Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Saleemulla Mahammad"'
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1180-1191 (2019)
Abstract Chemotherapy‐induced peripheral neuropathy (PN) is a disorder damaging the peripheral nervous system (PNS) and represents one of the most common side effects of chemotherapy, negatively impacting the quality of life of patients to the exte
Externí odkaz:
https://doaj.org/article/3764edd4f1da44579dfe797072a729e3
Autor:
Saleemulla Mahammad, Jaline Broqueza, Brigitte L. Theriault, John Forbes, Christopher P. Leamon, John Valliant
Publikováno v:
Cancer Research. 83:5045-5045
Background: Neurotensin receptor 1 (NTSR1) is overexpressed in multiple cancer indications that include pancreatic, colorectal and prostate cancers, all of which have limited therapeutic treatment options and unmet medical need. Fusion is developing
Publikováno v:
Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1180-1191 (2019)
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1180-1191 (2019)
Chemotherapy-induced peripheral neuropathy (PN) is a disorder damaging the peripheral nervous system (PNS) and represents one of the most common side effects of chemotherapy, negatively impacting the quality of life of patients to the extent of withd
Autor:
Boris Grin, Saleemulla Mahammad, Tatjana Wedig, Megan M Cleland, Lester Tsai, Harald Herrmann, Robert D Goldman
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39065 (2012)
Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used as an anti-t
Externí odkaz:
https://doaj.org/article/64c94f5285614ee9a384b130be238e2a
Autor:
Saleemulla Mahammad, Mikkel H. Jensen, Ming Guo, Robert D. Goldman, Hilary Fabich, Jeffrey J. Fredberg, Jeffrey R. Moore, David A. Weitz, Allen J. Ehrlicher
Publikováno v:
Biophysical Journal. 105:1562-1568
The mechanical properties of a cell determine many aspects of its behavior, and these mechanics are largely determined by the cytoskeleton. Although the contribution of actin filaments and microtubules to the mechanics of cells has been investigated
Autor:
Alessandro Didonna, Saleemulla Mahammad, Boris Grin, Jean-Pierre Julien, Edward R. Kuczmarski, Pascale Bomont, S. N. Prasanna Murthy, Robert D. Goldman, Rodolphe Perrot, Eitan Israeli, Puneet Opal
Publikováno v:
Journal of Clinical Investigation. 123:1964-1975
Giant axonal neuropathy (GAN) is an early-onset neurological disorder caused by mutations in the GAN gene (encoding for gigaxonin), which is predicted to be an E3 ligase adaptor. In GAN, aggregates of intermediate filaments (IFs) represent the main p
Autor:
Robert D. Goldman, Puneet Opal, Vladimir I. Gelfand, Saleemulla Mahammad, Anne E. Goldman, Nikhil Jain, Edward R. Kuczmarski, Jason Lowery
Publikováno v:
Molecular Biology of the Cell, 27 (4)
Molecular Biology of the Cell
Molecular Biology of the Cell
Giant axonal neuropathy (GAN) is a rare disease caused by mutations in the GAN gene, which encodes gigaxonin, an E3 ligase adapter that targets intermediate filament (IF) proteins for degradation in numerous cell types, including neurons and fibrobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5150c255a1c2a01b38658f0e94208a6b
https://hdl.handle.net/20.500.11850/112325
https://hdl.handle.net/20.500.11850/112325
Autor:
Robert D. Goldman, S. N. Prasanna Murthy, Saleemulla Mahammad, Megan M. Cleland, Edward R. Kuczmarski
Publikováno v:
Journal of Structural Biology. 177:14-23
Although intermediate filaments are one of three major cytoskeletal systems of vertebrate cells, they remain the least understood with respect to their structure and function. This is due in part to the fact that they are encoded by a large gene fami
Autor:
Ingela Parmryd, Saleemulla Mahammad
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778:1251-1258
Methyl-beta-cyclodextrin (MBCD) is frequently used to acutely deplete cells of cholesterol. A widespread assumption is that MBCD preferentially targets cholesterol in lipid rafts and that sensitivity to MBCD is proof of lipid raft involvement in a ce
Autor:
Saleemulla, Mahammad, Ingela, Parmryd
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1232
Cholesterol is an essential component of mammalian cells. It is the major lipid constituent of the plasma membrane and is also abundant in most other organelle membranes. In the plasma membrane cholesterol plays critical physical roles in the mainten