Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Salam A Assi"'
Autor:
M S Vijayabaskar, Debbie K Goode, Nadine Obier, Monika Lichtinger, Amber M L Emmett, Fatin N Zainul Abidin, Nisar Shar, Rebecca Hannah, Salam A Assi, Michael Lie-A-Ling, Berthold Gottgens, Georges Lacaud, Valerie Kouskoff, Constanze Bonifer, David R Westhead
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007337 (2019)
Gene expression governs cell fate, and is regulated via a complex interplay of transcription factors and molecules that change chromatin structure. Advances in sequencing-based assays have enabled investigation of these processes genome-wide, leading
Externí odkaz:
https://doaj.org/article/ce48b7160bf8439990c2092f2e79e3da
Publikováno v:
Cancer Informatics, Vol 18 (2019)
Acute myeloid leukemia (AML) is a highly heterogeneous cancer associated with different patterns of gene expression determined by the nature of their DNA mutations. These mutations mostly act to deregulate gene expression by various mechanisms at the
Externí odkaz:
https://doaj.org/article/289e93d467f44a1c9a23bcf641f40e91
Autor:
Sophie G. Kellaway, Sandeep Potluri, Peter Keane, Helen J. Blair, Luke Ames, Alice Worker, Paulynn S. Chin, Anetta Ptasinska, Polina K. Derevyanko, Assunta Adamo, Daniel J. L. Coleman, Naeem Khan, Salam A. Assi, Anja Krippner-Heidenreich, Manoj Raghavan, Peter N. Cockerill, Olaf Heidenreich, Constanze Bonifer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating
Externí odkaz:
https://doaj.org/article/d6aa9401fa5141ad9c390f2a12d3bb12
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12352 (2010)
It is well established that only a portion of residues that mediate protein-protein interactions (PPIs), the so-called hot spot, contributes the most to the total binding energy, and thus its identification is an important and relevant question that
Externí odkaz:
https://doaj.org/article/8e9d28e371fc430d85d59863c35dbdbd
Autor:
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam A. Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Fischer, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interaction
Externí odkaz:
https://doaj.org/article/89617bbfc2d9437a8c22b2474e5ec08c
Autor:
Daniel J.L. Coleman, Peter Keane, Rosario Luque-Martin, Paulynn S. Chin, Helen Blair, Luke Ames, Sophie G. Kellaway, James Griffin, Elizabeth Holmes, Sandeep Potluri, Salam A. Assi, John Bushweller, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113568- (2023)
Summary: Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations. Previously, we showed that each mutational subtype develops its specific gene regulatory network (GRN) with transcription factors interacting within multi
Externí odkaz:
https://doaj.org/article/72be4bba0590424496380b929459cff5
Autor:
Justin Loke, Paulynn Suyin Chin, Peter Keane, Anna Pickin, Salam A. Assi, Anetta Ptasinska, Maria Rosaria Imperato, Peter N. Cockerill, Constanze Bonifer
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 271-284 (2018)
Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease caused by recurrent mutations in the transcription regulatory machinery, resulting in abnormal growth and a block in differentiation. One type of recurrent mutations affects RUNX1, whi
Externí odkaz:
https://doaj.org/article/53fe5de30ee84f8cad9a638d6d9e6fb5
Autor:
Paul Milne, Helen J. Blair, Cornelia Eckert, Zoya Kingsbury, Matthew Collin, Anetta Ptasinska, Alex Elder, Roderick Skinner, Janine Stutterheim, Jennifer Becq, Elena Zerkalenkova, Constanze Bonifer, Denis M. Schewe, Peter N. Cockerill, N Martinez-Soria, Oskar A. Haas, Peter Carey, Katarzyna Szoltysek, Deepali Pal, Hesta McNeill, Claus Meyer, Maria Rosaria Imperato, James C. Mulloy, Mark Wunderlich, Catherine Cargo, Paul Evans, Sarah E. Fordham, Shan Lin, Pierre Cauchy, Y Shi, Simon Bailey, Salam A. Assi, Rolf Marschalek, Josef Vormoor, Olaf Heidenreich, A Komkov, Michael J. Thirman, Simon Bomken, Ricky Tirtakusuma, Sirintra Nakjang, Fotini Vogiatzi, James M. Allan, Lisa J. Russell, Jayne Y. Hehir-Kwa, Muzlifah Haniffa, Yulia Olshanskaya, Vasily V. Grinev, Christine J. Harrison, Venetia Bigley, Daniel Williamson, Alex Smith, Natalia Miakova
Publikováno v:
Blood. 140:1875-1890
The fusion gene MLL-AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. However, relapse can be associated with a switch from acute lymphoblastic to acute myeloid leukaemia. Here we show that these myeloid relapses share oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc1d67bb85567d28d48decb91162f8
https://doi.org/10.1182/blood.2021015036
https://doi.org/10.1182/blood.2021015036
Autor:
Sophie G Kellaway, Sandeep Potluri, Peter Keane, Helen J. Blair, Paulynn S Chin, Anetta Ptasinska, Alice Worker, Luke Ames, Assunta Adamo, Daniel JL Coleman, Naeem Khan, Salam A. Assi, Anja Krippner-Heidenreich, Manoj Raghavan, Peter N Cockerill, Olaf Heidenreich, Constanze Bonifer
SummaryAcute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8fad45ca94531921bd18c15689121f
https://doi.org/10.1101/2023.03.10.532081
https://doi.org/10.1101/2023.03.10.532081
Autor:
Shanna M Hogeling, Roos Houtsma, Nisha K Van Der Meer, Salam A. Assi, Paulynn Chin, Alan Cunningham, Peter Keane, Dominique Sternadt Alexandre Ramos, Lieve Oudejans, Gerwin A. Huls, Constance Bonifer, Jan Jacob Schuringa
Publikováno v:
Blood. 140:5844-5845
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5961d7a0cb0e0de551cf206ba1169dfe
https://doi.org/10.1182/blood-2022-159999
https://doi.org/10.1182/blood-2022-159999