How the VALID Act could affect patient access to laboratory developed testing for therapeutic drug monitoring

Autor: Saitman, Alec

Publikováno v: In Journal of Mass Spectrometry and Advances in the Clinical Lab April 2023 28:56-59

Evaluation and comparison of postmortem hydrocodone concentrations in peripheral blood, central blood and liver specimens: A minimal potential for redistribution

Autor: Saitman, Alec, Fitzgerald, Robert L., McIntyre, Iain M.

Publikováno v: In Forensic Science International February 2015 247:36-40

Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization.

Autor: Tolan NV; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Krasowski MD; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA., Mathias PC; Department of Laboratory Medicine and Pathology, Department of Biomedical Informatics and Medical Education, University of Washington School of Medicine, Seattle, WA, USA., Wiencek JR; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA., Babic N; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA., Chai PR; Harvard Medical School, Boston, MA, USA.; Department of Emergency Medicine, Division of Medical Toxicology, Brigham and Women's Hospital, Boston, MA, USA.; The Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Fenway Institute, Boston, MA, USA., Chambliss AB; Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA., Choucair I; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Demetriou CA; Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus, USA., Erickson TB; Harvard Medical School, Boston, MA, USA.; Department of Emergency Medicine, Division of Medical Toxicology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Humanitarian Initiative, Cambridge, MA, USA., Feldhammer M; Department of Pathology and Laboratory Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, FL, USA., French D; Department of Laboratory Medicine, University of San Francisco, San Francisco, CA, USA., Hayes BD; Harvard Medical School, Boston, MA, USA.; Department of Pharmacy, Massachusetts General Hospital, Boston, MA, USA., Kang P; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., El-Khoury JM; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Knezevic CE; Johns Hopkins University School of Medicine, Baltimore, MD, USA., Monte A; University of Colorado Anschutz, Aurora, CO, USA., Nerenz RD; Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.; Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Okorodudu AO; University of Texas Medical Branch, Galveston, TX, USA., Roper SM; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Saitman A; Providence Regional Laboratories, Portland, OR, USA., Thiriveedhi V; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Uljon SN; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Vest A; University of Colorado Anschutz, Aurora, CO, USA., Woodworth A; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA., Yu M; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA., Melanson SEF; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.

Publikováno v: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2023 Apr; Vol. 61 (4), pp. 248-259.

A 24-Hour Extended Calibration Strategy for Quantitating Tacrolimus Concentrations by Liquid Chromatography-Tandem Mass Spectrometry

Autor: Allister Brister-Smith, Jeffrey A Young, Alec Saitman

Publikováno v: The journal of applied laboratory medicine. 6(5)

Background Tacrolimus has a low therapeutic index requiring strict control of whole blood concentrations. Although random access immunoassay platforms exist that rapidly provide quantitative values for tacrolimus, LC–MS/MS may provide more accurate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e80569b340ee616018fb30d9354c9e
https://pubmed.ncbi.nlm.nih.gov/34136903

The Missing Metabolite: How Unexpected Urine Drug Metabolite Patterns May Lead to False Interpretations

Autor: Jeffrey A Young, Breland Elise Smith, Alicia Hutcherson Wright, Alec Saitman

Publikováno v: Clinical Chemistry. 64:1291-1293

A 31-year-old pregnant woman at 25-week gestation was admitted for preterm premature rupture of membranes and subsequently delivered preterm at 29 weeks. The patient insisted that she was unaware of the pregnancy and, thus, received no prenatal care.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626304c8af33755551237e431bdeff91
https://doi.org/10.1373/clinchem.2017.283507