Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis.

Autor: Nardone V; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Giannicola R; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy., Giannarelli D; Biostatistical Unit, National Cancer Institute 'Regina Elena', IRCCS, 00161 Rome, Italy., Saladino RE; Tissue typing Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy., Azzarello D; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy., Romeo C; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy., Bianco G; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy., Rizzo MR; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Di Meo I; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Nesci A; Unit of Pharmacy, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy., Pastina P; Section of Radiation Oncology, Medical School, University of Siena, 53100 Siena, Italy., Falzea AC; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy., Caracciolo D; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy., Reginelli A; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Caraglia M; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.; BiogemScarl, Institute of Genetic Research, Precision and Molecular Oncology Laboratory, Ariano Irpino, 83031 Avellino, Italy., Luce A; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Mutti L; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA., Giordano A; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.; Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy., Cappabianca S; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Pirtoli L; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA., Barbieri V; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy., Tassone P; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy., Tagliaferri P; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy., Correale P; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.

Publikováno v: Life (Basel, Switzerland) [Life (Basel)] 2021 Nov 15; Vol. 11 (11). Date of Electronic Publication: 2021 Nov 15.

Is There Already a Need of Reckoning on Cancer Immunotherapy?

Autor: Correale P; Unit of Medical Oncology, Oncology Department, Grand Metropolitan Hospital 'Bianchi Melacrino Morelli', Reggio Calabria, Italy., Pentimalli F; Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy., Baglio G; Sbarro Institute for Cancer Research and Molecular Medicine, Philadelphia, PA, United States., Krstic-Demonacos M; Biomedical Research Center, School of Science, Engineering and Environment, University of Salford, Salford, United Kingdom., Saladino RE; Tissue Typing Unit, Grand Metropolitan Hospital 'Bianchi Melacrino Morelli', Reggio Calabria, Italy., Giordano A; Department of Medical Biotechnologies, University of Siena, Siena, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, United States., Mutti L; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2021 Mar 26; Vol. 12, pp. 638279. Date of Electronic Publication: 2021 Mar 26 (Print Publication: 2021).

HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis.

Autor: Correale P; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Saladino RE; Tissue Typing Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Giannarelli D; Biostatistical Unit, National Cancer Institute 'Regina Elena', IRCCS, 00161 Rome, Italy., Sergi A; Radiology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Mazzei MA; Department of Medical, Surgical and Neuro-Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy (RU-SI)., Bianco G; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Giannicola R; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Iuliano E; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Forte IM; Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy., Calandruccio ND; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Falzea AC; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Strangio A; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', 89124 Reggio Calabria, Italy (OU-RC)., Nardone V; Radiotherapy Unit, 'Ospedale del Mare', ASL Napoli 1, 80147 Naples, Italy., Pastina P; Section of Radiation Oncology, Medical School, University of Siena, 53100 Siena, Italy (ROU-SI)., Tini P; Section of Radiation Oncology, Medical School, University of Siena, 53100 Siena, Italy (ROU-SI)., Luce A; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Caraglia M; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.; Biogem Scarl, Institute of Genetic Research, Laboratory of Precision and Molecular Oncology, 83031 Ariano Irpino, Avellino, Italy., Caracciolo D; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy (MOU-CZ)., Mutti L; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA., Tassone P; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy (MOU-CZ).; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA., Pirtoli L; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA., Giordano A; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.; Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy., Tagliaferri P; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy (MOU-CZ).

Publikováno v: Cells [Cells] 2020 Aug 25; Vol. 9 (9). Date of Electronic Publication: 2020 Aug 25.

Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade.

Autor: Correale P; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy michele.caraglia@unicampania.it correalep@yahoo.com., Saladino RE; Tissue Typing Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Giannarelli D; Regina Elena National Cancer Institute, IRCCS, Rome, Italy., Giannicola R; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Agostino R; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Staropoli N; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy., Strangio A; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Del Giudice T; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy., Nardone V; Radiotherapy Unit, 'Ospedale del Mare', ASL Napoli 1, Naples, Italy., Altomonte M; Unit of Pharmacy, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Pastina P; Section of Radiation Oncology, Medical School, University of Siena, Siena, Italy., Tini P; Section of Radiation Oncology, Medical School, University of Siena, Siena, Italy., Falzea AC; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Imbesi N; Tissue Typing Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Arcati V; Tissue Typing Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Romeo G; Tissue Typing Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Caracciolo D; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy., Luce A; Department of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, Italy., Caraglia M; Department of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, Italy michele.caraglia@unicampania.it correalep@yahoo.com.; Biogem Scarl, Institute of Genetic Research, Laboratory of Precision and Molecular Oncology, Ariano Irpino, Avellino, Italy., Giordano A; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA.; Department of Medical Biotechnology, University of Siena, Siena, Italy., Pirtoli L; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA., Necas A; Central European Institute of Technology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic., Amler E; Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic., Barbieri V; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy., Tassone P; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA., Tagliaferri P; Medical and Translational Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Jun; Vol. 8 (1).

Could PD-1/PDL1 immune checkpoints be linked to HLA signature?

Autor: Correale P; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Saladino RE; Tissue Typing Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Nardone V; Radiotherapy Unit, 'Ospedale del Mare', Naples, Italy., Giannicola R; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Agostino R; Medical Oncology Unit, Grand Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Pirtoli L; Department of Biology, College of Science & Technology, Temple University, Philadelphia, PA, USA., Caraglia M; Department of Precision Medicine, University of Campania 'L. Vanvitelli', Via L. De Crecchio, 7 80138 Naples, Italy., Botta C; Hematology Unit, Annunziata Hospital, Cosenza, Italy., Tagliaferri P; Medical Oncology Unit, AUO 'MaterDomini' & 'Magna Graecia' University, Catanzaro, Italy.

Publikováno v: Immunotherapy [Immunotherapy] 2019 Dec; Vol. 11 (18), pp. 1523-1526. Date of Electronic Publication: 2019 Dec 09.