Platelet–Eosinophil Interactions As a Potential Therapeutic Target in Allergic Inflammation and Asthma

Autor: Sajeel A. Shah, Clive P. Page, Simon C. Pitchford

Publikováno v: Frontiers in Medicine, Vol 4 (2017)

The importance of platelet activation during hemostasis is well understood. An understanding of these mechanisms has led to the use of several classes of anti-platelet drugs to inhibit aggregation for the prevention of thrombi during cardiovascular d

Externí odkaz: https://doaj.org/article/df8bb6e0b43b4044b9d0961349c6f98f

Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3

Autor: Christopher Corrigan, Alan L. James, Sajeel A. Shah, Yanira Riffo-Vasquez, John G. Elliot, Clive P. Page, Zainab Mohamed, Simon C. Pitchford, Varsha Kanabar, Janis K. Shute, Simon J. Cleary

Publikováno v: Shah, S A, Kanabar, V, Riffo-Vasquez, Y, Mohamed, Z, Cleary, S J, Corrigan, C, James, A L, Elliott, J G, Shute, J K, Page, C P & Pitchford, S C 2021, ' Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3 ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 5, pp. 557–568 . https://doi.org/10.1165/rcmb.2020-0425OC
American Journal of Respiratory Cell and Molecular Biology

Platelet activation and pulmonary recruitment occur in patients with asthma and in animal models of allergic asthma, in which leukocyte infiltration, airway remodeling, and hyperresponsiveness are suppressed by experimental platelet depletion. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec64117fa68f54360c906d25df93a078
https://kclpure.kcl.ac.uk/ws/files/155174783/rcmb.2020_0425oc.pdf

A dichotomy in platelet activation: Evidence of different functional platelet responses to inflammatory versus haemostatic stimuli

Autor: Stefania Momi, Richard T. Amison, Simon C. Pitchford, Clive P. Page, Eleonora Petito, Elisa Piselli, Sajeel A. Shah, Paolo Gresele

Publikováno v: Petito, E, Amison, R T, Piselli, E, Shah, S, Momi, S, Pitchford, S C, Gresele, P & Page, C P 2018, ' A dichotomy in platelet activation : Evidence of different functional platelet responses to inflammatory versus haemostatic stimuli ', Thrombosis Research . https://doi.org/10.1016/j.thromres.2018.10.019

Introduction Platelets participate in inflammatory disorders through a variety of different functional responses, including chemotaxis, platelet-leukocyte complex formation and facilitation of leukocyte recruitment that are thought to be distinct fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fd9461414f648b014b35ffb0b1cbc9
http://hdl.handle.net/11391/1448558

Platelet–Eosinophil Interactions As a Potential Therapeutic Target in Allergic Inflammation and Asthma

Autor: Clive P. Page, Sajeel A. Shah, Simon C. Pitchford

Publikováno v: Frontiers in Medicine
Frontiers in Medicine, Vol 4 (2017)

The importance of platelet activation during haemostasis is well understood. An understanding of these mechanisms has led to the use of several classes of anti-platelet drugs to inhibit aggregation for the prevention of thrombi during cardiovascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6753ebe56a7a706f31af4ad8fc79e0f1
https://doi.org/10.3389/fmed.2017.00129