Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Saleela A"'
Autor:
Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 4, Pp 1-19 (2019)
Abstract Oncogenic KRAS mutations are major drivers of lung adenocarcinoma (LAC), yet the direct therapeutic targeting of KRAS has been problematic. Here, we reveal an obligate requirement by oncogenic KRAS for the ADAM17 protease in LAC. In genetica
Externí odkaz:
https://doaj.org/article/651450bcc02047a78683c22380e772e6
Autor:
Brendan J. Jenkins, Tracy Putoczki, Cem Gabay, Masanobu Oshima, Matthias Ernst, Meri Najdovska, Hazel Tye, Ka Yee Fung, Hiroko Oshima, Adele Preaudet, Charlotte Girard, Thaleia Livis, Jesse Balic, Saleela M. Ruwanpura, Liang Yu, Alison F. Browning, Alison West, Paul Nguyen, Virginie Deswaerte
The content of this file containing Supplementary Figures (and a Supplementary Table) provides additional (and essential) data supporting our conclusions that the ASC inflammasome/caspase-1/IL-18 axis promotes gastric tumorigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f645c44a30e642b4a7137f788bfaeca
https://doi.org/10.1158/0008-5472.22412141.v1
https://doi.org/10.1158/0008-5472.22412141.v1
Autor:
Brendan J. Jenkins, Tracy Putoczki, Cem Gabay, Masanobu Oshima, Matthias Ernst, Meri Najdovska, Hazel Tye, Ka Yee Fung, Hiroko Oshima, Adele Preaudet, Charlotte Girard, Thaleia Livis, Jesse Balic, Saleela M. Ruwanpura, Liang Yu, Alison F. Browning, Alison West, Paul Nguyen, Virginie Deswaerte
Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801933ca152887dfe221ae1ba60ea2a9
https://doi.org/10.1158/0008-5472.c.6508370.v1
https://doi.org/10.1158/0008-5472.c.6508370.v1
Autor:
Brendan J. Jenkins, Saleela Ruwanpura, Stefan Rose-John, Walter Ferlin, Prudence A. Russell, Alistair Miller, Sultan Alhayyani, Louise McLeod, Gavin D. Brooks
Legends for supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c973d9643f4d6a309048c7a49f04339
https://doi.org/10.1158/0008-5472.22410263.v1
https://doi.org/10.1158/0008-5472.22410263.v1
Autor:
Brendan J. Jenkins, Saleela Ruwanpura, Stefan Rose-John, Walter Ferlin, Prudence A. Russell, Alistair Miller, Sultan Alhayyani, Louise McLeod, Gavin D. Brooks
Table S1: Clinicopathological features of LAC patients and control LAC-free individuals. Table S2: Primers used in qPCR assays. Figure S1: Augmented Kras-induced lung adenocarcinoma in gp130F/F mice is not associated with enhanced inflammation. Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265a9a2e1035e7a94c231a0974d38980
https://doi.org/10.1158/0008-5472.22410260.v1
https://doi.org/10.1158/0008-5472.22410260.v1
Autor:
Brendan J. Jenkins, Saleela Ruwanpura, Stefan Rose-John, Walter Ferlin, Prudence A. Russell, Alistair Miller, Sultan Alhayyani, Louise McLeod, Gavin D. Brooks
Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130F/F (Il6st) knock-in mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8351354c25fcc58b80c98b467c8e2f6a
https://doi.org/10.1158/0008-5472.c.6507947.v1
https://doi.org/10.1158/0008-5472.c.6507947.v1
Autor:
Saleela M. Ruwanpura, Louise McLeod, Lovisa F. Dousha, Huei J. Seow, Alison C. West, Alice J. West, Teresa Weng, Mohammad Alanazi, Martin MacDonald, Paul T. King, Philip G. Bardin, Cem Gabay, Dennis M. Klinman, Steven Bozinovski, Ross Vlahos, Gary P. Anderson, Stefan Rose-John, Mohamed I. Saad, Brendan J. Jenkins
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Pulmonary emphysema is associated with dysregulated innate immune responses that promote chronic pulmonary inflammation and alveolar apoptosis, culminating in lung destruction. However, the molecular regulators of innate immunity that promote emphyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd23fd28aac440ecf2103665234cc4be
https://pubmed.ncbi.nlm.nih.gov/36037355
https://pubmed.ncbi.nlm.nih.gov/36037355
Autor:
Zdenka Prodanovic, Saleela Ruwanpura, Brendan J. Jenkins, Beena Kumar, Liang Yu, Steven Bozinovski, Christopher Hodges, Sultan Alhayyani, Louise McLeod, Alison C. West, Jesse J. Balic, Mohamed I. Saad, Julian A. Smith
Publikováno v:
Oncogene. 41:809-823
The oncogenic potential of the latent transcription factor signal transducer and activator of transcription (STAT)3 in many human cancers, including lung cancer, has been largely attributed to its nuclear activity as a tyrosine-phosphorylated (pY705
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d2300730897837b0813be8df1f3379
https://doi.org/10.1038/s41388-021-02134-4
https://doi.org/10.1038/s41388-021-02134-4
Autor:
null A. P. Dineshbabu, null P. T. Sarada, null G. Maheswarudu, S. Lakshmi Pillai, Gyanranjan Dash, Indira Divipala, Rajan Kumar, Rekha Devi Chakraborty, null M. Rajkumar, null J. Jayasankar, null R. Ratheeshkumar, null K. N. Saleela, Josileen Jose
Publikováno v:
Indian Journal of Fisheries. 69
Population dynamics of the brown shrimp Metapenaeus monoceros (Fabricius, 1798) was studied along the Indian coast using catch and effort data of trawlers from 8 States and 2 Union Territories for the period 2007-2015. Classical length-based stock as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8217d66f9109d8b719d97bf657f7fa
https://doi.org/10.21077/ijf.2022.69.4.118663-01
https://doi.org/10.21077/ijf.2022.69.4.118663-01
Publikováno v:
EnvironmentAsia, Vol 7, Iss 1, Pp 13-18 (2014)
Medicine contains active pharmaceutical ingredients which may do harm to the environment when dispersed into the environment. Once people have leftover medicines, if they discard them incorrectly, these medicines will contaminate the environment. Thi
Externí odkaz:
https://doaj.org/article/5ef361bbc22644fda833e53b108b859c