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H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade Gliomas

Autor: Garcia-Fabiani, Maria B., Haase, Santiago, Banerjee, Kaushik, McClellan, Brandon, Zhu, Ziwen, Mujeeb, Anzar, Li, Yingxiang, Yu, Jin, Kadiyala, Padma, Taher, Ayman, Núñez, Felipe J., Alghamri, Mahmoud S., Comba, Andrea, Mendez, Flor M., Nicola Candia, Alejandro J., Salazar, Brittany, Koschmann, Carl, Nunez, Fernando M., Edwards, Marta, Qin, Tingting, Sartor, Maureen A., Lowenstein, Pedro R., Castro, Maria G.

Publikováno v: bioRxiv

Pediatric high-grade gliomas (pHGGs) are diffuse and highly aggressive CNS tumors which remain incurable, with a 5-year overall survival of less than 20%. Within glioma, mutations in the genes encoding the histones H3.1 and H3.3 have been discovered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2136808225639b50b3a0f39ccc38ef67
https://europepmc.org/articles/PMC10312611/

H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade Gliomas.

Autor: Garcia-Fabiani MB; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Current address: Leloir Institute Foundation, Buenos Aires, Argentina., Haase S; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Banerjee K; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., McClellan B; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Zhu Z; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mujeeb A; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Li Y; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Yu J; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Current address: Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Kadiyala P; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Taher A; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Núñez FJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Alghamri MS; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Comba A; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mendez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Nicola Candia AJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Salazar B; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Cancer Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA., Koschmann C; Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA., Nunez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Edwards M; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Qin T; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Sartor MA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Lowenstein PR; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Bioengineering, University of Michigan, Ann Arbor, MI 48109, USA., Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 13. Date of Electronic Publication: 2023 Jun 13.