Výsledky vyhledávání

Akademický článek

Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes

Autor: Masahiro Oka, Sonoko Mura, Kohji Yamada, Percival Sangel, Saki Hirata, Kazumitsu Maehara, Koichi Kawakami, Taro Tachibana, Yasuyuki Ohkawa, Hiroshi Kimura, Yoshihiro Yoneda

Publikováno v: eLife, Vol 5 (2016)

The nucleoporin Nup98 is frequently rearranged to form leukemogenic Nup98-fusion proteins with various partners. However, their function remains largely elusive. Here, we show that Nup98-HoxA9, a fusion between Nup98 and the homeobox transcription fa

Externí odkaz: https://doaj.org/article/c353315944594a2f8a37bb8c03434ee0

Zobrazit plný text záznamu

Synthesis and evaluation of a multifunctional probe with a high affinity for prostate-specific membrane antigen (PSMA) and bone

Autor: Saki Hirata, Kenji Mishiro, Takuma Higashi, Takeshi Fuchigami, Masayuki Munekane, Yasushi Arano, Seigo Kinuya, Kazuma Ogawa

Publikováno v: Nuclear Medicine and Biology. :34-41

Prostate cancer frequently metastasizes to the bone. Because patients with bone metastases suffer from skeletal-related events, the diagnosis and treatment of bone metastases in the early stage are important. In this study, to improve the sensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e7571ca66b775ffdfd6f1be37ae0eb
https://doi.org/10.1016/j.nucmedbio.2022.08.004

Zobrazit plný text záznamu

Development of tumor-targeting aza-vesamicol derivatives with high affinity for sigma receptors for cancer theranostics

Autor: Kenji Mishiro, Mengfei Wang, Saki Hirata, Takeshi Fuchigami, Kazuhiro Shiba, Seigo Kinuya, Kazuma Ogawa

Publikováno v: RSC Med Chem

As sigma receptors are highly expressed on various cancer cells, radiolabeled sigma receptor ligands have been developed as imaging and therapeutic probes for cancer. Previously, we synthesized and evaluated a radioiodinated vesamicol derivative, 2-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d3471e46f7a4819f69678bd467ac78
https://doi.org/10.1039/d2md00099g

Zobrazit plný text záznamu

68Ga- and 211At-Labeled RGD Peptides for Radiotheranostics with Multiradionuclides

Autor: Saki Hirata, Seigo Kinuya, Kazuma Ogawa, Kenji Mishiro, Kohshin Washiyama, Hiroaki Echigo, Yoji Kitamura, Kazuhiro Shiba, Kazuhiro Takahashi

Publikováno v: Molecular Pharmaceutics. 18:3553-3562

Probes for radiotheranostics could be produced by introducing radionuclides with similar chemical characteristics into the same precursors. We recently developed an 211At-labeled RGD peptide and a corresponding radioiodine-labeled RGD peptide. Both l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00b7bce06dcc6f8f4ca594c54b930db7
https://doi.org/10.1021/acs.molpharmaceut.1c00460

Zobrazit plný text záznamu

ZnO nanoparticles effect on pollen grain germination and pollen tube elongation

Autor: Kasumi Yamamoto, Yoshino Nakajima, Hayato Tokumoto, Saki Hirata, Shizue Yoshihara, Kensuke Kurahashi

Publikováno v: Plant Cell, Tissue and Organ Culture (PCTOC). 145:405-415

Plant germ cells, such as pollen grains, can be affected by exposure to metal nanoparticles (NPs) that have diffused into the environment. The germination and tube elongation of pollen grain (Lilium longiflorum) exposed to low-solubility NPs was obse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::285ce8cda0b412ea4a5e23164fe7f314
https://doi.org/10.1007/s11240-021-02017-2

Zobrazit plný text záznamu