Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sakiya Kawada"'
Autor:
Andrejs Tučs, Tomoyuki Ito, Yoichi Kurumida, Sakiya Kawada, Hikaru Nakazawa, Yutaka Saito, Mitsuo Umetsu, Koji Tsuda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract In designing functional biological sequences with machine learning, the activity predictor tends to be inaccurate due to shortage of data. Top ranked sequences are thus unlikely to contain effective ones. This paper proposes to take predicti
Externí odkaz:
https://doaj.org/article/0d7e74484286481ca47596de9fb39a2c
Autor:
Tomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda, Mitsuo Umetsu
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTDespite the advances in surface-display systems for directed evolution, variants with high affinity are not always enriched due to undesirable biases that increase target-unrelated variants during biopanning. Here, our goal was to design a li
Externí odkaz:
https://doaj.org/article/006271d38f2946dbaf222d586d863779
Autor:
Mitsuo Umetsu, Hafumi Nishi, Mayu Yoshida, Hikaru Nakazawa, Reito Fukazawa, Sakiya Kawada, Tomoyuki Ito, Tomoshi Kameda
Publikováno v:
Chemistry Letters. 50:1867-1871
Antibody mimetics are proteins smaller than antibodies that have antigen-binding properties. Here, we used a combination of informatic selection and experimental verification to identify from a pub...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1b742573a5e70ab7a37a55852f006f8
https://doi.org/10.1246/cl.210443
https://doi.org/10.1246/cl.210443
Autor:
Ryosuke Fujiwara, Mariko Nakano, Yuuki Hirata, Chisako Otomo, Daisuke Nonaka, Sakiya Kawada, Hikaru Nakazawa, Mitsuo Umetsu, Tomokazu Shirai, Shuhei Noda, Tsutomu Tanaka, Akihiko Kondo
Publikováno v:
Metabolic engineering. 72
Escherichia coli, the most studied prokaryote, is an excellent host for producing valuable chemicals from renewable resources as it is easy to manipulate genetically. Since the periplasmic environment can be easily controlled externally, elucidating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68559de471a6bf8bef3a3d098fa1241c
https://pubmed.ncbi.nlm.nih.gov/35257866
https://pubmed.ncbi.nlm.nih.gov/35257866
Autor:
Taiji Katsuki, Takeshi Yokoyama, Yoshikazu Tanaka, Sakiya Kawada, Tomoyuki Ito, Hikaru Nakazawa, Mitsuo Umetsu, Takashi Matsui, Atsushi Tsugita
Phage display and biopanning is a powerful tool for generating binding molecules for a specific target. However, the selection process based on binding affinity provides no assurance for the antibody’s affinity to the target epitope. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd4f8481027b82803323cc3be6c3dc8c
https://doi.org/10.21203/rs.3.rs-757826/v1
https://doi.org/10.21203/rs.3.rs-757826/v1
Autor:
Tomoyuki Ito, Hafumi Nishi, Tomoshi Kameda, Mayu Yoshida, Reito Fukazawa, Sakiya Kawada, Hikaru Nakazawa, Mitsuo Umetsu
Publikováno v:
Chemistry Letters; Nov2021, Vol. 50 Issue 11, p1867-1871, 5p