Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Saleem Yousuf Bhat"'
Publikováno v:
ACS Omega, Vol 6, Iss 29, Pp 19076-19085 (2021)
Externí odkaz:
https://doaj.org/article/078ae7f6831c483790e562dcca8b1e7e
Autor:
Srikanth Battu, Sumbul Afroz, Jeevan Giddaluru, Saima Naz, Weishan Huang, Saratchandra Singh Khumukcham, Rafiq Ahmad Khan, Saleem Yousuf Bhat, Insaf Ahmed Qureshi, Bramanandam Manavathi, Aleem Ahmed Khan, Avery August, Seyed Ehtesham Hasnain, Nooruddin Khan
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2005317 (2018)
Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halo
Externí odkaz:
https://doaj.org/article/4475e910e3734fa4a2d29e1cbe9801cb
Publikováno v:
Chemical Biology & Drug Design. 97:315-324
Methionine aminopeptidase 1 (MetAP1) is a target for drug discovery against many adversaries and a potential antileishmanial target for its role in N-terminal methionine processing. As an effort towards new inhibitor discovery against methionine amin
Autor:
Insaf A. Qureshi, Saleem Yousuf Bhat
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 29, Pp 19076-19085 (2021)
ACS Omega, Vol 6, Iss 29, Pp 19076-19085 (2021)
A leucine aminopeptidase primarily hydrolyzes amino acid leucine from the N-terminus end of proteins and is involved in free amino acid regulation, which makes it a potential therapeutic target against neglected tropical diseases including leishmania
Publikováno v:
International Journal of Biological Macromolecules. 115:940-954
Methionine aminopeptidase 2 (MAP2) is a principal regulator of apoptosis for Leishmania donovani and a potential candidate for the design and synthesis of novel antileishmanials. The LdMAP2 gene was cloned in pET28a(+)-SUMO vector, expressed in E. co
Autor:
Insaf A. Qureshi, Saleem Yousuf Bhat
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1864:129465
Background M20 aminopeptidases, such as Peptidase T (PepT), are implicated in the hydrolysis of oligopeptides during the terminal stages of protein degradation pathway to maintain turnover. Therefore, specific inhibition of PepT bores well for the de
Autor:
Mohammed Arifuddin, Saleem Yousuf Bhat, Angapelly Srinivas, Peddapaka Jagruthi, Insaf A. Qureshi
Publikováno v:
European Journal of Medicinal Chemistry. 186:111860
Methionine aminopeptidase 1 of Leishmania donovani (LdMetAP1) is a novel antileishmanial target for its role in vital N-terminal methionine processing. After LdMetAP1 expression and purification, we employed a series of biochemical assays to determin
Autor:
Insaf A. Qureshi, Aleem Ahmed Khan, Sumbul Afroz, Saratchandra Singh Khumukcham, Seyed E. Hasnain, Bramanandam Manavathi, Saleem Yousuf Bhat, Jeevan Giddaluru, Rafiq Ahmad Khan, Saima Naz, Nooruddin Khan, Srikanth Battu, Weishan Huang, Avery August
Publikováno v:
PLoS Biology
PLoS Biology, Vol 16, Iss 4, p e2005317 (2018)
PLoS Biology, Vol 16, Iss 4, p e2005317 (2018)
Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halo