Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Sakina B Gooljar"'
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The Cytosolic Chaperone Hsc70 Promotes Traffic to the Cell Surface of Intracellular Retained Melanocortin-4 Receptor Mutants
Autor: Adrian J. L. Clark, J. Paul Chapple, Sakina B. Gooljar, Lucia Anthonypillai, Eirini Meimaridou, Nalini Ramnarace
Publikováno v: Molecular Endocrinology. 25:1650-1660
Inherited modifications in protein structure frequently cause a loss-of-function by interfering with protein synthesis, transport, or stability. For the obesity-linked melanocortin-4 receptor (MC4R) and other G protein-coupled receptors, many mutants
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7bd552c642b1380c5e64be4dfb7eb5
https://doi.org/10.1210/me.2011-1020
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3
From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery
Autor: J. Paul Chapple, Eirini Meimaridou, Sakina B. Gooljar
Publikováno v: Journal of Molecular Endocrinology. 42:1-9
Molecular chaperones are best recognized for their roles in de novo protein folding and the cellular response to stress. However, many molecular chaperones, and in particular the Hsp70 chaperone machinery, have multiple diverse cellular functions. At
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262fd5bb88ec28a6e0aa40105c2c7790
https://doi.org/10.1677/jme-08-0116
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4
Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile
Autor: Harold Snieder, Sandra D. O'Dell, Theodosios Kyriakou, Ramasamyiyer Swaminathan, Sakina B. Gooljar, Dongliang Ge, Laura J. Collins, Tim D. Spector
Publikováno v: Obesity, 16(2), 492-496. Wiley-Blackwell
The leptin signal is transduced via the JAK2-STAT3 (Janus kinase 2-signal transducer and activator of transcription-3) pathway at the leptin receptor. JAK2 also phosphorylates insulin receptor substrate, integral to insulin and leptin action and is r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4282b7ff074d2b11139cce4e201bbdeb
https://doi.org/10.1038/oby.2007.79
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5
SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women
Autor: Harold Snieder, Yalda Jamshidi, Rami Swaminathan, Dongliang Ge, Xiaoling Wang, Sakina B. Gooljar, Tim D. Spector, Sandra D. O'Dell
Publikováno v: Atherosclerosis. 194:e26-e33
Insulin regulates apoB metabolism via activation of PI3K or regulation of MTP via MAPK/ERK signalling. SHP-2 enhances both pathways through increased IRS-1 phosphorylation. We hypothesized that variants in the SHP-2 gene PTPN11 and PI3K p85alpha subu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f0e938d587cb4c78626ad68b0d9187
https://doi.org/10.1016/j.atherosclerosis.2006.12.013
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6
Common STAT3 variants are not associated with obesity or insulin resistance in female twins
Autor: Sandra D. O'Dell, Xiaoling Wang, Tim D. Spector, Carl A. Lane, Theodosios Kyriakou, Sakina B. Gooljar, Laura J. Collins, Yalda Jamshidi, Harold Snieder
Publikováno v: Obesity, 15(7), 1634-1639. Wiley-Blackwell
JAMSHIDI, YALDA, THEODOSIOS KYRIAKOU, SAKINA B. GOOLJAR, LAURA J. COLLINS, CARL A. LANE, HAROLD SNIEDER, XIAOLING WANG, TIM D. SPECTOR, AND SANDRA D. O'DELL. Common STAT3 variants are not associated with obesity or insulin resistance in female twins.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac5fe87379e26396192ab76ca41ee36
https://research.rug.nl/en/publications/525e2ef3-d240-4a94-b356-7c912beaac97
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