Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Sajal Sen"'
Autor:
Yunjie Xu, Yingwei Wang, Jusung An, Adam C. Sedgwick, Mingle Li, Jianlei Xie, Weibin Hu, Jianlong Kang, Sajal Sen, Axel Steinbrueck, Bin Zhang, Lijun Qiao, Swelm Wageh, Jonathan F. Arambula, Liping Liu, Han Zhang, Jonathan L. Sessler, Jong Seung Kim
Publikováno v:
Bioactive Materials, Vol 14, Iss , Pp 76-85 (2022)
An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target. Unfortunately, current iron-based t
Externí odkaz:
https://doaj.org/article/d782771aa4954029b1ade144caa4c826
Autor:
Axel Steinbrueck, Adam C. Sedgwick, Suh-Mi Hwang, Sajal Sen, Michael Y. Zhao, Dan-Ying Huang, Daniel M. Knoll, Yu-Ying Wang, Jonathan L. Sessler
Publikováno v:
Chemosensors, Vol 9, Iss 4, p 68 (2021)
Here, we report that ExSO3H, a synthetically accessible, water-soluble, non-toxic derivative of the clinical iron chelator deferasirox, acts as a colorimetric chemosensor that permits the detection and quantification of Fe3+ in aqueous samples at pH
Externí odkaz:
https://doaj.org/article/70c03152a38e43829d4ea61007b259b5
Autor:
Xi-Le Hu, Adam C. Sedgwick, Daniel N. Mangel, Ying Shang, Axel Steinbrueck, Kai-Cheng Yan, Ling Zhu, Dylan W. Snelson, Sajal Sen, Calvin V. Chau, Gabriel Juarez, Vincent M. Lynch, Xiao-Peng He, Jonathan L. Sessler
Publikováno v:
Journal of the American Chemical Society. 144:7382-7390
Deferasirox, an FDA-approved iron chelator, has gained increasing attention for use in anticancer and antimicrobial applications. Recent efforts by our group led to the identification of this core as an easy-to-visualize aggregation-induced emission
Autor:
Calvin V. Chau, Sajal Sen, Adam C. Sedgwick, Philip A. Gale, G. Dan Pantos, Sung Kuk Kim, Jung Su Park, Elisa Tomat, Jonathan F. Arambula, Anne E.V. Gorden, Hiroyuki Furuta
Publikováno v:
Chem. 8:587-598
Autor:
Sajal Sen, Miae Won, Matthew S. Levine, Yuvin Noh, Adam C. Sedgwick, Jong Seung Kim, Jonathan L. Sessler, Jonathan F. Arambula
Publikováno v:
Chem Soc Rev
Cancer is the deadliest disease in the world behind heart disease. Sadly, this remains true even as we suffer the ravages of the Covid-19 pandemic. Whilst current chemo- and radiotherapeutic treatment strategies have significantly improved the patien
Autor:
Sajal Sen, Fumitaka Ishiwari, Ramandeep Kaur, Masatoshi Ishida, Debmalya Ray, Koichi Kikuchi, Takehiko Mori, Steffen Bähring, Vincent M. Lynch, Akinori Saeki, Dirk M. Guldi, Jonathan L. Sessler, Atanu Jana
Publikováno v:
Journal of the American Chemical Society.
We report here a nanosized "buckytrap"
Publikováno v:
Current Opinion in Chemical Biology. 73:102277
Autor:
Dan-Ying Huang, Hai-Hao Han, Axel Steinbrueck, Xiao-Peng He, Adam C. Sedgwick, Michael Y. Zhao, Sajal Sen, Jia Li, Yi Zang, Jonathan L. Sessler
Publikováno v:
Chem Commun (Camb)
We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 was found to have improved antiprol
Autor:
Jingqin Chen, Chengbo Liu, Tridib K. Sarma, Yaguang Ren, Qinchao Sun, Jonathan L. Sessler, Sajal Sen, Calvin V. Chau, Liang Song, Adam C. Sedgwick, Jonathan F. Arambula
Publikováno v:
Chemical Science
Photoacoustic imaging (PAI) relies on the use of contrast agents with high molar absorptivity in the NIR-I/NIR-II region. Expanded porphyrins, synthetic analogues of natural tetrapyrrolic pigments (e.g. heme and chlorophyll), constitute as potentiall
Autor:
Jonathan F. Arambula, Sajal Sen, Jonathan L. Sessler, Adam C. Sedgwick, Vincent M. Lynch, Mark W. Perrin
Publikováno v:
Chemical Science. 12:7547-7553
Recent decades have witnessed the emergence of Au(i) bis-N-heterocyclic carbenes (NHCs) as potential anticancer agents. However, these systems exhibit little interaction with serum proteins (e.g., human serum albumin), which presumably impacts their