Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Salahuddin Mirza"'
Autor:
Vittoria Lopez, H. J. Maximilian Schuh, Salahuddin Mirza, Victoria J. Vaaßen, Michael S. Schmidt, Katharina Sylvester, Riham M. Idris, Christian Renn, Laura Schäkel, Julie Pelletier, Jean Sévigny, Annamaria Naggi, Björn Scheffler, Sang-Yong Lee, Gerd Bendas, Christa E. Müller
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHeparins, naturally occurring glycosaminoglycans, are widely used for thrombosis prevention. Upon application as anticoagulants in cancer patients, heparins were found to possess additional antitumor activities. Ectonucleotidases have rec
Externí odkaz:
https://doaj.org/article/a4e6c471d88140e28ff18ae97091a960
Autor:
Julie Pelletier, Jean Sévigny, Laura Schäkel, Salahuddin Mirza, Riekje Winzer, Vittoria Lopez, Riham Idris, Haneen Al-Hroub, Eva Tolosa, Christa E Müller
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background An important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A2A and A2B receptors on immune cells constituting one of the stronge
Externí odkaz:
https://doaj.org/article/8abf22ac4a1d4fadacc1d985d35a7a52
Autor:
Laura Schäkel, Constanze C. Schmies, Riham M. Idris, Xihuan Luo, Sang-Yong Lee, Vittoria Lopez, Salahuddin Mirza, The Hung Vu, Julie Pelletier, Jean Sévigny, Vigneshwaran Namasivayam, Christa E. Müller
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential as novel drugs for the (immuno)therapy of cancer. They increase the extracellular concentration of immunostimulatory ATP and reduce the formation of AMP, which can
Externí odkaz:
https://doaj.org/article/903114e2b7ec421aacb756b26bca55e7
Autor:
Vittoria Lopez, Laura Schäkel, H. J. Maximilian Schuh, Michael S. Schmidt, Salahuddin Mirza, Christian Renn, Julie Pelletier, Sang-Yong Lee, Jean Sévigny, Susanne Alban, Gerd Bendas, Christa E. Müller
Publikováno v:
Marine Drugs, Vol 19, Iss 2, p 51 (2021)
Extracellular ATP mediates proinflammatory and antiproliferative effects via activation of P2 nucleotide receptors. In contrast, its metabolite, the nucleoside adenosine, is strongly immunosuppressive and enhances tumor proliferation and metastasis.
Externí odkaz:
https://doaj.org/article/ad33f021591e4b8c9d89846b9ce9de57
Autor:
Chunyang Bi, Laura Schäkel, Salahuddin Mirza, Katharina Sylvester, Julie Pelletier, Sang-Yong Lee, Thanigaimalai Pillaiyar, Jean Sévigny, Christa E. Müller
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29858e01013eb6ef87beea78d536f9fc
https://doi.org/10.2139/ssrn.4329378
https://doi.org/10.2139/ssrn.4329378
Autor:
Hai-Jun Zhang, Michał Ociepa, Molhm Nassir, Bin Zheng, Sarah Lewicki, Veronica Salmaso, Helay Babury, Jessica Nagel, Salahuddin Mirza, Beatriz Bueschbell, Haneen Al-Hroub, Olga Perzanowska, Ziqing Lin, Michael Schmidt, Martin Eastgate, Kenneth Jacobson, Christa Müller, Joanna Kowalska, Jacek Jemielity, Phil Baran
Nucleoside diphosphates and triphosphates impact nearly every aspect of biochemistry, however, the use of such compounds as tools or medicinal leads for nucleotide-dependent enzymes and receptors is hampered due to rapid metabolism. Meanwhile, a succ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b6b6f9d1220cfc943dc9c6ea3a7f76
https://doi.org/10.26434/chemrxiv-2022-r4hpx
https://doi.org/10.26434/chemrxiv-2022-r4hpx
Autor:
Nina Geiger, Dominik Thimm, Thanigaimalai Pillaiyar, Robin Gedschold, Laura Schäkel, Michael Gütschow, Christa E. Müller, Ghazl Al Hamwi, Maria Zyulina, Vittoria Lopez, Christin Vielmuth, Katharina Sylvester, Miriam Diett, Lan Phuong Vu, Vigneshwaran Namasivayam, Julian Breidenbach, Anke C. Schiedel, Jochen Bodem, Salahuddin Mirza, Carina Lemke
Publikováno v:
Angewandte Chemie. 133:10515-10521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff9821b9fd888dcc360c6ff44e464c3
https://doi.org/10.1002/ange.202016961
https://doi.org/10.1002/ange.202016961
Autor:
Tim Keuler, Vigneshwaran Namasivayam, Michael Gütschow, Christa E. Müller, Sang-Yong Lee, Thanigaimalai Pillaiyar, Katharina Sylvester, Laura Schäkel, Julie Pelletier, Jean Sévigny, Markus Pietsch, Salahuddin Mirza
Publikováno v:
Archiv der PharmazieREFERENCES. 354(12)
The antithrombotic prodrugs ticlopidine and clopidogrel are thienotetrahydro-pyridine derivatives that are metabolized in the liver to produce thiols that irreversibly block adenosine diphosphate (ADP)-activated P2Y12 receptors on thrombocytes. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a324c29e0e7ca7d6821d62a3502f1b
https://pubmed.ncbi.nlm.nih.gov/34697820
https://pubmed.ncbi.nlm.nih.gov/34697820
Autor:
Bilha Fischer, Christian Renn, Salahuddin Mirza, Jean Sévigny, Sang-Yong Lee, Christa E. Müller, Uri Arad, Muhammad Rafehi, Julie Pelletier, Isaac Yaw Attah, Molhm Nassir, Herbert Zimmermann
Publikováno v:
Organic & Biomolecular Chemistry. 17:9913-9923
Nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) inhibitors have been suggested as a potential treatment for calcium pyrophosphate dihydrate (CPPD) deposition disease. Here, we targeted the development of improved NPP1 inhibitors based on acycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7edb1359d333ea69722971e8fbc97909
https://doi.org/10.1039/c9ob02199j
https://doi.org/10.1039/c9ob02199j
Autor:
Laura Schäkel, Salahuddin Mirza, Riekje Winzer, Vittoria Lopez, Riham Idris, Haneen Al-Hroub, Julie Pelletier, Jean Sévigny, Eva Tolosa, Christa E Müller
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e004660
BackgroundAn important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A2A and A2B receptors on immune cells constituting one of the stronges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2048c73c4e6125db35a0fd9ff31ccd9c
https://doi.org/10.1136/jitc-2022-004660
https://doi.org/10.1136/jitc-2022-004660