Real world evidence (RWE) – a disruptive innovation or the quiet evolution of medical evidence generation? [version 2; referees: 2 approved]

Autor: Sajan Khosla, Robert White, Jesús Medina, Mario Ouwens, Cathy Emmas, Tim Koder, Gary Male, Sandra Leonard

Publikováno v: F1000Research, Vol 7 (2018)

Stakeholders in healthcare are increasingly turning to real world evidence (RWE) to inform their decisions, alongside evidence from randomized controlled trials. RWE is generated by analysing data gathered from routine clinical practice, and can be u

Externí odkaz: https://doaj.org/article/6f9c850b2651466e86380ad034be3626

The Aetion Coalition to Advance Real-World Evidence through Randomized Controlled Trial Emulation Initiative: Oncology

Autor: David Merola, Ulka Campbell, Nileesa Gautam, Alexa Rubens, Sebastian Schneeweiss, Shirley V. Wang, Gillis Carrigan, Victoria Chia, Osayi E. Ovbiosa, Simone Pinheiro, Amanda Bruno, Xiaolong Jiao, Mark Stewart, Rachele Hendricks‐Sturrup, Carla Rodriguez‐Watson, Sajan Khosla, Yiduo Zhang, Mothaffar Rimawi, Jenny Huang, Aliki Taylor, Lauren Becnel, Lynn McRoy, Joy Eckert, Benjamin Taylor

Publikováno v: Clinical pharmacology and therapeutics.

Legislative and technological advancements over the past decade have given rise to the proliferation of healthcare data generated from routine clinical practice, often referred to as real-world data (RWD). These data have piqued the interest of healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de343d2c72175b8e0f59a69af7f1b545
https://pubmed.ncbi.nlm.nih.gov/36408668

Strengthening pharma's contract with society: the value of trusted partnerships between pharma and healthcare facilitated by real-world data

Autor: Jonathan M Plumb, Mark J Nagy, Robert J. LoCasale, Donald Yin, Sajan Khosla, Ben Gutierrez, Mette Hammer, Chris L Pashos, Michael J Seewald, Maurille Feudjo Tepie, Johan Liwing

Publikováno v: Journal of Comparative Effectiveness Research. 9:155-159

This White Paper is authored by 11 industry real-world evidence (RWE) experts, with support from IQVIA, as part of the ‘RWE Leadership Forum’: a group of industry leaders who come together as noncompetitive partners to understand and respond to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141a5cf309c5fbed0fc44d245be4f1af
https://doi.org/10.2217/cer-2019-0183

Clinical trials, real-world evidence, and digital medicine

Autor: Gabriela Feldberg, Mishal Patel, Jim Weatherall, Richard Dearden, Sajan Khosla, Glynn Dennis, Thomas E. White, Khader Shameer, Faisal Khan

The development of new medicines through the clinical trials process offers countless opportunities for the application of approaches such as those offered by artificial intelligence and machine learning. Broadly speaking, the application of these te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55cd71e4c658118f0970ff88efc44dfa
https://doi.org/10.1016/b978-0-12-820045-2.00011-8

Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: A multinational network cohort study

Autor: Edward Burn, Anthony G. Sena, David Vizcaya, Marcel de Wilde, Peter R. Rijnbeek, Benjamin Skov Kaas-Hansen, Albert Prats-Uribe, Haini Wen, Osaid Alser, Laura Hester, Jill Hardin, Mees Mosseveld, Carlos Areia, H Morgan-Stewart, Gowtham A. Rao, Patrick B. Ryan, Thamir M. Alshammari, Jennifer C E Lane, Kristin Kostka, Juan M. Banda, George Hripcsak, Kristine E. Lynch, Christian G. Reich, James Weaver, Paula Casajust, Sajan Khosla, Kristina Fišter, Danielle Newby, Rae Woong Park, Fredrik Nyberg, Simon Lovestone, Maria Tereza Fernandes Abrahão, Seng Chan You, Patricia Biedermann, Matthew E. Spotnitz, Spyros Kolovos, Daniel Prieto-Alhambra, Daniel R. Morales, Marc A. Suchard, Vignesh Subbian, Paras P. Mehta, Anna Ostropolets, Heba Alghoul, Junqing Xie, Azza Shoaibi, Talita Duarte-Salles, Rupa Makadia, Lin Zhang

Publikováno v: Rheumatology (United Kingdom), 60(7), 3222-3234. Oxford University Press
Rheumatology
Lane, J C E, Weaver, J, Kostka, K, Duarte-Salles, T, Abrahao, M T F, Alghoul, H, Alser, O, Alshammari, T M, Areia, C, Biedermann, P, Banda, J M, Burn, E, Casajust, P, Fister, K, Hardin, J, Hester, L, Hripcsak, G, Kaas-Hansen, B S, Khosla, S, Kolovos, S, Lynch, K E, Makadia, R, Mehta, P P, Morales, D R, Morgan-Stewart, H, Mosseveld, M, Newby, D, Nyberg, F, Ostropolets, A, Woong Park, R, Prats-Uribe, A, Rao, G A, Reich, C, Rijnbeek, P, Sena, A G, Shoaibi, A, Spotnitz, M, Vignesh, S, Suchard, M A, Vizcaya, D, Wen, H, de Wilde, M, Xie, J, You, S C, Zhang, L, Lovestone, S, Ryan, P, Prieto-Alhambra, D & OHDSI-COVID-19 consortium 2021, ' Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis : a multinational network cohort study ', Rheumatology, vol. 60, no. 7, pp. 3222–3234 . https://doi.org/10.1093/rheumatology/keaa771
Rheumatology (Oxford, England)

Author(s): Lane, Jennifer CE; Weaver, James; Kostka, Kristin; Duarte-Salles, Talita; Abrahao, Maria Tereza F; Alghoul, Heba; Alser, Osaid; Alshammari, Thamir M; Areia, Carlos; Biedermann, Patricia; Banda, Juan M; Burn, Edward; Casajust, Paula; Fister

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ab5739932161460702f3f42560f16c
https://pure.eur.nl/en/publications/0242de45-3071-467f-9b0f-aa186afe0090