Výsledky vyhledávání - "Sajeewa W Dewage"

Akademický článek

Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain.

Autor: Robin Bonomi, Uday Mukhopadhyay, Aleksandr Shavrin, Hsien-Hsien Yeh, Anjoy Majhi, Sajeewa W Dewage, Amer Najjar, Xin Lu, G Andrés Cisneros, William P Tong, Mian M Alauddin, Ren-Shuan Liu, Thomas J Mangner, Nashaat Turkman, Juri G Gelovani

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133512 (2015)

Histone deacetylases (HDAC's) became increasingly important targets for therapy of various diseases, resulting in a pressing need to develop HDAC class- and isoform-selective inhibitors. Class IIa deacetylases possess only minimal deacetylase activit

Externí odkaz: https://doaj.org/article/3ab80ca33b63401587d670592377c586

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Structure-guided DNA–DNA attraction mediated by divalent cations

Autor: Xiangyun Qiu, Seung Heo, Raju Timsina, Amit Srivastava, Serdal Kirmizialtin, Sajeewa W. Dewage

Publikováno v: Nucleic Acids Research

Probing the role of surface structure in electrostatic interactions, we report the first observation of sequence-dependent dsDNA condensation by divalent alkaline earth metal cations. Disparate behaviors were found between two repeating sequences wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a53b51b25386f6d8658a6d7d4382c66
http://europepmc.org/articles/PMC7367160

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Structure-guided DNA-DNA attraction mediated by divalent cations

Autor: Seung Heo, Xiangyun Qiu, Raju Timsina, Amit Srivastava, Sajeewa W. Dewage, Serdal Kirmizialtin

Probing the role of surface structure in electrostatic interactions, we report the first observation of sequence-dependent dsDNA condensation by divalent alkali cations. Disparate behaviors were found between two repeating sequences with 100% AT cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46052d136271df8fb44d042a56f9f71
https://doi.org/10.1101/2020.02.27.968982

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Calix[4]arene-Based Porous Organic Nanosheets

Autor: Kyriaki Polychronopoulou, Ali Trabolsi, Ilma Jahović, Seema Sharma, John Carl Olsen, Ramesh Jagannathan, Zouhair Asfari, Serdal Kirmizialtin, Dinesh K. Shetty, Tina Skorjanc, Sajeewa W. Dewage, Jésus Raya, Dong Suk Han

Publikováno v: ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2018, 10 (20), pp.17359-17365. ⟨10.1021/acsami.8b03800⟩

Copyright © 2018 American Chemical Society. Calixarenes are a common motif in supramolecular chemistry but have rarely been incorporated in structurally well-defined covalent 2D materials. Such a task is challenging, especially without a template, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8676b48476cb916cf62dfa4d0859838d
https://doi.org/10.1021/acsami.8b03800

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Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis

Autor: Sajeewa W. Dewage, Allan H. Pang, Oleg V. Tsodikov, Tapan Biswas, S. Barnard-Britson, G.A Cisneros, A.C. Pratt

Publikováno v: Journal of Structural Biology. 192:76-87

Family I inorganic pyrophosphatases (PPiases) are ubiquitous enzymes that are critical for phosphate metabolism in all domains of life. The detailed catalytic mechanism of these enzymes, including the identity of the general base, is not fully unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f6bc780072cd700b320490417423a2
https://doi.org/10.1016/j.jsb.2015.08.010

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Computational Analysis of Ammonia Transfer Along Two Intramolecular Tunnels in Staphylococcus aureus Glutamine-Dependent Amidotransferase (GatCAB)

Autor: G. Andrés Cisneros, Sajeewa W. Dewage

Publikováno v: The Journal of Physical Chemistry B. 119:3669-3677

Most bacteria and all archaea misacylate the tRNAs corresponding to Asn and Gln with Asp and Glu (Asp-tRNA(Asn) and Glu-tRNA(Gln)).The GatCAB enzyme of most bacteria converts misacylated Glu-tRNA(Gln) to Gln-tRNA(Gln) in order to enable the incorpora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5a0f78616ad5c0284e17a36ad4ee8a
https://doi.org/10.1021/jp5123568

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Characterization of tunnel mutants reveals a catalytic step in ammonia delivery by an aminoacyl-tRNA amidotransferase

Autor: Udumbara M. Rathnayake, Tamara L. Hendrickson, Whitney N. Wood, G. Andrés Cisneros, Anthony J. Veltri, Sajeewa W. Dewage, Liangjun Zhao

Publikováno v: FEBS letters. 590(18)

The Helicobacter pylori Asp-tRNA(A) (sn) /Glu-tRNA(G) (ln) amidotransferase (GatCAB) utilizes an uncommonly hydrophilic, ~ 40 A ammonia tunnel for ammonia/ammonium transport between isolated active sites. Hydrophilicity of this tunnel requires a dist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2961d7c4c435a8dad01b5806487937
https://pubmed.ncbi.nlm.nih.gov/27500385

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The kinase activity of the Helicobacter pylori Asp-tRNAAsn/Glu-tRNAGln amidotransferase is sensitive to distal mutations in its putative ammonia tunnel

Autor: Liangjun Zhao, Nilesh Joshi, Gayathri N. Silva, Shirin Fatma, Keng Ming Chang, Tamara L. Hendrickson, Michael J. Bell, Sajeewa W. Dewage, G. Andrés Cisneros

The Helicobacter pylori (Hp) Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase (AdT) plays important roles in indirect aminoacylation and translational fidelity. AdT has two active sites, in two separate subunits. Kinetic studies have suggested that inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1104789717e1db81750a6e91d1539d4a
https://europepmc.org/articles/PMC3604897/

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Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain

Autor: G. Andrés Cisneros, Thomas J. Mangner, Aleksandr Shavrin, Juri G. Gelovani, Nashaat Turkman, Hsien Hsien Yeh, William P. Tong, Anjoy Majhi, Mian M. Alauddin, Ren Shuan Liu, Xin Lu, Amer Najjar, Uday Mukhopadhyay, Sajeewa W. Dewage, Robin E. Bonomi

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0133512 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cdf3a9932b189ec4431935abcb266a
https://doi.org/10.1371/journal.pone.0133512

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