Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sajal M. Patel"'
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1586-1594
Autor:
Mariam Ibrahim, Ian Wallace, Saba Ghazvini, Scott Manetz, Ruth Cordoba-Rodriguez, Sajal M. Patel
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1341-1344
Mechanism of Insoluble Aggregate Formation in a Reconstituted Solution of Spray-Dried Protein Powder
Autor:
Yeqing Tao, Yuan Chen, Wesley Howard, Mariam Ibrahim, Sajal M. Patel, William P. McMahon, Yoen Joo Kim, Jared A. Delmar, Darryl Davis
Publikováno v:
Pharmaceutical Research.
Background Spray-drying is considered a promising alternative drying method to lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted solutions of dried solid dosage forms of biologic drug products are closely monit
Autor:
Xiuling Lu, Rachel Kim, André O'Reilly Beringhs, William Zhang, Wei-Chung Luo, Sajal M. Patel, Robin H. Bogner
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 169:256-267
Freeze-drying is an effective approach to improve the long-term stability of nanomedicines. Lyoprotectants are generally considered as requisite excipients to ensure that the quality of nanoparticles is maintained throughout the freeze-drying process
Key factors governing the reconstitution time of high concentration lyophilized protein formulations
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 165:361-373
Lyophilized protein formulations containing highly concentrated proteins often have long and variable reconstitution times. Reconstitution time is dependent on a number of factors in a complex manner. Furthermore, factors influencing the reconstituti
Autor:
Wei-Chung Luo, William Zhang, Rachel Kim, Heather Chong, Sajal M. Patel, Robin H. Bogner, Xiuling Lu
Publikováno v:
International Journal of Pharmaceutics. :123084
Publikováno v:
Journal of Pharmaceutical Sciences. 109:2975-2985
Lyophilized protein formulations containing highly concentrated proteins often have long reconstitution times. The goal was to understand the role of formulation in mediating the reconstitution time. Formulation variables such as % total solids, prot
Autor:
Markela Ibo Murphy, Maria Bruque, Alexis Hanford, Isabelle Trayton, Melody Handali, Jesse A Leissa, Sathish Hasige, Katie Day, Sajal M Patel
Publikováno v:
Journal of pharmaceutical sciences. 111(6)
High-throughput analysis of low-volume samples for detection of subvisible particles (SVPs) in biologic formulations remains an unmet need in the pharmaceutical industry. Some commonly used methods, such as light obscuration and microflow imaging, fo
Publikováno v:
Molecular pharmaceutics. 18(8)
N-terminal glutamate can cyclize to form pyroglutamate (pGlu) in pharmaceutically relevant peptides and proteins. The reaction occurs nonenzymatically during storage for monoclonal antibodies and shows a strong 'pH' dependence in solution, but the so
Publikováno v:
International Journal of Pharmaceutics. 619:121694
While arginine hydrochloride (ArgHCl) has emerged as a potential stabilizer of protein drugs in liquid formulations, the purpose of this manuscript was to evaluate its stabilization potential in frozen solutions. The phase behavior of frozen ArgHCl s