Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sakae Ikeda"'
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Aging is the most significant risk factor for age-related diseases in general, which is true for age-related diseases in the eye including age-related macular degeneration (AMD). Therefore, in order to identify potential therapeutic targets for these
Externí odkaz:
https://doaj.org/article/88e6ae25510340a1bda227155eb5c0ac
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Autor:
Michael Landowski, Vijesh J. Bhute, Samuel Grindel, Zachary Haugstad, Yeboah K. Gyening, Madison Tytanic, Richard S. Brush, Lucas J. Moyer, David W. Nelson, Christopher R. Davis, Chi-Liang Eric Yen, Sakae Ikeda, Martin-Paul Agbaga, Akihiro Ikeda
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Lipid analysis of transmembrane protein 135 (TMEM135) mutant mice reveals robust decreases in docosahexaenoic acid (DHA), indicating a function of TMEM135 on the export of DHA from peroxisomes that is important for maintaining lipid metabolism.
Externí odkaz:
https://doaj.org/article/aac097ba34414892882b668cb0412247
Autor:
Michael Landowski, Vijesh J. Bhute, Tetsuya Takimoto, Samuel Grindel, Pawan K. Shahi, Bikash R. Pattnaik, Sakae Ikeda, Akihiro Ikeda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Aging is a significant factor in the development of age-related diseases but how aging disrupts cellular homeostasis to cause age-related retinal disease is unknown. Here, we further our studies on transmembrane protein 135 (Tmem135), a gene
Externí odkaz:
https://doaj.org/article/d633aa25577040809a8ae0d6a88ae590
Autor:
Sarah Aileen Lewis, Tetsuya Takimoto, Shima Mehrvar, Hitoshi Higuchi, Anna-Lisa Doebley, Giangela Stokes, Nader Sheibani, Sakae Ikeda, Mahsa Ranji, Akihiro Ikeda
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201986 (2018)
Tissues with high-energy demand including the heart are rich in the energy-producing organelles, mitochondria, and sensitive to mitochondrial dysfunction. While alterations in mitochondrial function are increasingly recognized in cardiovascular disea
Externí odkaz:
https://doaj.org/article/ff1953c15c2c46ea8bd53a439651a14a
Autor:
Wei-Hua Lee, Hitoshi Higuchi, Sakae Ikeda, Erica L Macke, Tetsuya Takimoto, Bikash R Pattnaik, Che Liu, Li-Fang Chu, Sandra M Siepka, Kathleen J Krentz, C Dustin Rubinstein, Robert F Kalejta, James A Thomson, Robert F Mullins, Joseph S Takahashi, Lawrence H Pinto, Akihiro Ikeda
Publikováno v:
eLife, Vol 5 (2016)
While the aging process is central to the pathogenesis of age-dependent diseases, it is poorly understood at the molecular level. We identified a mouse mutant with accelerated aging in the retina as well as pathologies observed in age-dependent retin
Externí odkaz:
https://doaj.org/article/22ceabf2f14e4691973e8b4718595d1f
Autor:
Xinjie Xu, Rajendra Kedlaya, Hitoshi Higuchi, Sakae Ikeda, Monica J Justice, Vijayasaradhi Setaluri, Akihiro Ikeda
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000956 (2010)
Intracellular trafficking is critical for delivering molecules and organelles to their proper destinations to carry out normal cellular functions. Disruption of intracellular trafficking has been implicated in the pathogenesis of various neurodegener
Externí odkaz:
https://doaj.org/article/d1a9265ca97d42d9a4861fb22108929f
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2701 (2008)
Destrin (DSTN) is a member of the ADF/cofilin family of proteins and is an important regulator of actin dynamics. The primary function of destrin is to depolymerize filamentous actin into its monomeric form and promote filament severing. While progre
Externí odkaz:
https://doaj.org/article/abdf08015c6c47f3a39a2f220a1538c6
Autor:
Akihiro Ikeda, Catherine Bowes Rickman, Sakae Ikeda, Ying Hao, Samuel Grindel, Michael Landowski
Publikováno v:
Journal of Visualized Experiments.
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Autor:
Michael Landowski, Vijesh J. Bhute, Samuel Grindel, Zachary Haugstad, Yeboah K. Gyening, Madison Tytanic, Richard S. Brush, Lucas J. Moyer, David W. Nelson, Christopher R. Davis, Chi-Liang Eric Yen, Sakae Ikeda, Martin-Paul Agbaga, Akihiro Ikeda
Publikováno v:
Communications biology. 6(1)
Transmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular function for TMEM135 in lipid metabolism has been identified. In this study, we performed a lipid analys
Publikováno v:
Experimental Biology and Medicine. 245:1571-1583
Mitochondria are dynamic organelles that undergo fission and fusion. While they are essential for cellular metabolism, the effect of dysregulated mitochondrial dynamics on cellular metabolism is not fully understood. We previously found that transmem