Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Sajjad Karim"'
Autor:
Mahmood Rasool, Peter Natesan Pushparaj, Absarul Haque, Ayat Mohammed Shorbaji, Loubna Siraj Mira, Sherin Bakhashab, Mohamed Nabil Alama, Muhammad Farooq, Sajjad Karim, Lars Allan Larsen
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37177- (2024)
Background & aim: Congenital heart disease (CHD) is the most common cause of non-infectious deaths in infants worldwide. However, the molecular mechanisms underlying CHD remain unclear. Approximately 30 % of the causes are believed to be genetic muta
Externí odkaz:
https://doaj.org/article/457a87b4a9304fe2848619c2131c0d6d
Autor:
Adel Abuzenadah, Nofe Alganmi, Raghad AlQurashi, Esraa Hawsa, Abdullah AlOtibi, Abdulrahman Hummadi, Ahmed Ali Nahari, Somaya AlZelaye, Nasser R. Aljuhani, Manal Al-Attas, Heba Abusamra, Shereen Turkistany, Sajjad Karim, Zeenat Mirza, Mohammed Al-Qahtani, Adeel Chaudhary, Mariam M. Al Eissa
Publikováno v:
Journal of Epidemiology and Global Health, Vol 14, Iss 1, Pp 162-168 (2024)
Abstract Background Lipodystrophy is a relatively rare, complex disease characterised by a deficiency of adipose tissue and can present as either generalised lipodystrophy (GLD) or partial lipodystrophy (PLD). The prevalence of this disease varies by
Externí odkaz:
https://doaj.org/article/77f892a1ac48446da3a7bc8d65a5ff3d
Autor:
Mahmood Rasool, Sajjad Karim, Absarul Haque, Mohammed Alharthi, Adeel G Chaudhary, Peter Natesan Pushparaj
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 9, Pp 103415- (2024)
Background: Colorectal cancer (CRC) liver metastasis (CRLM) is a clinical challenge, and optimizing treatment strategies is crucial for improving patient outcomes. This study aimed to identify gene expression signatures associated with CRLM for early
Externí odkaz:
https://doaj.org/article/22de55fa872c4767a0178760a12c01b2
Autor:
Sajjad Karim, Md Shahid Iqbal, Fadwa Aljoud, Najla Ali Alburae, Zoya Nisar, Nofe Alganmi, Haneen Banjar, Zeenat Mirza
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 5, Pp 103161- (2024)
Background: Genetic alterations in the perilipin (PLIN) family genes (PLIN1 to PLIN5) were infrequent in breast cancer (BC) where enhanced levels of PLIN1, PLIN3-5 were observed in the luminal A and luminal B subgroups, whereas increased PLIN2 expres
Externí odkaz:
https://doaj.org/article/46b53bf3e8ca4b499c7072c928c56321
Autor:
Nofe Alganmi, Arwa Bashanfar, Reem Alotaibi, Haneen Banjar, Sajjad Karim, Zeenat Mirza, Heba Abusamra, Manal Al-Attas, Shereen Turkistany, Adel Abuzenadah
Publikováno v:
PeerJ Computer Science, Vol 10, p e1942 (2024)
Breast and ovarian cancers are prevalent worldwide, with genetic factors such as BRCA1 and BRCA2 mutations playing a significant role. However, not all patients carry these mutations, making it challenging to identify risk factors. Researchers have t
Externí odkaz:
https://doaj.org/article/40d7cf44379745d9830da5fd454a2cd4
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3419 (2024)
Acute myeloid leukemia (AML) is hallmarked by the clonal proliferation of myeloid blasts. Mutations that result in the constitutive activation of the fms-like tyrosine kinase 3 (FLT3) gene, coding for a class III receptor tyrosine kinase, are signifi
Externí odkaz:
https://doaj.org/article/c2927cc44c8b459abae2500ba4dc1a60
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A method, PhyloSignare, is presented to infer mutational signatures along a tumour evolutionary tree and is used to analyse somatic genomic variations in 61 lung cancer patients, providing insights into tumour evolution.
Externí odkaz:
https://doaj.org/article/d5d4368a35e74f418b09bc109f1131fe
Autor:
Sajjad Karim, Md Shahid Iqbal, Nesar Ahmad, Md Shahid Ansari, Zeenat Mirza, Adnan Merdad, Saddig D. Jastaniah, Sudhir Kumar
Publikováno v:
Journal of King Saud University: Science, Vol 35, Iss 1, Pp 102447- (2023)
Objective: Breast Cancer (BC) is one of the deadliest diseases in women, causing thousands of deaths annually despite the advent of high-throughput genomic platforms in the recent past. Microarray-based gene expression profiling with different statis
Externí odkaz:
https://doaj.org/article/c90896c2167e4d5fb46ff4661012892f
Autor:
Hans-Juergen Schulten, Fatima Al-Adwani, Haneen A. Bin Saddeq, Heba Alkhatabi, Nofe Alganmi, Sajjad Karim, Deema Hussein, Khalid B. Al-Ghamdi, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed H. Al-Qahtani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are oncogenic drivers to a variable extent in several tumors, including gliomas, acute myeloid leukemia (AML), cholangiocarcinoma, melanoma, and thyroid carcinoma. The pathobiological e
Externí odkaz:
https://doaj.org/article/67296b160a7742238af9ec1062355f36
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6045-6049 (2021)
Colorectal cancer (CRC) is one of the leading causes of death in Saudi Arabia. CRC mostly affects older age groups, but now a days it also appears frequently at a young age. However, the complete genetic etiology of CRC remains unknown. To identify t
Externí odkaz:
https://doaj.org/article/4dc1149fdeff40b29c2bfbddf460cb71