SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice.

Autor: Dinnon KH 3rd; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Okuda K; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dang H; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Fritch EJ; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gully KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., De la Cruz G; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Evangelista MD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Asakura T; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gilmore RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hawkins P; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Nakano S; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., West A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Everman JL; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, USA., Sajuthi SP; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, USA., Zweigart MR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dong S; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., McBride J; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cooley MR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hines JB; Golden Point Scientific Laboratories, Hoover, AL 35216, USA., Love MK; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Groshong SD; Division of Pathology, Department of Medicine, National Jewish Health, Denver, CO 80206, USA., VanSchoiack A; NanoString Technologies, Seattle, WA 98109, USA., Phelan SJ; NanoString Technologies, Seattle, WA 98109, USA., Liang Y; NanoString Technologies, Seattle, WA 98109, USA., Hether T; NanoString Technologies, Seattle, WA 98109, USA., Leon M; NanoString Technologies, Seattle, WA 98109, USA., Zumwalt RE; Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA., Barton LM; Office of the Chief Medical Examiner, Oklahoma City, OK 73105, USA., Duval EJ; Office of the Chief Medical Examiner, Oklahoma City, OK 73105, USA., Mukhopadhyay S; Department of Pathology, Cleveland Clinic, Cleveland, OH 44195, USA., Stroberg E; Office of the Chief Medical Examiner, Oklahoma City, OK 73105, USA., Borczuk A; Weill Cornell Medicine, New York, NY 10065, USA., Thorne LB; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sakthivel MK; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lee YZ; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hagood JS; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Pulmonology Division and Program for Rare and Interstitial Lung Disease, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Mock JR; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Seibold MA; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, USA.; Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO 80045, USA., O'Neal WK; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Montgomery SA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Boucher RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baric RS; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Rapidly Emerging Antiviral Drug Discovery Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2022 Sep 28; Vol. 14 (664), pp. eabo5070. Date of Electronic Publication: 2022 Sep 28.

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies.

Autor: Dinnon KH 3rd; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Okuda K; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Dang H; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Fritch EJ; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Gully KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., De la Cruz G; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Evangelista MD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Asakura T; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Gilmore RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hawkins P; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Nakano S; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., West A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Everman JL; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA., Sajuthi SP; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA., Zweigart MR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Dong S; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., McBride J; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Cooley MR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hines JB; Golden Point Scientific Laboratories, Hoover, Alabama, USA., Love MK; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Groshong SD; Division of Pathology, Department of Medicine, National Jewish Health, Denver, Colorado, USA., VanSchoiack A; NanoString Technologies, Seattle, Washington, USA., Phelan SJ; NanoString Technologies, Seattle, Washington, USA., Liang Y; NanoString Technologies, Seattle, Washington, USA., Hether T; NanoString Technologies, Seattle, Washington, USA., Leon M; NanoString Technologies, Seattle, Washington, USA., Zumwalt RE; Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA., Barton LM; Office of the Chief Medical Examiner, Oklahoma City, Oklahoma, USA., Duval EJ; Office of the Chief Medical Examiner, Oklahoma City, Oklahoma, USA., Mukhopadhyay S; Department of Pathology, Cleveland Clinic, Cleveland, Ohio, USA., Stroberg E; Office of the Chief Medical Examiner, Oklahoma City, Oklahoma, USA., Borczuk A; Weill Cornell Medicine, New York, New York, USA., Thorne LB; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sakthivel MK; Department of Radiology, University of North Carolina at Chapel Hill, North Carolina, USA., Lee YZ; Department of Radiology, University of North Carolina at Chapel Hill, North Carolina, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hagood JS; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pediatrics, Pulmonology Division and Program for Rare and Interstitial Lung Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Mock JR; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Seibold MA; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.; Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado-Denver, Denver, Colorado, USA., O'Neal WK; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Montgomery SA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Boucher RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Baric RS; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Rapidly Emerging Antiviral Drug Discovery Initiative, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Feb 15. Date of Electronic Publication: 2022 Feb 15.

Intramural Esophageal Abscess Complicated with Pleural Fistula: A Case Report.

Autor: Kumar S; Radiology, Shri Sai Hospital, Patna, IND., Sakthivel MK; Radiology, University of North Carolina School of Medicine, Chapel Hill, USA., Bosemani T; Radiology, University of North Carolina School of Medicine, Chapel Hill, USA.

Publikováno v: Cureus [Cureus] 2020 Feb 02; Vol. 12 (2), pp. e6846. Date of Electronic Publication: 2020 Feb 02.