Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sakari Karhuvaara"'
Autor:
Antero Kallio, Tommi Nurminen, Eliisa Löyttyniemi, Markus Rosberg, Antti Virta, Rauno Mäkelä, Kaarlo Simojoki, Sakari Karhuvaara
Publikováno v:
Alcoholism: Clinical and Experimental Research. 31:1179-1187
Background: Clinical studies with opioid antagonists for treatment of problem drinking have mainly been conducted in specialized alcohol treatment centers, included structured psychosocial treatment, and have focused on maintaining abstinence after a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87175cddafc01cdb324a3d478349fdd5
https://doi.org/10.1111/j.1530-0277.2007.00401.x
https://doi.org/10.1111/j.1530-0277.2007.00401.x
Autor:
Helen M. Pettinati, Gantt P. Galloway, Sakari Karhuvaara, Michael J. Bohn, Henry R. Kranzler, Raymond F. Anton, Allen Zweben, Mary E. McCaul, James C. Garbutt, David R. Gastfriend, Robert M. Anthenelli, Bankole A. Johnson, Ihsan M. Salloum, Robert M. Swift, Antero Kallio
Publikováno v:
Journal of Clinical Psychopharmacology. 24:421-428
The opiate antagonist nalmefene has been shown in 2 single-site studies to reduce alcohol consumption and relapse drinking in alcohol-dependent individuals. This safety and preliminary multisite efficacy study evaluated 3 doses of nalmefene (5, 20, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76444205834dc051164784424e21babb
https://doi.org/10.1097/01.jcp.0000130555.63254.73
https://doi.org/10.1097/01.jcp.0000130555.63254.73
Publikováno v:
Anesthesiology. 89:574-584
Background Specific and selective alpha2-adrenergic drugs are widely exploited in veterinary anesthesiology. Because alpha2-agonists are also being introduced to human practice, the authors studied reversal of a clinically relevant dexmedetomidine do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb12d5ff7079759e2fcb6eb7b97a848
https://doi.org/10.1097/00000542-199809000-00005
https://doi.org/10.1097/00000542-199809000-00005
Publikováno v:
Life Sciences. 49:75-84
The usefulness of the plasma concentrations of two major metabolites of norepinephrine (NE), 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG), as indicators of neuronal NE release was investigated. The potent alpha 2-adreno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf216da76d30eb174c4ce90ca33d940
https://doi.org/10.1016/0024-3205(91)90581-u
https://doi.org/10.1016/0024-3205(91)90581-u
Autor:
Lotta Salminen, Sakari Karhuvaara, Mika Scheinin, Esko Iisalo, Risto Huupponen, Timo Kaila, Pekka Havula
Publikováno v:
Clinical Pharmacology and Therapeutics. 49:53-58
The concentration-effect relationship of 0.25 mg intravenous timolol with and without pretreatment with 100 mg quinidine was studied in six healthy young volunteers with a randomized, double-blind, crossover study design. Blockade of cardiac beta-adr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b30e980bd8b5b7eca844534e9b044e7
https://doi.org/10.1038/clpt.1991.10
https://doi.org/10.1038/clpt.1991.10
Publikováno v:
Psychoneuroendocrinology. 15:125-129
The role of alpha 2-adrenoceptors in the regulation of basal prolactin secretion was investigated in healthy male volunteers. Two independent, placebo-controlled, double-blind experiments were performed. In the first experiment, 50 micrograms dexmede
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5149b3ab709f6b40421cd812c7802466
https://doi.org/10.1016/0306-4530(90)90020-a
https://doi.org/10.1016/0306-4530(90)90020-a
Autor:
Sargo Aalto, Jarmo Hietala, Kjell Någren, Harry Scheinin, Vesa Oikonen, Nora Hagelberg, Sakari Karhuvaara, Kimmo Ingman, Auni Juhakoski, Antero Kallio
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 30(12)
The opioid antagonist nalmefene offers an alternative to traditional pharmacological treatments for alcoholism. The present study was designed to investigate the relationship between nalmefene plasma concentration and central mu-opioid receptor occup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff0763c845e2069483b1181e2a04f9d
https://pubmed.ncbi.nlm.nih.gov/15956985
https://pubmed.ncbi.nlm.nih.gov/15956985
Publikováno v:
Clinical pharmacology and therapeutics. 58(5)
Objective To evaluate the pharmacokinetics, systemic effects and clinical applicability of buccally administered atipamezole in healthy volunteers. Methods The study was carried out in two parts. In the first part, spray preparations of atipamezole h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89837fe36f62754a8632418b5a185b7
https://pubmed.ncbi.nlm.nih.gov/7586944
https://pubmed.ncbi.nlm.nih.gov/7586944
Autor:
Sakari Karhuvaara, Lauri Vuorilehto, Antero Kallio, Harry Scheinin, Klaus T. Olkkola, Markku Anttila, Mika Scheinin
Publikováno v:
Clinical pharmacology and therapeutics. 52(5)
The pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine--a novel alpha 2-adrenergic receptor agonist under development for preanesthetic use--were studied in healthy male volunteers. Single intramuscular doses of dexmedetomidine (0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12b576d3952ba4d185fce3217d1388a
https://pubmed.ncbi.nlm.nih.gov/1358496
https://pubmed.ncbi.nlm.nih.gov/1358496
1. The ability of atipamezole, a specific and selective alpha 2-adrenoceptor antagonist, to reverse the pharmacological effects induced by the alpha 2-adrenoceptor agonist dexmedetomidine was studied in six healthy male volunteers. Each volunteer rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59c9e468440c133efce3fc5dd9aa578
https://europepmc.org/articles/PMC1368383/
https://europepmc.org/articles/PMC1368383/
