafri, Carmen Mannella
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 7, Pp 6097-6115 (2023)
Mitochondria in mammalian cardiomyocytes display considerable structural heterogeneity, the significance of which is not currently understood. We use electron microscopic tomography to analyze a dataset of 68 mitochondrial subvolumes to look for corr
Externí odkaz:
https://doaj.org/article/51a0dfc17d1845cb83dab02cb067b59f
Autor:
Soukaina Amniouel, Mohsin Saleet Jafri
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Introduction: FOLFOX and FOLFIRI chemotherapy are considered standard first-line treatment options for colorectal cancer (CRC). However, the criteria for selecting the appropriate treatments have not been thoroughly analyzed.Methods: A newly develope
Externí odkaz:
https://doaj.org/article/df0824d53adf4054a1ffd7d1fbbf09b4
Autor:
Leena Nezamuldeen, Mohsin Saleet Jafri
Publikováno v:
Biology, Vol 12, Iss 10, p 1344 (2023)
Text mining methods are being developed to assimilate the volume of biomedical textual materials that are continually expanding. Understanding protein–protein interaction (PPI) deficits would assist in explaining the genesis of diseases. In this st
Externí odkaz:
https://doaj.org/article/8d8949b65db74993b28d9173553f0efc
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1259 (2023)
Calcium (Ca2+) sparks are the elementary events of excitation–contraction coupling, yet they are not explicitly represented in human ventricular myocyte models. A stochastic ventricular cardiomyocyte human model that adapts to intracellular Ca2+ ([
Externí odkaz:
https://doaj.org/article/ab0704475f0241f6996558e6c961f2bf
Publikováno v:
Current Research in Physiology, Vol 4, Iss , Pp 163-176 (2021)
Folding of the mitochondrial inner membrane (IM) into cristae greatly increases the ATP-generating surface area, SIM, per unit volume but also creates diffusional bottlenecks that could limit reaction rates inside mitochondria. This study explores po
Externí odkaz:
https://doaj.org/article/0d950773c2b040f1963c58c53b9e36bb