Structure determination, synthesis, and biological evaluation of a metabolite of the selective α1D adrenoceptor antagonist TAK-259

Autor: Sato, Ayumu, Sakauchi, Nobuki, Shirai, Junya, Furukawa, Hideki, Hara, Miki, Miwa, Katsuhiko, Fujita, Hisashi, Miyamoto, Maki, Tada, Norio, Kuno, Haruhiko, Kameoka, Nagako, Maezaki, Hironobu

Publikováno v: In Tetrahedron 13 October 2016 72(41):6334-6339

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors—Part 2

Autor: Yukawa, Tomoya, Fujimori, Ikuo, Kamei, Taku, Nakada, Yoshihisa, Sakauchi, Nobuki, Yamada, Masami, Ohba, Yusuke, Ueno, Hiroyuki, Takiguchi, Maiko, Kuno, Masako, Kamo, Izumi, Nakagawa, Hideyuki, Fujioka, Yasushi, Igari, Tomoko, Ishichi, Yuji, Tsukamoto, Tetsuya

Publikováno v: In Bioorganic & Medicinal Chemistry 15 July 2016 24(14):3207-3217

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Lead Optimization of Influenza Virus RNA Polymerase Inhibitors Targeting PA-PB1 Interaction.

Autor: Mizuta S; Center for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo, Nagasaki 852-8521, Japan., Otaki H; Center for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo, Nagasaki 852-8521, Japan., Ishikawa T; Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan., Makau JN; Center for Virus Research, Kenya Medical Research Institute, 54840-00200 Nairobi, Kenya., Yamaguchi T; Center for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo, Nagasaki 852-8521, Japan., Fujimoto T; Chemistry, Discovery Science, Axcelead Drug Discovery Partners, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan., Takakura N; Chemistry, Discovery Science, Axcelead Drug Discovery Partners, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan., Sakauchi N; Chemistry, Discovery Science, Axcelead Drug Discovery Partners, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan., Kitamura S; Chemistry, Discovery Science, Axcelead Drug Discovery Partners, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan., Nono H; School of Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan., Nishi R; School of Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan., Tanaka Y; Center for Medical Innovation, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan., Takeda K; Department of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo, Nagasaki 852-8521, Japan., Nishida N; Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan., Watanabe K; Department of Lifestyle Design, Faculty of Human Ecology, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami Ward, Hiroshima 731-0153, Japan.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jan 13; Vol. 65 (1), pp. 369-385. Date of Electronic Publication: 2021 Dec 14.