Výsledky vyhledávání - "Sakulrat Mankhong"

Akademický článek

The microbial metabolite p-cresol compromises the vascular barrier and induces endothelial cytotoxicity and inflammation in a 3D human vessel-on-a-chip

Autor: Sakulrat Mankhong, Thittaya Den-Udom, Tanotnon Tanawattanasuntorn, Thunwarat Suriyun, Kenjiro Muta, Chagriya Kitiyakara, Pimonrat Ketsawatsomkron

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Increased protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) are associated with cardiovascular diseases (CVDs); however, whether retention of PBUTs causes CVD remains unclear. Previous studies assessing the im

Externí odkaz: https://doaj.org/article/8bf9274c8db14364962a1926b08c4a8c

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Akademický článek

4-methoxycinnamyl p-coumarate reduces neuroinflammation by blocking NF-κB, MAPK, and Akt/GSK-3β pathways and enhancing Nrf2/HO-1 signaling cascade in microglial cells

Autor: Mayuree Poonasri, Sakulrat Mankhong, Natthakarn Chiranthanut, Klaokwan Srisook

Publikováno v: Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115808- (2023)

The active compound, 4-methoxycinnamyl p-coumarate (MCC), derived from the rhizome of Etlingera pavieana (Pierre ex Gagnep) R.M.Sm., has been shown to exert anti-inflammatory effects in several inflammatory models. However, its effects on microglial

Externí odkaz: https://doaj.org/article/078b5a3c4df74fe3b51adda7a4cefb67

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Akademický článek

Alzheimer’s cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans

Autor: Sohee Moon, Sujin Kim, Sakulrat Mankhong, Seong Hye Choi, Manu Vandijck, Vesna Kostanjevecki, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Bora Yoon, Hee Jin Kim, Jae-Won Jang, Jin Yong Hong, Dong-Ho Park, Leslie M. Shaw, Ju-Hee Kang

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)

Abstract Background Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarker cutoffs from immunoassays with low interlaboratory variability in diverse ethnic groups are necessary for their use in clinics and clinical trials. With lack of cutoff

Externí odkaz: https://doaj.org/article/e9227c4269a24457a12f5084fd26b37e

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Akademický článek

Sirtuin 1-dependent regulation of high mobility box 1 in hypoxia–reoxygenated brain microvascular endothelial cells: roles in neuronal amyloidogenesis

Autor: Young-Sun Lee, Ji-Young Choi, Sakulrat Mankhong, Sohee Moon, Sujin Kim, Young Ho Koh, Ji-Hye Kim, Ju-Hee Kang

Publikováno v: Cell Death and Disease, Vol 11, Iss 12, Pp 1-12 (2020)

Abstract Hypoxia–reperfusion injury is one of the major risk factors for neurodegeneration. However, it is unclear whether ischaemic damage in brain microvascular endothelial cells plays roles in neurodegeneration, particularly in the amyloidogenic

Externí odkaz: https://doaj.org/article/294d891d25da45cf9d9978b9333d3ad3

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Akademický článek

Development of Alzheimer’s Disease Biomarkers: From CSF- to Blood-Based Biomarkers

Autor: Sakulrat Mankhong, Sujin Kim, Seongju Lee, Hyo-Bum Kwak, Dong-Ho Park, Kyung-Lim Joa, Ju-Hee Kang

Publikováno v: Biomedicines, Vol 10, Iss 4, p 850 (2022)

In the 115 years since the discovery of Alzheimer’s disease (AD), our knowledge, diagnosis, and therapeutics have significantly improved. Biomarkers are the primary tools for clinical research, diagnostics, and therapeutic monitoring in clinical tr

Externí odkaz: https://doaj.org/article/c8b804f9fafa4ce3a8055554bf49ac6a

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Akademický článek

Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy

Autor: Sakulrat Mankhong, Sujin Kim, Sohee Moon, Hyo-Bum Kwak, Dong-Ho Park, Ju-Hee Kang

Publikováno v: Cells, Vol 9, Iss 6, p 1385 (2020)

Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength, and functions in elderly people. It is accompanied by physical frailty, functional disability, falls, hospitalization, and mortality, and is becoming a major geri

Externí odkaz: https://doaj.org/article/1f4f49ba35614fc0aeff1324860f24d7

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