Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives

Autor: Ashok K. Prasad, Pei Cao, Jesper Wengel, Akanksha Matta, Erik V. Van der Eycken, Ajendra K. Sharma, Christophe Len, Virinder S. Parmar, Sakshi Balwani, Shilpi Tomar, Balaram Ghosh, Brajendra K. Singh, Anthony L. DePass, Sandeep Kumar

Publikováno v: Matta, A, Sharma, A K, Tomar, S, Cao, P, Kumar, S, Balwani, S, Ghosh, B, Prasad, A K, Van Der Eycken, E V, Depass, A L, Wengel, J, Parmar, V S, Len, C & Singh, B K 2020, ' Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives ', New Journal of Chemistry, vol. 44, no. 32, pp. 13716-13727 . https://doi.org/10.1039/d0nj02125c

In an effort to develop potent anti-inflammatory agents, a series of novel chroman derivatives including acyclic amidochromans, chromanyl esters and chromanyl acrylates have been designed, synthesized and fully characterized. These chroman analogues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a605720ec6febd9cea65c63471dbf0
https://findresearcher.sdu.dk:8443/ws/files/178322929/revised_njc.pdf

Synthesis and Evaluation of 2,2-Dimethylchroman Derivatives as Inhibitors of ICAM-1 Expression on Human Endothelial Cells

Autor: Virinder S. Parmar, Ashok K. Prasad, Sakshi Balwani, Balaram Ghosh, Ashish Dhawan

Publikováno v: Journal of Heterocyclic Chemistry. 51:1712-1719

We herein report the synthesis of novel 2,2-dimethylchroman analogs and their effect on the modulation of tumor necrosis factor-α-induced expression of intercellular adhesion molecule-1 in human endothelial cells. These compounds were found to be po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::055568f073d6f83462c8a6988d5379fc
https://doi.org/10.1002/jhet.1860

Additional file 1: Figure S1. of The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer

Autor: Tamir, Ayala, Gangadharan, Anju, Sakshi Balwani, Takemi Tanaka, Ushma Patel, Hassan, Ahmed, Benke, Stephanie, Agas, Agnieszka, D’Agostino, Joseph, Dayoung Shin, Sunghoon Yoon, Goy, Andre, Pecora, Andrew, K. Suh

Characterization of custom-made PRSS8 primary antibody. Optimization of PRSS8 concentration by immunoblot (A). OD reading as a function of PRSS8 concentration as measured by Elisa (B). 1st bleed and 2nd bleed were normally taken on days 17 and 31, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1242913633fb09acadbef1db977e9e

Selective biocatalytic aminolysis of (±)-epichlorohydrin: Synthesis and ICAM-1 inhibitory activity of (S)-(+)-3-arylamino-1-chloropropan-2-ols

Autor: Ashok K. Prasad, Balaram Ghosh, Pankaj Gupta, Ashish Dhawan, Sakshi Balwani, Virinder S. Parmar, Raju Brahma, R. K. Singh, Sumati Bhatia, Shatrughan Sharma

Publikováno v: Bioorganic & Medicinal Chemistry. 19:2263-2268

Regio- and enantioselective synthesis of (S)-(+)-3-arylamino-1-chloropropan-2-ols has been achieved by the epoxide ring opening of (±)-epichlorohydrin with different aromatic amines in the presence of Candida rugosa lipase. Activities of seven model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06813eaa784a2af474215aca18571bf5
https://doi.org/10.1016/j.bmc.2011.02.029

Ethyl gallate isolated from Pistacia integerrima Linn. inhibits cell adhesion molecules by blocking AP-1 transcription factor

Autor: Ankur Kulshreshtha, Debkumar Nandi, Parasuraman Jaisankar, Balaram Ghosh, Kamiya Mehla, Sakshi Balwani

Publikováno v: Journal of ethnopharmacology. 137(3)

Ethnopharmacological relevance Galls from Pistacia integerrima Linn. (kakadshringhi) have been used as therapeutic agent for various inflammatory diseases in Indian system of traditional medicine. However, the active constituents underlying the medic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0b286d6650fabbd0c86eb7cbfe66b0
https://pubmed.ncbi.nlm.nih.gov/21843619