TDP1 and TOP1 as targets in anticancer treatment of NSCLC:Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data

Autor: Ann-Katrine Jakobsen, Sakineh Yuusufi, Line Bille Madsen, Peter Meldgaard, Birgitta R. Knudsen, Magnus Stougaard

Publikováno v: Jakobsen, A K, Yuusufi, S, Madsen, L B, Meldgaard, P, Knudsen, B R & Stougaard, M 2022, ' TDP1 and TOP1 as targets in anticancer treatment of NSCLC : Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data ', Lung Cancer, vol. 164, pp. 23-32 . https://doi.org/10.1016/j.lungcan.2021.12.010

Objectives: Topoisomerase 1 (TOP1) is a drug target used in anticancer treatment of various cancer types. The effect of the TOP1 drugs can be counteracted by the enzymatic activity of tyrosyl-DNA phosphodiesterase 1 (TDP1). Thus, to elucidate the rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b1c704673e73ff07059ce5c38440af
https://pure.au.dk/portal/da/publications/tdp1-and-top1-as-targets-in-anticancer-treatment-of-nsclc(05d8dc98-0db1-43c9-ad57-f8da63558d2f).html

Solar elastosis and TERT promoter mutations in cutaneous melanoma

Autor: Johanne Lade Keller, Sakineh Yuusufi, Rikke Riber-Hansen, Torben Steiniche, Magnus Stougaard

Publikováno v: Keller, J L, Yuusufi, S, Riber-Hansen, R, Steiniche, T & Stougaard, M 2018, ' Solar elastosis and TERT promoter mutations in cutaneous melanoma ', pp. 398-409 .
Aarhus University

The aims of this study were to assess the prognostic potential of solar elastosis grading and telomerase reverse transcriptase (TERT) promoter mutations (TERTpmut) in melanoma and to evaluate whether an association between solar elastosis and TERTpmu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::320731a82771709a3c0cdda598772571
https://pure.au.dk/portal/da/publications/solar-elastosis-and-tert-promoter-mutations-in-cutaneous-melanoma(2ec5f82d-134d-4a55-a180-b4625c73e642).html