Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Saki Sono"'
Autor:
Saki Sono, Richard G. Kibbey, Peter S. Yoo, Gary W. Cline, Tiago C. Alves, Sylvie Dufour, Gerald I. Shulman, Katsutaro Morino, Kitt Falk Petersen
Publikováno v:
Proceedings of the National Academy of Sciences. 112:11330-11334
Previous studies have implicated age-associated reductions in mitochondrial oxidative phosphorylation activity in skeletal muscle as a predisposing factor for intramyocellular lipid (IMCL) accumulation and muscle insulin resistance (IR) in the elderl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbe3e467c3ed88d07ca82a17bece250
https://doi.org/10.1073/pnas.1514844112
https://doi.org/10.1073/pnas.1514844112
Autor:
Atsunori Kashiwagi, Robert H. Eckel, Katsutaro Morino, Ira J. Goldberg, Hong Wang, Varman T. Samuel, Amy Gallo, Cheol Soo Choi, Saki Sono, Hiroshi Maegawa, Kitt Falk Petersen, Hongyu Zhao, Aiping Lin, Gerald I. Shulman
Publikováno v:
Diabetes
Recent studies reveal a strong relationship between reduced mitochondrial content and insulin resistance in human skeletal muscle, although the underlying factors responsible for this association remain unknown. To address this question, we analyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248f856a2c7a2149ae48b180fc190670
https://doi.org/10.2337/db11-1391
https://doi.org/10.2337/db11-1391
Autor:
Yasuhide Asaumi, Koji Ohashi, Saki Sono-Romanelli, Yuichi Oshima, Akiko Higuchi, Noriyuki Ouchi, Kenneth Walsh
Publikováno v:
Journal of Biological Chemistry. 285:7127-7134
FSTL1 is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a9363d80eb622694c8809b2c2ce3a9
https://doi.org/10.1074/jbc.m109.069468
https://doi.org/10.1074/jbc.m109.069468
Autor:
Kenneth Walsh, Saki Sono-Romanelli, Toni-Ann S. Duhaney, Deepa S. De Silva, Noriyuki Ouchi, Fuzhong Qin, Richard M. Wilson, Akiko Higuchi, Flora Sam, Koji Ohashi, Kaori Sato
Publikováno v:
Endocrinology. 151:322-331
Aldosterone infusion results in left ventricular hypertrophy (LVH) and hypertension and may involve profibrotic and proinflammatory mechanisms. In turn, hypertension is the major cause of diastolic heart failure (HF). Adiponectin, an adipose-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e17396f79b5bebc187c8eb7ee42d70c
https://doi.org/10.1210/en.2009-0806
https://doi.org/10.1210/en.2009-0806
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:46-53
Background— The insulin-sensitizing agents referred to as thiazolidinediones (TZDs) possess antiatherogenic and anti-inflammatory actions that contribute to protection against diabetic macrovascular complications. However, little is known about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec156c91f3e64656ba3eae7528e1b7a
https://doi.org/10.1161/atvbaha.109.198465
https://doi.org/10.1161/atvbaha.109.198465
Autor:
Varman T. Samuel, Richard M. Reznick, William M. Philbrick, Saki Sono, David Sebastián, Gerald I. Shulman, Morris F. White, Irene K. Moore, Yoshio Nagai, Katsutaro Morino, Susanne Neschen, Dimitrios N. Tsirigotis, Stefan Bilz
Publikováno v:
Diabetes
OBJECTIVE—Insulin resistance in skeletal muscle plays a critical role in the pathogenesis of type 2 diabetes, yet the cellular mechanisms responsible for insulin resistance are poorly understood. In this study, we examine the role of serine phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9ef3dc14461f035340c6e582dcefe3
http://europepmc.org/articles/PMC2551673
http://europepmc.org/articles/PMC2551673
Autor:
Gary W. Cline, Gerald I. Shulman, Katsutaro Morino, Saki Sono, Matthew P. Gillum, Rebecca L. Pongratz, Jörg C. Rossbacher, Susanne Neschen
Publikováno v:
Diabetes. 55:924-928
Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: fish oilPathways studied: adiponectin gene expressionStudy type (in vitro, animals, humans): 129Sv miceTissue/biological material/sample size: total plasmaMode of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7a88d96c8c3ca788f452ce53196f36
https://doi.org/10.2337/diabetes.55.04.06.db05-0985
https://doi.org/10.2337/diabetes.55.04.06.db05-0985
Autor:
Kiyoshi Matsuo, Yasutomo Kisu, Kazuhide Yahata, Tsuyoshi Sumiya, Atsushi Murase, Saki Sono, Riyo Morishita, Toshihiro Kuroita, Naoko Kagawa, Kouichi Kimura, Kazuyoshi Minami, Ryohei Satoh, Yaeta Endo, Shinya Watanabe, Mariko Mitsubori, Nobuo Nomura, Miki Kobayashi, Tetsuo Nishikawa, Junichi Yamamoto, Yoshifumi Kawamura, Toshihiko Okamoto, Keiichi Kanehori, Fumio Imamoto, Aya Miura, Hiroyuki Takeda, Akiko Fukumoto, Reiko Honma, Yukio Maruyama, Naoki Goshima, Hisashi Kuwayama, Yuki Iida, Yuka Yanagisawa, Noriko Sakagami, Akira Nishikawa, Masatoshi Mori, Yukiko Takayama, Shigeo Tanaka, Hiroko Yamada, Kumiko Ishikawa, Ai Wakamatsu, Rie Kimura, Shigemichi Nishikawa, Akio Sugiyama, Chie Kaminaga, Kiyokazu Kenmochi, Yukari Sasaki, Bunsei Kawakami, Taichi Andoh, Takao Isogai, Emi Ito, Takushi Togashi, Tomoko Takayama, Tomoe Seki, Yutaka Sakamoto, Jun-ichi Imai
Publikováno v:
Nature methods. 5(12)
Appropriate resources and expression technology necessary for human proteomics on a whole-proteome scale are being developed. We prepared a foundation for simple and efficient production of human proteins using the versatile Gateway vector system. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37544d5fae7b300fe8f01e3359f7b56c
https://pubmed.ncbi.nlm.nih.gov/19054851
https://pubmed.ncbi.nlm.nih.gov/19054851
Autor:
Gerald I. Shulman, Jared Frattini, Morris F. White, Marc Pypaert, Katsutaro Morino, Kitt Falk Petersen, Sylvie Dufour, Stefan Bilz, Saki Sono, Douglas E. Befroy, Susanne Neschen, Nadine Shatzkes
Publikováno v:
The Journal of clinical investigation. 115(12)
To further explore the nature of the mitochondrial dysfunction and insulin resistance that occur in the muscle of young, lean, normoglycemic, insulin-resistant offspring of parents with type 2 diabetes (IR offspring), we measured mitochondrial conten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957ba26bbfb1a82ee8907c24c9778cbf
https://pubmed.ncbi.nlm.nih.gov/16284649
https://pubmed.ncbi.nlm.nih.gov/16284649