Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sajjan Rajpoot"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The role of TIRAP (toll/interleukin-1 receptor (TIR) domain-containing adapter protein) in macrophage inflammatory signalling has been significantly evolved since its discovery in 2001 due to its dynamic nature and subcellular localization t
Externí odkaz:
https://doaj.org/article/cea9032c9bd94da9b3d98d4e1f30516f
Autor:
Yining Wang, Pengfei Li, Sajjan Rajpoot, Uzma Saqib, Peifa Yu, Yunlong Li, Yang Li, Zhongren Ma, Mirza S. Baig, Qiuwei Pan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Human coronavirus NL63 (HCoV-NL63) mainly affects young children and immunocompromised patients, causing morbidity and mortality in a subset of patients. Since no specific treatment is available, this study aims to explore the anti-SARS-CoV-
Externí odkaz:
https://doaj.org/article/da147927209f40efb13ba665c6af183b
Autor:
Kundan Solanki, Sajjan Rajpoot, Evgeny E. Bezsonov, Alexander N. Orekhov, Rohit Saluja, Anita Wary, Cassondra Axen, Kishore Wary, Mirza S. Baig
Publikováno v:
PeerJ, Vol 10, p e13651 (2022)
The nitric oxide synthases (NOS; EC 1.14.13.39) use L-arginine as a substrate to produce nitric oxide (NO) as a by-product in the tissue microenvironment. NOS1 represents the predominant NO-producing enzyme highly enriched in the brain and known to m
Externí odkaz:
https://doaj.org/article/7581a9b1ac83482bb68978991cec3a7a
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 9-18 (2021)
With the rapid growth of the COVID-19 (coronavirus disease 2019) pandemic across the globe, therapeutic attention must be directed to fight the novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). However, developing new antiviral drug
Externí odkaz:
https://doaj.org/article/75edb8e3448748558734b9b288cebd67
Publikováno v:
Drugs in R&D, Vol 20, Iss 3, Pp 161-169 (2020)
Abstract Background and objective Coronavirus disease (COVID-19) is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the incessant spread of the disease with substantial morbidity and mortality rates,
Externí odkaz:
https://doaj.org/article/1d3a57c9287c49a99ed61918a150cba3
Autor:
Tomokazu Ohishi, Takayuki Hishiki, Mirza S Baig, Sajjan Rajpoot, Uzma Saqib, Tomohiko Takasaki, Yukihiko Hara
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271112 (2022)
The outbreak of the coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 triggered a global pandemic where control is needed through therapeutic and preventive interventions. This study aims to identify natural compo
Externí odkaz:
https://doaj.org/article/3cffaba36c4548278f23bac852708692
Autor:
Sajjan Rajpoot, Kishore K. Wary, Rachel Ibbott, Dongfang Liu, Uzma Saqib, Teresa L. M. Thurston, Mirza S. Baig
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Toll-interleukin-1 Receptor (TIR) domain-containing adaptor protein (TIRAP) represents a key intracellular signalling molecule regulating diverse immune responses. Its capacity to function as an adaptor molecule has been widely investigated in re
Externí odkaz:
https://doaj.org/article/542f16155e9c4ca79f20441c409889c8
Autor:
Sajjan Rajpoot, Ashutosh Kumar, Vadim Gaponenko, Teresa LM Thurston, Dolly Mehta, Syed M Faisal, Kam YJ Zhang, Hem C Jha, Gajanan N Darwhekar, Mirza S Baig
Publikováno v:
Future Medicinal Chemistry. 15:533-554
Background: Sepsis is a syndrome due to microbial infection causing impaired multiorgan function. Its underlying cause is immune dysfunction and macrophages play an essential role. Methods: TIRAP interaction with PKCδ in macrophage was studied, reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::653af0bd334d1f7a8c87d74b6d961a7d
https://doi.org/10.4155/fmc-2022-0260
https://doi.org/10.4155/fmc-2022-0260
Autor:
Kundan Solanki, Sajjan Rajpoot, Ashutosh Kumar, Kam Y J Zhang, Tomokazu Ohishi, Nik Hirani, Khandu Wadhonkar, Pramod Patidar, Qiuwei Pan, Mirza S Baig
Publikováno v:
Future Virology, 17(10), 723-732. Future Medicine Ltd.
Aim: Mutations in the SARS-CoV-2 spike (S) protein have dramatically changed the transmissibility and pathogenicity of the virus. Therefore, we studied the binding affinity of Omicron spike-receptor binding domain (S-RBD) with human ACE2 receptor. Ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3f6748f1325c70982025f2f57c8cce
https://doi.org/10.2217/fvl-2022-0003
https://doi.org/10.2217/fvl-2022-0003
Autor:
Mirza S. Baig, Ashutosh Kumar, Tomokazu Ohishi, Qiuwei Pan, Sajjan Rajpoot, Sreeparna Banerjee, Kam Y. J. Zhang
Publikováno v:
Drugs in R&D
Drugs in R and D, 21(3), 273-283. Adis
Drugs in R and D, 21(3), 273-283. Adis
Background and Objective Coronavirus disease 2019 is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first detected in December 2019 and has since been declared a pandemic causing millions of dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1d96c78d81b1ea632995a6a53f6bfe
https://doi.org/10.1007/s40268-021-00357-0
https://doi.org/10.1007/s40268-021-00357-0