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Akademický článek
Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization.
Autor: Grant Eilers, Kushol Gupta, Audrey Allen, Saira Montermoso, Hemma Murali, Robert Sharp, Young Hwang, Frederic D Bushman, Gregory Van Duyne
Publikováno v: PLoS Pathogens, Vol 19, Iss 3, p e1011097 (2023)
HIV integrase (IN) inserts viral DNA into the host genome and is the target of the strand transfer inhibitors (STIs), a class of small molecules currently in clinical use. Another potent class of antivirals is the allosteric inhibitors of integrase,
Externí odkaz: https://doaj.org/article/28bca840f72647ef9ea07ae7c3a99bd6
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2
Structure of a HIV-1 IN-Allosteric Inhibitor Complex at 2.93 Å Resolution: Routes to Inhibitor Optimization
Autor: Grant Eilers, Kushol Gupta, Audrey Allen, Saira Montermoso, Hemma Murali, Robert Sharp, Young Hwang, Frederic D. Bushman, Gregory Van Duyne
HIV integrase (IN) inserts viral DNA into the host genome and is the target of the strand transfer inhibitors (STIs), a class of small molecules currently in clinical use. Another potent class of antivirals is the allosteric inhibitors of integrase,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cd48c3599fbb2d7951d2930317e9dc
https://doi.org/10.1101/2022.06.09.495524
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Plný text Recenzováno Digitální knihovna AV ČR
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