Výsledky vyhledávání - "Saksham Palawat"

Synthesis, molecular modelling, in vitro and in vivo evaluation of conophylline inspired novel benzyloxy substituted indole glyoxylamides as potent pancreatic lipase inhibitors

Autor: Pracheta Sengupta, Sridhar S.N.C., Ginson George, Atish T. Paul, Saksham Palawat, Dileep P. S

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:9530-9542

Pancreatic lipase is a digestive enzyme involved in the hydrolysis of dietary fats. Orlistat, a potent pancreatic lipase inhibitor, is widely prescribed for long-term obesity treatment. Nevertheless, orlistat is reported for severe adverse effects in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abca1bc795f2773f72ebae45c2c7be8
https://doi.org/10.1080/07391102.2021.1930168

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Design, synthesis, biological evaluation and molecular modelling studies of conophylline inspired novel indolyl oxoacetamides as potent pancreatic lipase inhibitors

Autor: Atish T. Paul, Saksham Palawat, S. N. C. Sridhar

Publikováno v: New Journal of Chemistry. 44:12355-12369

A novel series of 21 indolyl oxoacetamide analogues was designed based on the natural product lead conophylline, and evaluated for their pancreatic lipase inhibitory activity using porcine pancreatic lipase (Type II). Analogues 12c and 12b exhibited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::503c0a4a37ed825653dddb2deab8bd13
https://doi.org/10.1039/d0nj02622k

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Synthesis, molecular modelling

Autor: Sridhar, S N C, Pracheta, Sengupta, Saksham, Palawat, Dileep, P S, Ginson, George, Atish T, Paul

Publikováno v: Journal of biomolecular structuredynamics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d5be09e3c47514086e3abda595d046b
https://pubmed.ncbi.nlm.nih.gov/34032197

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Design, synthesis, evaluation, and molecular modeling studies of indolyl oxoacetamides as potential pancreatic lipase inhibitors

Autor: Saksham Palawat, S. N. C. Sridhar, Atish T. Paul

Publikováno v: Archiv der Pharmazie. 353:2000048

A series of indolyl oxoacetamide analogs was synthesized, characterized, and evaluated for their pancreatic lipase inhibitory activity using porcine pancreatic lipase (type II) and 4-nitrophenyl butyrate. Compound 8d exhibited a potent inhibition, wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb752bd09303267c7804a21cdab624cd
https://doi.org/10.1002/ardp.202000048

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Design, synthesis, biological evaluation and molecular modelling studies of indole glyoxylamides as a new class of potential pancreatic lipase inhibitors

Autor: S. N. C. Sridhar, Atish T. Paul, Saksham Palawat

Publikováno v: Bioorganic chemistry. 85

A series of eighteen indole glyoxylamide analogues were synthesized, characterized and evaluated for their pancreatic lipase inhibitory activity. Porcine pancreatic lipase (Type II) was used with 4-nitrophenyl butyrate (as substrate) for the in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95652228cdfb8b50bbe6f3f96e6585ee
https://pubmed.ncbi.nlm.nih.gov/30658237

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