Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sajeev Kohli"'
Autor:
Katarina Kulhankova, Soumba Traore, Xue Cheng, Hadrien Benk-Fortin, Stéphanie Hallée, Mario Harvey, Joannie Roberge, Frédéric Couture, Sajeev Kohli, Thomas J. Gross, David K. Meyerholz, Garrett R. Rettig, Bernice Thommandru, Gavin Kurgan, Christine Wohlford-Lenane, Dennis J. Hartigan-O’Connor, Bradley P. Yates, Gregory A. Newby, David R. Liu, Alice F. Tarantal, David Guay, Paul B. McCray
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Gene editing strategies for cystic fibrosis are challenged by the complex barrier properties of airway epithelia. We previously reported that the amphiphilic S10 shuttle peptide non-covalently combined with CRISPR-associated (Cas) ribonucleo
Externí odkaz:
https://doaj.org/article/8ac54f1857804245a0069d9ef38b1f91
Autor:
Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang, Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Leber congenital amaurosis is caused by mutations in RPE65 and leads to retinal degeneration in children. Here, the authors show that in vivo base editing can prolong the survival of cone photoreceptors and rescue their function in a mouse model of t
Externí odkaz:
https://doaj.org/article/ffc071797e4f4fa694375352a34ae7c4
Autor:
Daniel Reichart, Gregory A. Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M. Gorham, Justin J. Curran, Aditya Raguram, Daniel M. DeLaughter, David A. Conner, Júlia D. C. Marsiglia, Sajeev Kohli, Lukas Chmatal, David C. Page, Nerea Zabaleta, Luk Vandenberghe, David R. Liu, Jonathan G. Seidman, Christine Seidman
Publikováno v:
Nature Medicine. 29:412-421
Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart failure and sudden cardiac death. In this study, we assessed two differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40c249da070ec355df913c8d97b81c9
https://doi.org/10.1038/s41591-022-02190-7
https://doi.org/10.1038/s41591-022-02190-7
Autor:
Florence Borot, Olivier Humbert, Gregory A Newby, Emily Fields, Sajeev Kohli, Stefan Radtke, George S. Laszlo, Thiyagaraj Mayuranathan, Abdullah Mahmood Ali, Mitchell J. Weiss, Jonathan S. Yen, Roland B. Walter, David R. Liu, Siddhartha Mukherjee, Hans-Peter Kiem
Publikováno v:
bioRxiv
On-target toxicity to normal cells is a major safety concern with targeted immune and gene therapies. Here, we developed a base editing (BE) approach exploiting a naturally occurring CD33 single nucleotide polymorphism leading to removal of full-leng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efe9077b262227a9035dab3e8b8664f
https://europepmc.org/articles/PMC9980058/
https://europepmc.org/articles/PMC9980058/
Autor:
Jack C. Boettcher, Christie Hung, Sajeev Kohli, Daniel S. Engebretson, Daniel R. Morphet, Brandon M. Campbell, Dilek K. Dogutan, Daniel G. Nocera
Publikováno v:
The journal of physical chemistry letters. 13(30)
Two electrons in two orbitals give rise to four states. When the orbitals are weakly coupled as in the case for the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65342b4d107df7f0c3a985fdb701b77
https://pubmed.ncbi.nlm.nih.gov/35877177
https://pubmed.ncbi.nlm.nih.gov/35877177
Autor:
Elliot H, Choi, Susie, Suh, Andrzej T, Foik, Henri, Leinonen, Gregory A, Newby, Xin D, Gao, Samagya, Banskota, Thanh, Hoang, Samuel W, Du, Zhiqian, Dong, Aditya, Raguram, Sajeev, Kohli, Seth, Blackshaw, David C, Lyon, David R, Liu, Krzysztof, Palczewski
Publikováno v:
Nature communications. 13(1)
Leber congenital amaurosis (LCA) is the most common cause of inherited retinal degeneration in children. LCA patients with RPE65 mutations show accelerated cone photoreceptor dysfunction and death, resulting in early visual impairment. It is therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::026b1a88b93bea4c96eb1dbab887b5f2
https://pubmed.ncbi.nlm.nih.gov/35383196
https://pubmed.ncbi.nlm.nih.gov/35383196