Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.

Autor: Sake SM; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Zhang X; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Rajak MK; Institute of Virology, Hannover Medical School, Hannover, Germany.; Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of Luebeck, Luebeck, Germany., Urbanek-Quaing M; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Carpentier A; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Gunesch AP; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Grethe C; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Matthaei A; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Rückert J; Institute of Virology, Hannover Medical School, Hannover, Germany., Galloux M; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France., Larcher T; INRAE Oniris, PAnTher, APEX, Oniris, Nantes, France., Le Goffic R; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France., Hontonnou F; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France., Chatterjee AK; Calibr, Scripps Research, La Jolla, CA, USA., Johnson K; Calibr, Scripps Research, La Jolla, CA, USA., Morwood K; Calibr, Scripps Research, La Jolla, CA, USA., Rox K; Department of Chemical Biology, Helmholtz Center of Infection Research, Braunschweig, Germany.; German Centre for Infection Research, Partner site Braunschweig-Hannover, Braunschweig, Germany., Elgaher WAM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-HZI, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Huang J; Insitute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wetzke M; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany., Hansen G; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany., Fischer N; Insitute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Eléouët JF; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France., Rameix-Welti MA; Université Paris-Saclay, Université de Versailles St. Quentin; UMR 1173 (2I), INSERM; Assistance Publique des Hôpitaux de Paris, Hôpital Ambroise Paré, Laboratoire de Microbiologie, DMU15, Versailles, France., Hirsch AKH; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-HZI, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Helmholtz International Lab for Anti-infectives, HZI, Braunschweig, Germany., Herold E; Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of Luebeck, Luebeck, Germany., Empting M; German Centre for Infection Research, Partner site Braunschweig-Hannover, Braunschweig, Germany.; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-HZI, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Lauber C; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Schulz TF; Institute of Virology, Hannover Medical School, Hannover, Germany.; German Centre for Infection Research, Partner site Braunschweig-Hannover, Braunschweig, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Krey T; Institute of Virology, Hannover Medical School, Hannover, Germany.; Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of Luebeck, Luebeck, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany.; German Center for Infection Research, Partner Site Hamburg-Luebeck-Borstel-Riems, Luebeck, Germany., Haid S; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany. sibylle.haid@twincore.de., Pietschmann T; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany. thomas.pietschmann@twincore.de.; German Centre for Infection Research, Partner site Braunschweig-Hannover, Braunschweig, Germany. thomas.pietschmann@twincore.de.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. thomas.pietschmann@twincore.de.; Helmholtz International Lab for Anti-infectives, HZI, Braunschweig, Germany. thomas.pietschmann@twincore.de.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 08; Vol. 15 (1), pp. 1173. Date of Electronic Publication: 2024 Feb 08.

HPR114 Is No Therapy a Therapy? Effects of Watchful Waiting as Appropriate Comparator Therapy for New Drugs on Benefit Assessment and Pricing in Germany

Autor: Berger, I, Richter, N, Martyniszyn-Eiben, A, Sake, SM, Glüsen, M, Kielhorn-Schönermark, H, Schönermark, M

Publikováno v: In Value in Health December 2022 25(12) Supplement:S252-S253

A condensate-hardening drug blocks RSV replication in vivo.

Autor: Risso-Ballester J; Université Paris-Saclay, INSERM, Université de Versailles St Quentin, UMR 1173 (2I), Versailles, France., Galloux M; Unité de Virologie et Immunologie Moléculaires (UR892), INRAE, Université Paris-Saclay, Jouy-en-Josas, France., Cao J; Helmholtz International Lab for Anti-Infectives, State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, P. R. China., Le Goffic R; Unité de Virologie et Immunologie Moléculaires (UR892), INRAE, Université Paris-Saclay, Jouy-en-Josas, France., Hontonnou F; Unité de Virologie et Immunologie Moléculaires (UR892), INRAE, Université Paris-Saclay, Jouy-en-Josas, France., Jobart-Malfait A; Université Paris-Saclay, INSERM, Université de Versailles St Quentin, UMR 1173 (2I), Versailles, France., Desquesnes A; Université Paris-Saclay, INSERM, Université de Versailles St Quentin, UMR 1173 (2I), Versailles, France., Sake SM; Helmholtz International Lab for Anti-Infectives, Institute for Experimental Virology, Twincore - Centre for Experimental and Clinical Infection Research, Hannover, Germany., Haid S; Helmholtz International Lab for Anti-Infectives, Institute for Experimental Virology, Twincore - Centre for Experimental and Clinical Infection Research, Hannover, Germany., Du M; Helmholtz International Lab for Anti-Infectives, State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, P. R. China., Zhang X; Helmholtz International Lab for Anti-Infectives, State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, P. R. China., Zhang H; Helmholtz International Lab for Anti-Infectives, State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, P. R. China., Wang Z; Qingdao Municipal Center for Disease Control and Prevention, Qingdao, P. R. China., Rincheval V; Université Paris-Saclay, INSERM, Université de Versailles St Quentin, UMR 1173 (2I), Versailles, France., Zhang Y; Helmholtz International Lab for Anti-Infectives, State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, P. R. China., Pietschmann T; Helmholtz International Lab for Anti-Infectives, Institute for Experimental Virology, Twincore - Centre for Experimental and Clinical Infection Research, Hannover, Germany., Eléouët JF; Unité de Virologie et Immunologie Moléculaires (UR892), INRAE, Université Paris-Saclay, Jouy-en-Josas, France. jean-francois.eleouet@inrae.fr., Rameix-Welti MA; Université Paris-Saclay, INSERM, Université de Versailles St Quentin, UMR 1173 (2I), Versailles, France. marie-anne.rameix-welti@uvsq.fr.; Assistance Publique des Hôpitaux de Paris, Université Paris Saclay, Hôpital Ambroise Paré, Laboratoire de Microbiologie, Boulogne-Billancourt, France. marie-anne.rameix-welti@uvsq.fr., Altmeyer R; Helmholtz International Lab for Anti-Infectives, State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, P. R. China. ralf.marius.altmeyer@gmail.com.; School of Public Health, University of Hong Kong, Hong Kong SAR, P. R. China. ralf.marius.altmeyer@gmail.com.

Publikováno v: Nature [Nature] 2021 Jul; Vol. 595 (7868), pp. 596-599. Date of Electronic Publication: 2021 Jul 07.

Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry.

Autor: Blockus S; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Sake SM; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Wetzke M; Department for Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany; German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany., Grethe C; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany., Graalmann T; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany; Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany., Pils M; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany., Le Goffic R; Unité de Virologie et Immunologie Moléculaires, INRA, Université Paris Saclay, Jouy-en-Josas, France., Galloux M; Unité de Virologie et Immunologie Moléculaires, INRA, Université Paris Saclay, Jouy-en-Josas, France., Prochnow H; Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany; German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany., Rox K; Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany; German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany., Hüttel S; Department Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany., Rupcic Z; Department Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany., Wiegmann B; Lower Saxony Center for Biomedical Engineering, Implant Research and Development, Hannover Medical School, Hannover, Germany; Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; Member of the German Centre for Lung Research (DZL), Hannover, Germany., Dijkman R; Institute of Virology and Immunology (IVI), Bern and Mittelhäusern, Switzerland; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Switzerland; Institute for Infectious Diseases, University of Bern, Switzerland., Rameix-Welti MA; UMR1173, Institute National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles St. Quentin, Montigny-le-Bretonneux, France., Eléouët JF; Unité de Virologie et Immunologie Moléculaires, INRA, Université Paris Saclay, Jouy-en-Josas, France., Duprex WP; University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Thiel V; Institute of Virology and Immunology (IVI), Bern and Mittelhäusern, Switzerland; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Switzerland., Hansen G; Department for Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Brönstrup M; Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany; German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany., Haid S; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany. Electronic address: sibylle.haid@twincore.de., Pietschmann T; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany; German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. Electronic address: thomas.pietschmann@twincore.de.

Publikováno v: Antiviral research [Antiviral Res] 2020 May; Vol. 177, pp. 104774. Date of Electronic Publication: 2020 Mar 18.

Repurposing of a library for high-content screening of inhibitors against Echinococcus granulosus.

Autor: Zheng, Weinan¹ (AUTHOR) weinan.zheng@ghddi.org, Lv, Gaofei¹ (AUTHOR), Li, Jun² (AUTHOR), Zhang, Yao² (AUTHOR), Qi, Wenjing² (AUTHOR), Yan, Mingzhi² (AUTHOR), Wu, Jinzhi¹ (AUTHOR), Chan, Chikin¹ (AUTHOR), Pan, Xiaoben¹ (AUTHOR) xiaoben.pan@ghddi.org, Zhang, Wenbao² (AUTHOR) wenbaozhang2013@163.com

Publikováno v: Parasites & Vectors. 9/3/2024, Vol. 17 Issue 1, p1-15. 15p.