NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and associated with stroke.

Autor: Rodriguez-Flores JL; Regeneron Genetics Center, Tarrytown, NY, USA., Khalid S; Columbia University, New York, NY, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Parikshak N; Regeneron Genetics Center, Tarrytown, NY, USA., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Ye B; Regeneron Genetics Center, Tarrytown, NY, USA., Kapoor M; Regeneron Genetics Center, Tarrytown, NY, USA., Backman J; Regeneron Genetics Center, Tarrytown, NY, USA., Sepehrband F; Regeneron Genetics Center, Tarrytown, NY, USA., Gioia SAD; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Gelfman S; Regeneron Genetics Center, Tarrytown, NY, USA., De T; Regeneron Genetics Center, Tarrytown, NY, USA., Banerjee N; Regeneron Genetics Center, Tarrytown, NY, USA., Sharma D; Regeneron Genetics Center, Tarrytown, NY, USA., Martinez H; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Castaneda S; Rye Country Day School, Rye, NY, USA., D'Ambrosio D; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Zhang XA; Regeneron Genetics Center, Tarrytown, NY, USA., Xun P; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Tsai E; University of California at Los Angeles, Los Angeles, CA, USA., Tsai IC; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Khan MZ; Center for Non-Communicable Diseases, Karachi, Pakistan., Jahanzaib M; Center for Non-Communicable Diseases, Karachi, Pakistan., Mian MR; Center for Non-Communicable Diseases, Karachi, Pakistan., Liaqat MB; Center for Non-Communicable Diseases, Karachi, Pakistan., Mahmood K; Dow University of Health Sciences and Civil Hospital, Karachi, Pakistan., Salam TU; Lahore General Hospital, Lahore, Pakistan., Hussain M; Lahore General Hospital, Lahore, Pakistan., Iqbal J; Department of Neurology, Allied Hospital, Faisalabad, Pakistan., Aslam F; Department of Neurology, Aziz Fatima Hospital, Faisalabad, Pakistan., Cantor MN; Regeneron Genetics Center, Tarrytown, NY, USA., Tzoneva G; Regeneron Genetics Center, Tarrytown, NY, USA., Overton J; Regeneron Genetics Center, Tarrytown, NY, USA., Marchini J; Regeneron Genetics Center, Tarrytown, NY, USA., Reid JG; Regeneron Genetics Center, Tarrytown, NY, USA., Baras A; Regeneron Genetics Center, Tarrytown, NY, USA., Verweij N; Regeneron Genetics Center, Tarrytown, NY, USA., Lotta LA; Regeneron Genetics Center, Tarrytown, NY, USA., Coppola G; Regeneron Genetics Center, Tarrytown, NY, USA., Karalis K; Regeneron Genetics Center, Tarrytown, NY, USA., Economides A; Regeneron Genetics Center, Tarrytown, NY, USA., Fazio S; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Liedtke W; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Kamal A; Section of Neurology, Department of Medicine, Aga Khan University, Karachi, Pakistan., Frossard P; Center for Non-Communicable Diseases, Karachi, Pakistan., Coleman T; Regeneron Genetics Center, Tarrytown, NY, USA., Shuldiner AR; Regeneron Genetics Center, Tarrytown, NY, USA. alan.shuldiner@regeneron.com., Saleheen D; Columbia University, New York, NY, USA. danish.saleheen@cncdpk.com.; Center for Non-Communicable Diseases, Karachi, Pakistan. danish.saleheen@cncdpk.com.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 13; Vol. 15 (1), pp. 8029. Date of Electronic Publication: 2024 Sep 13.